Clinical trials: Cerebrovascular Apoplexy
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stroke
Effects of Home-based Program in Improving Sitting Balance and Upper Limb Functions in Patients With Stroke
The investigators hypothesize that application of electrical stimulation would augment the effects of exercises in patients with stroke.
- Trial name
- NCT01200030
- Testing
- electrical stimulation with exercises
- Where
- Hong Kong
- Volunteers
- 37 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke, Incentives
Stroke Patients' Outpatient Rehabilitation Therapy (SPORT)
Background: Stroke is the leading cause of long-term disability in Singapore, and studies have found that intensive specialized stroke rehabilitation can improve post-stroke functional outcomes for a substantial proportion of…
- Conditions
- Stroke, Incentives, Stroke Rehabilitation
- Trial name
- SPORT (NCT03165630)
- Testing
- Transportation incentives, Transportation and rehabilitation services incentives
- Where
- Singapore
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Atherosclerosis, Ischemic Stroke
A Phase I Study to Evaluate Safety and Pharmacokinetics of Escalating Single Doses and Multiple Doses of SP-8356
This is a 2-part, single-centre, randomised study in healthy males. Part 1 is a double-blind, randomised, placebo-controlled, single ascending dose (SAD) study in healthy males.
- Trial name
- NCT05574166
- Testing
- SP-8356
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Neurological Disease
Development, Reliability and Validity of the Telerehabilitation Usability Questionnaire- TrUQ
Neurological diseases are central nervous system diseases that cause an increase in the level of disability and limitations in daily life.
- Trial name
- NCT05970939
- Testing
- Development of the Telerehabilitation Usability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Gazi University
Stroke
Evaluate the Effectiveness and Safety of At-Home Rehabilitation Gait Training Using a Hip-assisted Wearable Robot in Stroke Patients
The goal of this clinical trial is to learn whether a wearable monitoring system can help adults who have had a stroke get more out of a home exercise program.
- Trial name
- NCT07716475
- Testing
- hip-assisted wearable robot
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Yonsei University
Stroke, Chronic Stroke
Reflex Excitability in Post-stroke Stiff-Knee Gait
The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait.
- Conditions
- Stroke, Chronic Stroke, Gait, Hemiplegic, Gait, Spastic
- Trial name
- NCT04947865
- Testing
- Peripheral nerve stimulation, Commercial knee brace
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Unilateral Spatial Neglect, Stroke
Comparing Prism Adaptation Training With and Without TENS to Minimize Unilateral Spatial Neglect
This study aims to find out if doing two treatments together-Prism Adaptation Therapy (PAT) and Transcutaneous Electrical Nerve Stimulation (TENS)-will help people who have had a stroke pay better attention to one side of their…
- Trial name
- NCT07157865
- Testing
- Prism adaptation training combined with TENS, PAT only
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Kettering Health Network
Stroke
This Study Evaluates the Use of a Data-driven Lower Limb Exoskeleton Controller for Stroke Rehabilitation.
The goal of this clinical trial is to test a new, impairment-aware robotic control software framework to see if its smart adaptation can improve walking recovery in healthy adults and chronic stroke survivors. .
- Trial name
- NCT07616167
- Testing
- Unified Control Framework for Lower-Limb Powered Orthosis, Conventional Robotic Controller
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stroke, Inpatients
A Novel Approach to Enhance True Recovery After Stroke
The purpose of this study is to elucidate pathophysiological mechanisms behind gait disturbances during the early recovery phase after hemiparetic stroke to identify targets for new treatment strategies.
- Conditions
- Stroke, Inpatients, Recovery of Function, Observational Study
- Trial name
- NCT05359367
- Testing
- Observational
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Danderyd Hospital
Stroke, Spinal Cord Injuries and Disorders
Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis
This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke.
- Conditions
- Stroke, Spinal Cord Injuries and Disorders, Hemiparesis After Stroke
- Trial name
- NCT07153536
- Testing
- Spinal Cord Stimulator (Medtronic Inceptiv™ System), Physical Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Marco Capogrosso
Stroke
Sour Taste and Cold Temperature in Dysphagia
The objective is to establish the effect of sour taste and cold temperature on the pharyngeal swallowing transit time after ischemic hemisphere stroke.
- Trial name
- NCT00780364
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Stroke, Acute
Telerehabilitation-Based Early Upper Extremity Training in Stroke Patients
Telerehabilitation method, which is an alternative to face-to-face rehabilitation practices for stroke patients who need intensive, regular and long-term rehabilitation in the early period, has been popularly used in recent…
- Trial name
- NCT06261099
- Testing
- control + working group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Suleyman Demirel University
Ischemic Stroke
Clopidogrel Response in Acute Ischemic Stroke
The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.
- Trial name
- Bo-CRISP (NCT01846572)
- Volunteers
- 159 people
- Sponsor
- Ruhr University of Bochum
Stroke, Gait, Hemiplegic
Effects of an Ankle-Foot Orthosis on Gait While Performing an Attention Demanding Task
We hypothesize that: (1) gait stability will be increased when wearing an ankle-foot orthosis (plastic brace supporting the foot and ankle); (2) an attention demanding task will decrease gait stability and (3) the improvement in…
- Trial name
- NCT01320839
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Nova Scotia Health Authority
Carotid Artery Stenosis, Strokes
Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes
The investigators hypothesize that pre-operative statin use is neuroprotective at maximal doses. The goals are to determine the safety, feasibility, and efficacy of maximizing statin doses for two weeks (12-18 days) prior to CEA…
- Trial name
- STANCE (NCT02850081)
- Testing
- Statin, Atorvastatin
- Where
- 7 sites in United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Spasticity, Muscle, Stroke
Multimodal Instrumented Assessment of Post-stroke Elbow
The proposed clinical trial will employ the NEUROExos Elbow Module (NEEM), an active robotic exoskeleton, for the passive mobilization and active training of elbow flexion and extension in 60 sub-acute and chronic stroke patients…
- Conditions
- Spasticity, Muscle, Stroke, Upper Limb
- Trial name
- NCT04484571
- Testing
- Neuroexsos elbow module
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda USL Toscana Nord Ovest
Stroke, Motor İmagery Ability
Investigation Of The Relationship Between Imagery Ability, Balance And Functionality After Stroke
It was aimed to determine the relationship between post-stroke imagination ability, balance, and functionality, and to compare the motor imagery skills of those who had stroke with compatible healthy individuals.
- Conditions
- Stroke, Motor İmagery Ability, Mental Chronometry, Balance
- Trial name
- NCT04832334
- Testing
- Kinesthetic and Visual Imagery Questionnaire, Box and Block Test, Hand Lateralization Test., Berg Balance Scale, Functional Reach Test, Timed Up and Go Test, Functional Independence Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medipol University
Stroke
Music Listening for Cardiorespiratory Exercise in Inpatient Stroke Rehabilitation
Stroke survivors struggle to meet clinical recommendations for physical exercise duration and intensity. During the past two decades, music interventions have increasingly shown effectiveness in several motor tasks in stroke…
- Trial name
- NCT05398575
- Testing
- Music
- Where
- Denmark
- Volunteers
- 19 people
- Sponsor
- University of Aarhus
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