Clinical trials: Cerebrovascular Diseases
Ischemic Stroke
Impact of Apixaban on Clinical Outcome of the Patients With Large Vessel Occlusion or Stenosis Trial
The aim of this study is to investigate the clinical events of the patients with acute cerebral large vessel occlusion or stenosis and atrial fibrillation, treated by apixaban within 14 days after onset.
- Trial name
- ALVO (NCT02818868)
- Testing
- apixisaban
- Where
- Japan
- Volunteers
- 700 people
- Sponsor
- Hyogo Medical University
Stroke
Instrumental Gait Analysis on People With Stroke After Rehabilitation With a Synchronized FES and Cycle Ergometer System
Functional electrical stimulation is a modality of motor rehabilitation that consists of the programmed application of bursts of electrical current to the affected neuromuscular region that aims to improve muscle strength…
- Trial name
- NCT04473391
- Testing
- Cycle-ergometer training assisted by FES for lower extremities
- Where
- Chile
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Corporación de Rehabilitación Club de Leones Cruz del Sur
ICAS - Intracranial Atherosclerosis, Stroke Ischemic
MPR for Stroke Risk Assessment of ICAS
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve…
- Conditions
- ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
- Trial name
- NCT07309718
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Traumatic Brain Injury, Stroke
Internet Delivered Cognitive Rehabilitation for Mild Cognitive Impairments
Acquired brain injury and neurological disorders cause cognitive deficits, which in turn cause reduced participation in everyday life.
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinsons Disease (PD)
- Trial name
- eRehabCog (NCT06973018)
- Testing
- eRehabCog, CogMed QM
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Aniko Bartfai
Subacute Stroke, Stroke
The Effect of Robotic Rehabilitation in Stroke Patients
The goal of this randomized controlled clinical trial is to investigate the efficacy and safety of adding robot-assisted upper extremity therapy to conventional rehabilitation in patients with early subacute stroke.The primary…
- Conditions
- Subacute Stroke, Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- Hemiplegia (NCT07834255)
- Testing
- Robot-Assisted Upper Extremity Therapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Lokman Hekim University
MELAS, LHON
A Dose-escalating Clinical Trial With KH176
Mitochondrial Diseases are rare progressive, multi-system, often early fatal disorders affecting both children and adults. KH176 is a novel chemical entity currently under development for the treatment of inherited mitochondrial…
- Conditions
- MELAS, LHON, Leigh Syndrome, Mitochondrial Disease
- Trial name
- NCT02544217
- Testing
- KH176
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Khondrion BV
Atrial Fibrillation, Stroke
Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
A prospective, non-blinded, multi-center study to assess the impact of early Catheter Ablation (CA) in patients with a new diagnosis of Atrial Fibrillation(AF) at the time of stroke. 100 patients will be enrolled.
- Trial name
- SAVE STROKE II (NCT06783868)
- Testing
- Catheter Ablation, Market-approved AVNB, OAC and AAD
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Stroke
Implicit Learning in Stroke Study
This trial will compare an Implicit Learning Approach (ILA) to usual care, during the rehabilitation of mobility post stroke. It is a multicentre, assessor blind, cluster randomised controlled pilot trial, with embedded…
- Trial name
- IMPS (NCT03792126)
- Testing
- Implicit Learning Approach
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- The Royal Bournemouth Hospital
Stroke
A Prospective Investigation of the VWF-ADAMTS 13 Axis in Acute Ischaemic Brain Injury (TIAs and Stroke).
In patients presenting with acute stroke or transient ischaemic attacks (TIA), von Willebrand factor related parameters, including VWF antigen, activity, FVIII:c and propeptides, ADAMTS13 levels and VWF multimers in cases where…
- Trial name
- NCT02219035
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Hypoxic Ischemic Encephalopathy
Whole Body Cooling Using Phase Changing Material
A prospective randomized control trial to examine safety and effectiveness of whole body cooling to a rectal temperature of 33.5 C using phase changing material in neonatal encephalopathy.
- Trial name
- NCT01138176
- Testing
- Cooling
- Where
- India
- Volunteers
- 35 people
- Sponsor
- Robertson, Nicola, M.D.
Stroke
Treatment of Chronic Stroke With IpsiHand
The ultimate goal of this project is to develop a functioning and clinically feasible method for restoring function to motor-impaired stroke survivors. This ultimate goal will be approached through two different means.
- Trial name
- NCT02552368
- Testing
- IpsiHand Device
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Carotid Artery Plaques, Atherosclerosis
Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World Study
This study aims to evaluate the effectiveness and safety of Rosa roxburghii freeze-dried powder in reducing carotid atherosclerotic plaques.
- Conditions
- Carotid Artery Plaques, Atherosclerosis, Ischemic Stroke
- Trial name
- RRC-AS (NCT07840950)
- Testing
- Rosa Roxburghii Freeze-Dried Powder, Conventional Anti-Atherosclerosis Therapy
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Stroke
The Effects of Elliptical Cross Training Bike for Stroke Patients
To investigate the effects of elliptical cross bike exercises combine conventional physical therapy on gait, postural control, balance, muscle tone, spasticity, quality of life, motor functioning, functional activity, and ADL in…
- Trial name
- NCT03528148
- Testing
- cycling, Physical therapy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Stroke
Motor Activity and Its Barriers at the Early Phase Post-stroke in Acute Care Setting.
Being active early after stroke prevents secondary complications, reduces hospital length of stay and improves long-term functional outcomes.
- Trial name
- NCT04540978
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- University of Haifa
Stroke, Hemiparesis
Sideways Treadmill Training to Improve Paretic Leg Stepping in Persons Post-Stroke
People who are living in the community following a stroke fall frequently. The ability to take a step in response to a balance disturbance helps to prevent falls but stroke survivors tend not to step with their paretic leg in…
- Trial name
- NCT02516176
- Testing
- treadmill training
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stroke
A Comparison of Conventional Physical Therapy, Powered Exoskeleton, and Hybrid Physical Therapy With Exoskeleton
The purpose of this investigator-initiated study is to establish if powered exoskeleton therapy as a part of a rehabilitation program can be used as a standard of care in stroke rehabilitation.
- Trial name
- NCT04648878
- Testing
- Hybrid combination of physical therapy and powered exoskeleton, Powered Exoskeleton Only, Physical Therapy only
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Loma Linda University
Acute Stroke
CT or MRI in Work up for i.v. Thrombolysis: a Single-centre Study
Acute stroke occurs in approximately 13.000 persons every year in Denmark, 10 - 15 % now receives intervenous thrombolytic therapy, which remains the most important acute treatment in ischaemic stroke.
- Trial name
- NCT02780843
- Testing
- Computerized Tomography, Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 499 people
- Sponsor
- Bispebjerg Hospital
Cardiovascular Diseases, Stroke
Hybrid Stroke Rehab With Mirror Priming
This trial aims to examine the effects of enhanced mirror priming, overcoming the limitations of traditional mirror therapy, to achieve optimization and personalized intervention.
- Conditions
- Cardiovascular Diseases, Stroke, Cerebrovascular Disorders
- Trial name
- NCT07324278
- Testing
- Mirror priming, Conventional therapy
- Where
- Taiwan
- Volunteers
- 81 people
- Sponsor
- I-Shou University
Stroke, Acute Ischemic
Role of Hypothermia in Endovascular Stroke Thrombectomy
Reducing or suspending the increase of the infarcted core, i.e., "freezing" the ischemic penumbra, may help improve the efficacy of mechanical thrombectomy.
- Trial name
- COOLING (NCT06109376)
- Testing
- hypothermia, thrombectomy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Xinqiao Hospital of Chongqing
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH)
Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG
The purpose of this study is to show if it is possible to detect secondary ischemic events in patients with severe brain injury or cerebral haemorrhage with the help of non-invasive near-infrared spectroscopy (NIRS) by using the…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage (ICH), Traumatic Brain Injury
- Trial name
- NCT01836848
- Testing
- measuring cerebral perfusion by NIRS with ICG
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
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