Clinical trials: Cerebrovascular Disease
Sedation of Cerebrovascular Ventilated Critical Care Patients
Sedation Depth in Neurocritical Care
Background: Sedation of the intensive care unit (ICU) patient is necessary to relieve the patient from pain, anxiety and agitation and to enable mechanical ventilation, diagnostic investigations and invasive procedures.
- Trial name
- MODERNISE (NCT02317497)
- Testing
- Intensive Care Sedation (depth, level), Vasopressors to maintain normal blood pressure values, if needed, Osmotherapeutics to lowr intracranial pressure, if needed
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heidelberg University
Cardiovascular Diseases, Cerebrovascular Disorders
The ARIC MRI Study
To perform a follow-up study of cerebrovascular disease in the Atherosclerosis Risk in Communities (ARIC) magnetic resonance imaging subcohort.
- Conditions
- Cardiovascular Diseases, Cerebrovascular Disorders, Cerebrovascular Accident
- Trial name
- NCT00049920
- Volunteers
- 1,134 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asymptomatic Carotid Artery Stenosis
" Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke "
The purpose of this study is to determine whether carotid surgery combined with optimal medical therapy improves long-term survival free of ipsilateral stroke in patients with asymptomatic carotid stenosis at higher-than-average…
- Trial name
- ACTRIS (NCT02841098)
- Testing
- Carotid endarterectomy (CEA) combined with optimal medical therapy (OMT), Optimal medical therapy alone
- Where
- 23 sites in France
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier St Anne
Fabry Disease
A Safety and Efficacy Study of Fabrazyme® Replacement Therapy in Patients With Cardiac Fabry Disease
This is a multi-center, open label, phase IV study conducted to evaluate the efficacy and safety of agalsidase beta (Fabrazyme [recombinant form]) administered by intravenous drip infusion in participants with cardiac Fabry…
- Trial name
- NCT00140621
- Testing
- Agalsidase beta
- Where
- 7 sites in Japan
- Volunteers
- 6 people
- Sponsor
- Genzyme, a Sanofi Company
Ischemic Stroke
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
EXCELLENT was a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study in which participants were randomized participants were randomized (1:1) to receive either IV thrombolysis + edaravone or IV…
- Trial name
- EXCELLENT (NCT07119021)
- Testing
- Intravenous thrombolysis + edaravone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijun Ji
Chronic Subdural Hematoma
General Anesthesia Versus Locoregional Anesthesia for Evacuation of Chronic Subdural Hematoma
This study compare general anesthesia versus locoregional anesthesia for evacuation of chronic subdural hematoma. Half of participant will be operated under general anesthesia, while the other half will be operated under…
- Trial name
- NCT03666949
- Testing
- All General anesthesia, All Locoregional anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Stroke
The Effectiveness of High-intensity Laser Therapy on Plantar Flexor Muscle Spasticity in Stroke Patients
The aim of this study is to investigate the effectiveness of high-intensity laser therapy for treating plantar flexor muscle spasticity in subacute and chronic stroke patients, focusing on its impact on spasticity, joint range of…
- Trial name
- NCT06357949
- Testing
- High-intensity laser
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Ischemic Stroke
Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients
Personalized therapy as prophylaxis in ischemic stroke patients is not yet an option. From patients with ischemic heart disease, we know that patients with in vitro high on treatment platelet reactivity (HTPR) have an increased…
- Trial name
- CLOGIS (NCT03385538)
- Testing
- Clopidogrel
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Zealand University Hospital
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
Stroke, Stroke Assessment
Artificial Intelligence-Assisted Magnetic Resonance Imaging Diagnostic Strategy in a Tertiary Stroke Center
Quality improvement study with prospective observational design. The study monitors the diagnostic accuracy of an AI-assisted resident radiologist-termed the AI-ResRad diagnostic strategy-compared to an on-call specialist…
- Trial name
- AID-STROKE (NCT07390708)
- Testing
- Index test (AI-ResRad), Reference test (SpecNeuroRad), Comparative Index tests: ResRad and AI-SpecNeuroRad
- Where
- 2 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Aarhus University Hospital
Stroke
Transcranial Direct Current Stimulation and Cognitive Behavioural Programme on Post-stroke Fatigue
This study aims to evaluate the effect of transcranial direct current stimulation and cognitive behavioural programme on fatigue and its related outcomes among people with stroke.
- Trial name
- NCT06810817
- Testing
- tDCS & cognitive behavioral programme with home-based physical training, physical training
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- The Hong Kong Polytechnic University
Cardiovascular Disease
The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and…
- Trial name
- SPIRE-1 (NCT01975376)
- Testing
- bococizumab (PF-04950615)
- Where
- 1,745 sites in United States, Argentina and 34 more
- Volunteers
- 16,784 people
- Sponsor
- Pfizer
Stroke
Clinical Charactaristics , Risk Factors and Outcomes of Stroke in Pediatric Patients at Assiut University Children's Hospital
Summary of the study is to recognize clinical picture , to identify risk factors and evaluate outcomes of stroke in pediatric patients
- Trial name
- NCT07120568
- Volunteers
- 45 people
- Sponsor
- Assiut University
Ischemic Stroke
"Hemodynamic Changes During Endovascular Revascularization for Acute Stroke. An Observational Study".
Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, i.e. the effects of cardiac injury on the brain, and the effects of brain injury on the heart.
- Trial name
- NCT04771468
- Testing
- MOSTCAREup Monitoring, Ecocardiography
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Intracranial Aneurysms, Cavernous Carotid Fistula
Neurovascular Embolization Cover for Treatment of Intracranial Aneurysms and Carotid/Vertebrobasilar Fistulae
The purpose of this study is to determine whether the NEC device can effectively occlude the intracranial aneurysm or the carotid/vertebrobasilar fistula and maintain parent vessel patency
- Conditions
- Intracranial Aneurysms, Cavernous Carotid Fistula, Vertebrobasilar Fistula
- Trial name
- NCT01054391
- Testing
- NEC - Neurovascular Embolization Cover
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- Nfocus Neuromedical
Motor Disorders, Gait Disorders, Neurologic
Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population
In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990.
- Conditions
- Motor Disorders, Gait Disorders, Neurologic, Neurodegenerative Diseases, Spinal Cord Injuries
- Trial name
- ALERT (NCT06538974)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Wandercraft
Stroke, Hemiplegia
Treatment Protocol for Hemiplegic Shoulder Pain
The purpose of this study is to determine if a specific stretching and strengthening protocol, in addition to current standard treatment, is more effective for treating post-stroke shoulder pain than current standard treatment…
- Conditions
- Stroke, Hemiplegia, Shoulder Pain
- Trial name
- TPHSP (NCT01232218)
- Testing
- Standard education/exercises for hemiplegic shoulder pain, Three dimensional Scapular-Humeral Mobilizations
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Toronto Rehabilitation Institute
Moyamoya Disease, Moyamoya Syndrome
Chinese Herbal Therapy (Qiqi Shengmai Formula) for Moyamoya Vasculopathy: The CHIMES Trial
Patients diagnosed with moyamoya vasculopathy by imaging and classified as having the Traditional Chinese Medicine (TCM) syndrome of liver-yang hyperactivity will be enrolled.
- Trial name
- NCT07286110
- Testing
- Traditional Chinese Medicine (TCM) Treatment, Conventional medical treatment
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fudan University
Coronary Artery Disease
the Change of CEM and the Prognosis of Coronary Artery Disease in Real Clinical Practice
The purpose of this study is to investigate the change of total cholesterol content of erythrocyte membranes (CEM) in patients with coronary artery disease treated with secondary prevention drugs, and the correlation with the…
- Trial name
- CCEMPCAD (NCT03473860)
- Volunteers
- 200 people
- Sponsor
- Lu'an Municipal Hospital
Stroke, Stroke, Acute
BURT Efficacy in Improving Upper Extremity Strength and Function During Post-stroke Inpatient Rehabilitation
The Barrett Upper Extremity Robot (BURT) is an FDA-approved upper extremity robot that assists patients with both passive and active range of motion while providing adjustable resistance (Barrett_Medical.
- Conditions
- Stroke, Stroke, Acute, Cerebral Vascular Accident, Cerebral Vascular Accident (CVA)/Stroke
- Trial name
- NCT05401799
- Testing
- BURT, Other Occupational Therapy
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Sunnyview Rehabilitation Hospital
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