Clinical trials: Cerebrovascular Disease
Spasticity as Sequela of Stroke
Observational Longitudinal Study on the Outbreak and Management of Stroke Related Spasticity
Stroke is one of the leading cause of death and disability worldwide. Post-stroke spasticity (PSS) is outbreak after a stroke and is featured by disabling muscle stiffness.
- Trial name
- COLOSSEO (NCT05379413)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Italy
- Volunteers
- 960 people
- Sponsor
- Campus Bio-Medico University
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Symptomatic Chronic Middle Cerebral Artery Occlusion, Infarction, Middle Cerebral Artery
Extracranial-intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion: the CMOSS-2 Trial
The CMOSS-2 trial is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit symptomatic chronic occlusion of the middle cerebral artery in patients with severe hemodynamic insufficiency.
- Trial name
- NCT05899582
- Testing
- Extracranial-Intracranial Bypass Surgery, Medical treatment alone
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Xuanwu Hospital, Beijing
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Safety of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke
This study will determine if NXY-059 is safe in patients with an acute stroke caused by bleeding in the central nervous system. The primary objective was to assess the safety and tolerability of NXY-059 compared to placebo.
- Trial name
- NCT00075959
- Testing
- NXY-059
- Where
- 64 sites in United States
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Mitochondrial Diseases, Mitochondrial Myopathies
Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).
The goal of this study is to find the best way to help people with primary mitochondrial disease deal with the stress of their condition, and to help these people be better able to "bounce back," or be resilient.
- Conditions
- Mitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Encephalomyopathies, MELAS
- Trial name
- NCT06051448
- Testing
- Promoting Resilience in Stress Management (PRISM), Clinical-focused narrative (CFN)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Ischemic Stroke, Hemorrhagic Stroke
A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1)
Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease.
- Trial name
- iCOOL 1 (NCT01573117)
- Testing
- RhinoChill, Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Intracranial Aneurysms
Evaluation of a Novel Intrasaccular Embolization Device for the Treatment of Intracranial Aneurysms
The study is a prospective, multicenter single-arm cohort. The purpose of this study is to evaluate efficacy and safety of a novel intrasaccular embolization device for the treatment of intracranial aneurysms.
- Trial name
- NCT07022249
- Testing
- Intrasaccular Embolization Device
- Volunteers
- 150 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Cerebral Vascular Accident (CVA)
Predictive Value of Copeptin in the Diagnosis of Acute Ischemic Stroke
In the USA, every year 795,000 patients suffer a cerebral vascular accident (CVA), which represents a yearly cost of $73.7 billion.
- Trial name
- NCT01960478
- Testing
- (for each intervention), Blood test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke, TIA
Diabetes in Minor Stroke/TIA, Glucose Tolerance and Haemostasis, a Long-term-follow-up Study and Intervention With Yoga
In acute stroke patients about 20 % have known diabetes. There is a doubled risk of recurrent stroke in diabetic patients. It has been shown that antiplatelet drugs are not as effective in diabetic patients as in non-diabetic…
- Trial name
- NCT01648985
- Testing
- Diabetes in stroke/TIA
- Where
- Sweden
- Volunteers
- 144 people
- Sponsor
- Karolinska Institutet
Healthy Volunteers
An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants
The purpose of this study is to investigate the effect of taking multiple doses of BMS-986177 when aspirin is taken once-daily. Eligible participants will receive twice-daily doses of BMS-986177 or placebo, with a once-daily dose…
- Trial name
- NCT03341390
- Testing
- Aspirin, BMS-986177
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Ischemic Stroke, Stroke Rehabilitaion
Neurological Rehabilitation and Neuroplasticity After Ischemic Stroke
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke.
- Trial name
- NCT07899710
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Stroke
Feasibility Study and Pilot RCT Into the Use of a Novel Technology to Train Sitting Balance and Trunk Control
Additional trunk therapy is proven to be effective for improving trunk function and sitting balance. However, conventional trunk therapy is limited by the needed supervision of a therapist and when using unstable surfaces, only a…
- Trial name
- NCT04440748
- Testing
- T-Chair 2.0 Prototype, General Rehabilitation Programme
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Jan Kool
Ischemic Stroke
Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
The current study aims to evaluate the safety of SP-8203, designing in two stages (stage-1, stage-2) to evaluate the safety and efficacy of the combination therapy of SP-8203 and rtPA for the occurrence of cerebral hemorrhage in…
- Trial name
- SP-8203-2001 (NCT02787278)
- Testing
- SP-8203 High dose, SP-8203 Low dose
- Where
- 8 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Craniopharyngioma, Apoplexy
Craniopharyngioma With Tumoral Hemorrhage
Clinical data of 185 consecutive patients receiving resective operation with a pathological diagnosis of craniopharyngioma in our hospital between January 2013 and February 2021 were collected.
- Trial name
- NCT04937335
- Testing
- intratumoral hemorrhage
- Volunteers
- 185 people
- Sponsor
- Tongji Hospital
Ischemic Stroke, Intracerebral Haemorrhage
Head Position in Stroke Trial (HeadPoST)
This study is an investigator-initiated and conducted, international collaborative, regionally organised, multicentre, prospective, cluster randomised, crossover, blinded outcome assessment study to compare the effectiveness of…
- Trial name
- HeadPoST (NCT02162017)
- Testing
- The lying flat (0°) head position for 24 hours, The sitting-up (≥30°) head position for 24 hours
- Where
- Australia
- Volunteers
- 11,096 people
- Sponsor
- The George Institute
Mobile Applications, Secondary Prevention
The Use of Samsung Health and ECG M-Trace Base II Applications in the Secondary Prevention After Stroke
The aim of the present study was to quantitatively assess the risk factors that may affect the re-occurrence of a CVD event and the use of a commercially available mobile application Samsung Health for the assessment of…
- Conditions
- Mobile Applications, Secondary Prevention, Stroke
- Trial name
- NCT04821518
- Where
- Poland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Stroke, Post Stroke Fatigue
Treatment of Post Stroke Fatigue With a Wakefulness Promoting Agent
This study is an investigator initiated placebo controlled double blinded trial. The hypothesis is that treatment with modafinil positively will affect behavioural and cognitive rehabilitation after stroke, causing the treatment…
- Trial name
- NCT01800097
- Testing
- modafinil
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Herlev Hospital
Ischemic Stroke
Functional Prognosis in Patients With Ischemic Stroke According to the Therapeutic Strategy Used
The current management of ischemic stroke is based on different strategies that may be combined: intravenous thrombolysis in a stroke ICU, intravenous thrombolysis in a telemedicine procedure, endovascular thrombectomy.
- Trial name
- PARADISE (NCT02856074)
- Testing
- prise de sang, quality of life questionnaire
- Where
- France
- Volunteers
- 821 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.