Clinical trials: Cerebrovascular Diseases
Ischemic Stroke
Efficacy of Colchicine in Preventing Recurrent Stroke in the Patients With Acute Atherothrombotic Ischemic Stroke During Hospitalization
This study is two-center, prospective, randomized, open-label, controlled, investigator-sponsored study that aims to investigate the efficacy of low-dose colchicine in preventing recurrent stroke in the patients with acute…
- Trial name
- COLCHIDA (NCT06102720)
- Testing
- Colchicine, Clopidogrel
- Where
- 2 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Mikhail Zykov
Ischemic Heart Disease, Ischemic Stroke
Study to Compare 2 Doses of Polycap Versus Single Dose of Polycap With or Without Pottasium
This is a randomized double blind 2x2 factorial controlled trial to evaluate efficacy tolerability of low strength Polycap versus two doses of low strength Polycap in patients with stable cardiovascular disease in reducing blood…
- Conditions
- Ischemic Heart Disease, Ischemic Stroke, Peripheral Vascular Disease, Type 2 Diabetes Mellitus
- Trial name
- TIPSK (NCT01404078)
- Testing
- Single Dose Polycap, Double dose Polycap
- Volunteers
- 518 people
- Sponsor
- St. John's Research Institute
Atrial Fibrillation, Stroke
Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate
The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram.
- Trial name
- LAATAS (NCT06405750)
- Testing
- left atrial appendage closure
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Intraventricular Hemorrhage, Periventricular Leukomalacia
Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
Intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) are brain lesions that commonly occur in preterm infants and are well-recognized major contributors to long-term brain injury and related disabilities later…
- Conditions
- Intraventricular Hemorrhage, Periventricular Leukomalacia, Brain Injury, Renal Injury
- Trial name
- NCT02221219
- Testing
- Indomethacin, delay in umbilical cord clamp at birth, immediate cord clamp at birth
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Hong Huang
Stroke, Upper Limb Paresis
Thermal Stimulation for Stroke Patients
Sensory and/or motor deficits in upper limb following stroke often have negative impacts on their daily living. Thermal stimulation with hot and cold pack alternatively incorporated into conventional rehabilitation has been…
- Trial name
- TSSP (NCT01658293)
- Testing
- thermal stimulation, control group ergometer exercises
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Hemorrhagic Stroke, Ischemic Stroke
Effects of Short-intensity Modified Constraint-induced Movement Therapy on Hand Function in Stroke Patients.
To determine effects of short-intensity modified constraint-induced movement therapy on hand function in stroke patients.
- Conditions
- Hemorrhagic Stroke, Ischemic Stroke, Rehabilitation
- Trial name
- NCT05916885
- Testing
- short-intensity modified CIMT and conventional therapy, conventional therapy alone
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Carotid Atherosclerosis
Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)
The purpose of the study is to determine if short term (6 months) treatment with statins to lower low-density lipoprotein (LDL) in vascular disease patients with carotid plaque will be associated with a measurable reduction in…
- Trial name
- NCT00388843
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Fabry's Disease
Analysis of the Nervous System in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme ceramidetrihexosidase. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Trial name
- NCT00001491
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aneurysm, Brain
Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and…
- Trial name
- PRAEMIUM (NCT04819074)
- Testing
- Microsurgery
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 4,000 people
- Sponsor
- University of Zurich
Stroke, Hemiparesis
Motor Imagery Added to Robot-Assisted Hand Rehabilitation After Stroke
Loss of upper extremity and particularly hand function after stroke reduces independence in daily activities such as eating, dressing, and personal care.
- Conditions
- Stroke, Hemiparesis, Activities of Daily Living
- Trial name
- NCT07760090
- Testing
- Robot-assisted hand rehabilitation, Motor imagery training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uskudar University
Ischemic Stroke
Head Down Position for Successful Recanalization of Anterior Circulation Large Vessel Occlusion (HOPES4)
This is a prospective, randomized, open label, blinded-end point, single-center study, aiming to investigate the effect of head down position in anterior circulation large vessel occlusion patients with successful recanalization…
- Trial name
- NCT06313710
- Testing
- head down position
- Where
- China
- Volunteers
- 90 people
- Sponsor
- General Hospital of Shenyang Military Region
Fabry Disease
Lipidomics and Functional Analyses of Platelets in Fabry Disease
This study aims to evaluate whether platelets are biochemically and functionally altered in Fabry disease (FD) and therefore possibly implicated in FD manifestations such as cerebrovascular events.
- Trial name
- NCT02649660
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Spital Linth
Silent Stroke
Association Between Gait Assessed by Intelligent System and Cognitive Function in Silent Cerebrovascular Disease
This study is a multi-center prospective cohort study. We will continuously recruit subjects with silent cerebrovascular disease aged 60 to 85 years from Shanghai and Guizhou.
- Trial name
- ACCURATE-2 (NCT04456348)
- Testing
- there is no intervention
- Volunteers
- 1,600 people
- Sponsor
- Shanghai Zhongshan Hospital
Ischemic Stroke, Acute, Ischemia-reperfusion Injury
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury
The study is a two-center prospective cohort clinical trial. The primary purpose of this trial is to identify the pattern of DKK2 serum levels in ischemic stroke patients after revascularization therapy and determine the…
- Conditions
- Ischemic Stroke, Acute, Ischemia-reperfusion Injury, Cerebral Edema
- Trial name
- NCT05585255
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Stroke, Acute
Covid-19 Epidemic on Acute Stroke Management
The Covid-19 pandemic is a pandemic of an emerging infectious disease, coronavirus 2019 (Covid-19), caused by the coronavirus SARS-CoV-2.
- Trial name
- Stroke-Covid19 (NCT04370197)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke
Siblings With Ischemic Stroke Study
The purpose of this study is to find the genes that increase the risk of developing an ischemic stroke using DNA samples collected from concordant (stroke-affected) sibling pairs.
- Trial name
- SWISS (NCT00108940)
- Where
- 32 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- Mayo Clinic
Stroke, Transient Ischemic Attack
Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events
The purpose of this study is to assess the effects of a 3-month regimen of clopidogrel initiated with a loading dose (LD) of 300 mg followed by 75 mg/day during the first 21days versus a 3-month regimen of ASA 75 mg/day alone on…
- Trial name
- CHANCE (NCT00979589)
- Testing
- Clopidogrel
- Where
- China
- Volunteers
- 5,100 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Accident
Cardiac Changes Associated With Acute Cerebro-vascular Stroke
Cardiovascular disease is regarded as main predisposing risk factor for cerebrovascular stroke. Cardiac dysfunction can both worsen the pre existing cerebral damage and cause new brain injury Diseases of the heart and the brain…
- Trial name
- NCT05770050
- Testing
- No intervention
- Volunteers
- 145 people
- Sponsor
- Assiut University
Moderate to Severe Hypoxic-ischemic Encephalopathy
Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE
To determine the safety of single and repeated intravenous doses of hCT-MSC in newborn infants with HIE.
- Trial name
- NCT03635450
- Testing
- Infusion of hCT-MSC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Joanne Kurtzberg, MD
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