Clinical trials: Cerebrovascular Disease
Hypoxic Ischaemic Encephalopathy
Correlation of Risk Factors and Severity of Hypoxic-ischaemic Encephalopathy
The first aim of this study is to analyse perinatal risk factors leading to hypoxic ischaemic encephalopathy in term and near term neonates born in Switzerland who were admitted to the neonatal and intensive care units offering…
- Trial name
- NCT02800018
- Testing
- risk factors
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Children's Hospital, Zurich
Stroke
1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients
The objective of the study is to find out the 1-year clinical outcomes among Acute Ischaemic Stroke (AIS) patients who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5 hours of…
- Trial name
- NCT05395338
- Testing
- rt-PA
- Where
- China
- Volunteers
- 12,551 people
- Sponsor
- Boehringer Ingelheim
Intracranial Atherosclerosis
Post Market Surveillance Study of the Wingspan Stent System
The primary objective of this study is to evaluate the rate of stroke and/or death in patients treated with the Wingspan Stent System, according to the Indications for Use, within 72 hours post procedure.
- Trial name
- WEAVE (NCT02034058)
- Testing
- Wingspan Stent System
- Where
- 26 sites in United States
- Volunteers
- 152 people
- Sponsor
- Stryker Neurovascular
Acute Ischemic Stroke
BALANCE Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
Elevated blood pressure (BP) is nearly universal in acute ischemic stroke (AIS) and critically influences eligibility for intravenous thrombolysis; however, current guidelines-requiring BP reduction to below 185/110 mmHg before…
- Trial name
- NCT07318948
- Testing
- Concurrent Thrombolysis
- Where
- 2 sites in China
- Volunteers
- 1,600 people
- Sponsor
- Bo Wu
Stroke, Hemiparesis
Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors
The goal of this study is to: 1. Assess the usability of the SynPhNe device in a home environment. 2. Evaluate the efficacy of the SynPhNe home use device to improve motor hand function in chronic stroke subjects as compared to…
- Trial name
- NCT02896348
- Testing
- SynPhNe platform, Conventional therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Spaulding Rehabilitation Hospital
Ischemic Stroke, Transient Ischemic Attack
Trial of a Secondary Stroke Prevention Program
The purpose of this study is to determine whether an outpatient program can reduce the risk of recurrent stroke.
- Trial name
- NCT01071408
- Testing
- Stroke prevention care program
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Sepulveda Research Corporation
Spasticity as Sequela of Stroke, Stroke
Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke
The purpose of this study is to investigate if two courses of five consecutive sessions of noninvasive spinal stimulation paired with peripheral nerve stimulation at the forearm provided by an investigational device (Doublestim™/…
- Conditions
- Spasticity as Sequela of Stroke, Stroke, Stroke Sequelae, Hemiplegia, Spastic
- Trial name
- NCT04113525
- Testing
- MyoRegulator™ System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwell Health
Stroke
Coughing in Infratentorial Brain Lesion Patients
To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university…
- Trial name
- NCT02081040
- Testing
- Not applicable (observational study with no active intervention)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- The Catholic University of Korea
Cerebral Palsy, Intraventricular Hemorrhage
Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%.
- Conditions
- Cerebral Palsy, Intraventricular Hemorrhage, Periventricular Leukomalacia, Pulmonary Edema
- Trial name
- BEAM (NCT00014989)
- Testing
- magnesium sulfate
- Where
- 17 sites in United States
- Volunteers
- 2,136 people
- Sponsor
- The George Washington University Biostatistics Center
Intracerebral Hemorrhage
Efficacy and Safety of Factor VIIa on Rebleeding After Surgery for Spontaneous Intracerebral Hemorrhage (ICH)
Although the role of surgical treatment is still controversial, surgical evacuation of intracerebral hematoma is a frequent practice. Rebleeding is a frequent complication in patients submitted to hematoma evacuation.
- Trial name
- PRE-SICH (NCT00128050)
- Testing
- rFactor VIIa (Eptacog alfa, NovoNordisk), rFVIIa, Sodiun chloride 0.9%
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Dementia, Vascular
A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia
This is a trial to evaluate the safety and effectiveness of galantamine in patients with dementia secondary to blood vessel disease in the brain.
- Trial name
- NCT00035191
- Testing
- galantamine
- Volunteers
- 254 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Stroke, Inflammation
PET/MR in Post Stroke Cardiac Inflammation Study
Patients with stroke have a 25x higher risk of cardiovascular complications within the first 30 days of the event compared to individuals without stroke. The mechanisms behind these complications are not well understood.
- Trial name
- PEPSI (NCT05791617)
- Testing
- cardiac PET/MRI, Inflammatory markers, Diagnostic Test: NT-proBNP
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Luciano A. Sposato
Ischemic Stroke
"Hemodynamic Changes During Endovascular Revascularization for Acute Stroke. An Observational Study".
Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, i.e. the effects of cardiac injury on the brain, and the effects of brain injury on the heart.
- Trial name
- NCT04771468
- Testing
- MOSTCAREup Monitoring, Ecocardiography
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Embolic Stroke, Postoperative Cognitive Dysfunction
Perfusion Pressure Cerebral Infarction Trial (PPCI)
STUDY HYPOTHESIS In cardiac surgery the volume of perioperative cerebral infarctions can be reduced by increasing mean arterial pressure (MAP) during the cardiopulmonary bypass procedure.
- Trial name
- PPCI (NCT02185885)
- Testing
- Increased bloodpressure during CPB.
- Where
- Denmark
- Volunteers
- 197 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Basal Ganglia Hemorrhage
Minimally Invasive Treatment of Hypertensive Basal Ganglia Hemorrhage by Transfrontal Keyhole Neuroendoscopy
To compare the prognosis of patients with hypertensive intracerebral hemorrhage treated by two different surgical methods, and to clarify the therapeutic effect of minimally invasive surgery, so as to find a better surgical…
- Trial name
- NCT04958525
- Testing
- Keyhole neuroendoscopic transfrontal ultrasound-guided hematoma removal, Small bone window craniotomy for hematoma removal under microscope
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Intracerebral Hemorrhage, Acute Ischemic Stroke
Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
This study aims to determine whether in-bed cycle ergometry, early in the hospital course after a brain hemorrhage could balance damaging and reparative inflammation in the brain.
- Trial name
- BEACH (NCT04027049)
- Testing
- Supine cycle ergometry of the lower extremities
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Stroke
The Evaluation of Safety, Tolerability and Pharmacokinetics of Stroke Targeting Drug in Healthy Volunteers
The purpose of this study in to evaluate safety, tolerability, pharmacokinetics of JPI-289 in healthy male subjects.
- Trial name
- JPI-289 (NCT01983358)
- Testing
- JPI-289
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Ischemic Stroke
Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS)
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive…
- Trial name
- BAMUS-ICAS (NCT06763458)
- Testing
- Submaximal balloon angioplasty
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke, Dysphagia
Effects of ITBS Combined with NMES on Dysphagia After Stroke
In recent years, research on intermittent Theta Burst Stimulation (iTBS), as a special high-frequency （repetitive transcranial magnetic stimulation，rTMS） stimulation paradigm, has focused on exploring the effects in healthy…
- Conditions
- Stroke, Dysphagia, Intermittent Theta Burst Stimulation, Neuromuscular Electrical Stimulation
- Trial name
- NCT06464835
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 45 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Stroke
Causal Evidence for Task Regulation by Anterior Cingulate Cortex
The exact function of the anterior cingulate cortex (ACC) is one of the largest riddles in cognitive neuroscience and a major challenge in mental health research.
- Trial name
- NCT04650425
- Testing
- Cognitive tasks
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
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