Clinical trials: Cerebrovascular Apoplexy
Stroke, Depression
Post-Stroke Optimization of Walking Using Explosive Resistance
The investigators will study the effects of a 12 week strength training program on individuals who have had a stroke and are depressed to see if this type of exercise training helps treat depression and improves walking function.
- Trial name
- POWER-D (NCT03826771)
- Testing
- Power training, Stretching
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Cerebral Stroke, Traumatic Brain Injury
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
- Conditions
- Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
- Trial name
- NCT06069999
- Testing
- HandyMotion Treatment Program
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- TRCare, Inc.
Periodontal Disease, Stroke
PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic…
- Conditions
- Periodontal Disease, Stroke, TIA
- Trial name
- PREMIERS (NCT02541032)
- Testing
- Intensive dental treatment, Standard dental treatment, Arestin
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of South Carolina
Acute Ischemic Stroke
Efficacy and Safety of Indobufen, Aspirin, Cilostazol and Clopidogrel in the Treatment of Ischemic Stroke
Through a single-center retrospective cohort study of acute ischemic stroke (AIS) patients receiving secondary prevention with indobufen, clopidogrel, cilostazol, or aspirin as monotherapy or dual therapy, we aim to compare the…
- Trial name
- NCT07604298
- Testing
- indubufen, aspirin, clopidogrel, cilostazol
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ischemic Stroke
Combined taVNS and tDCS in Subacute Stroke Patients
Ischemic stroke, the most prevalent neurological disorder, is treated with medication and thrombectomy but with limited success, especially in chronic stages where traditional rehabilitation is the primary option.
- Trial name
- NCT06244914
- Testing
- tDCS stimulation, taVNS stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Stroke Hemorrhagic, Intracerebral Haemorrhage
Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
This study aims to explore the effectiveness of tranexamic acid (also known as trans amine or TXA) in reducing hematoma expansion in patients with hemorrhagic stroke when given in the acute phase.
- Trial name
- TRANSACT (NCT03044184)
- Testing
- Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 220 people
- Sponsor
- Kwong Wah Hospital
Stroke, Cerebrovascular Disorders
Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
The purpose of this study is to investigate whether aerobic exercise improves the participant's ability to recover function in the arm and leg affected by the participant's stroke.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT03819764
- Testing
- Aerobic Exercise, Upper Extremity Repetitive Task Practice
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Stroke, Endovascular Repair
GA vs. CS for Endovascular Stroke Therapy
After a stroke caused by a blockage (clot) in a blood vessel in the brain, patients may have the clot removed by threading a catheter from the groin up to the affected area of the brain.
- Conditions
- Stroke, Endovascular Repair, Anesthesia
- Trial name
- NCT03247998
- Testing
- General Anesthesia, Conscious Sedation with Remifentanil
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke
Exercise and Brain Stimulation for Post-stroke Depression
This project will assess the effects of aerobic exercise training (AET), repetitive transcranial magnetic stimulation (rTMS) or their combination on depressive severity as well as locomotor function in persons with post-stroke…
- Trial name
- NCT03056287
- Testing
- Aerobic exercise, Repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medical University of South Carolina
Stroke
The Effect of Ankle Foot Orthesis on Task-oriented Treatment in Stroke
A stroke is a neurological condition and a major cause of disability in adults. It occurs suddenly and causes specific brain function problems, leading to noticeable symptoms that last for more than 24 hours.Stroke commonly…
- Trial name
- NCT06840132
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ankara Medipol University
Stroke
Exploring Cerebellar Inhibition of the Motor Cortex in Stroke Patients
The past 10 years of research in post stroke patients have shown certain types of rehabilitation can help neuronal plasticity of the brain.
- Trial name
- NCT02401698
- Testing
- Functional clinical and TMS diagnostic
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke, Post-stroke Cognitive Impairment (PSCI)
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
Post-stroke cognitive impairment (PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for at least 24 weeks.
- Trial name
- Be-CLEVER (NCT05976152)
- Testing
- dl-3-butylphthalide
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- Fudan University
Carotid Stenosis, Carotid Artery Diseases
Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
About 20% of strokes are caused by emboli deriving from a carotid plaque. In symptomatic patients with carotid stenosis grater than 70% the Carotid Endarterectomy (CEA) reduces stroke risk by about 75% and is generally accepted…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT05134493
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Stroke, Hemiparesis
EEG Brain-Machine Interface Control of an Upper-Limb Robotic Exoskeleton for Robot-Assisted Rehabilitation After Stroke
The goal of this study is to develop a clinically feasible, low-cost, nonsurgical neurorobotic system for restoring function to motor-impaired stroke survivors that can be used at the clinic or at home.
- Trial name
- NeuroExo (NCT05374486)
- Testing
- NeuroExo co-robot neurorehabilitation system
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Houston
Stroke, Spastic Hemiplegia
Effects of Neuromuscular Electrical Stimulation on Flexor Spasticity and Function in Stroke Patients
In this study, the investigators aimed to determine the effects of botulinum neurotoxin type A injections for wrist and finger flexor spasticity and neuromuscular electrical stimulation therapy applied to wrist and finger flexors…
- Trial name
- NCT06725069
- Testing
- Neuromuscular Electrical Stimulation, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Acute Stroke, Dysphagia
Transesophageal Echocardiography: Dysphagia Risk in Acute Stroke (T.E.D.R.A.S. Trial)
The prevalence of dysphagia in acute stroke patients undergoing transesophageal echocardiography (TEE) is unknown. The aim of this study was to assess for the first time whether TEE has a negative influence on swallowing in acute…
- Conditions
- Acute Stroke, Dysphagia, Swallowing Disorder
- Trial name
- TEDRAS (NCT04302883)
- Testing
- Transesophageal Echocardiography (TEE), Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University of Giessen
Acute Stroke
Cytoflavin in Combination With Reperfusion in Stroke Patients
Evaluation of the efficacy and safety of Cytoflavin®, solution for intravenous administration, (OOO NTFF POLYSAN, Russia) for 10 days, patients with cerebral infarction who receive reperfusion therapy, with the start of treatment…
- Trial name
- NCT05297851
- Testing
- Cytoflavin (succinic acid + inosine + nicotinamide + riboflavin), Control
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Atrial Fibrillation, Stroke
Aspirin Discontinuation After Left Atrial Appendage Occlusion in Atrial Fibrillation
The ASPIRIN LAAO trial is a prospective, multi-center, randomized, double blinded, placebo-controlled study aiming at investigating the safety of terminating the use of aspirin after left atrial appendage occlusion (LAAO).
- Conditions
- Atrial Fibrillation, Stroke, Bleeding
- Trial name
- ASPIRIN-LAAO (NCT03821883)
- Testing
- Aspirin Tablet
- Where
- China
- Volunteers
- 1,120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅰ (NCT06901466)
- Testing
- Experimental: Rivaroxaban monotherapy, Active Comparator: Rivaroxaban+Clopidogrel
- Where
- China
- Volunteers
- 880 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Stroke
Effects of Intensive Virtual Reality-Based Balance and Gait Training on Activity Performance and Quality of Life in Subacute Stroke Patients
Stroke is one of the leading causes of long-term disability worldwide, and balance and gait impairments are common in the subacute phase, limiting activity performance and quality of life.
- Trial name
- NCT07431151
- Testing
- Virtual Reality-Based Balance and Gait Training, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ankara Yildirim Beyazıt University
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