Clinical trials: Cerebrovascular Diseases
Chronic Hemiparetic Stroke
Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke
Stroke is a leading cause of disability in the United States, affecting approximately 795,000 people annually. The Veteran's Health Administration provides over 60,000 outpatient visits for stroke-related care annually at a cost…
- Trial name
- NCT06400186
- Testing
- High intensity gait training in varying external environments, Treadmill walking in varying external environments
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Subarachnoid Hemorrhage, Cerebral Vasospasm
Sildenafil for Prevention of Cerebral Vasospasm
A Randomized Clinical Trial with security and dose testing of Sildenafil Citrate in patients with subarachnoid hemorrhage due to a rupture of a cerebral aneurism for prevention of cerebral vasospasm.
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Rupture of Intracranial Aneurysm
- Trial name
- SIPCEVA (NCT01091870)
- Testing
- Sildenafil Citrate, 25 mg, 3 times a day., Sildenafil Citrate 50 mg, 3 times a day
- Where
- Brazil
- Sponsor
- Hospital de Clinicas de Porto Alegre
Caregivers, Burnout, Psychological
Efficacy of a Multicomponent and Interdisciplinary Intervention on the Care Ability and Burden of Family Caregivers of People With Chronic Cardiocerebrovascular Diseases
The purpose of this intervention is to improve the caregiving ability of family caregivers of people with cardiovascular diseases and therefore reduce burden caregiver through face-to-face, virtual interdisciplinary educational…
- Trial name
- Emiicare (NCT04645290)
- Testing
- Intervention group: Educational Intervention "KARER"
- Where
- 3 sites in Colombia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Claudia Aristizábal
Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended
Coronary artery disease, or narrowing of the blood vessels that provide blood to the heart, is the most common cause of death in the United States and can be treated with either coronary bypass surgery or coronary stent…
- Trial name
- NCT07308860
- Testing
- FFR-guided PCI, CABG
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Spastic Foot, Stroke
Triceps Surae Ultrasonographic Characteristics in Hemiparetic Stroke Survivors
This study aims to evaluate, in hemiparetic patients, changes in muscle ultrasound structure about the focal treatment of spasticity with botulinum toxin type A.
- Trial name
- TriUS (NCT05097482)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Alessio Baricich
Stroke
Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke
The purpose of this trial is to evaluate if it is safe to use tissue plasminogen activator (tPA) within 6 hours of stroke onset when combined with hypothermia.
- Trial name
- NCT00283088
- Testing
- hypothermia, tissue plasminogen activator
- Where
- 7 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
T2DM (Type 2 Diabetes Mellitus), Hypertension
Virtual Diabetes Group Visits Across Health Systems
The purpose of this project is to evaluate the effectiveness of a virtual diabetes group visits on patients with type 2 diabetes mellitus (T2DM).
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Hypertension, Heart Disease Chronic, Stroke
- Trial name
- VIDA (NCT06094491)
- Testing
- Virtual Group Visit
- Where
- 2 sites in United States
- Volunteers
- 720 people
- Sponsor
- University of Chicago
Ischemic Stroke
A Phase 2b Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 2b study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-2 (NCT07645560)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
The Effects of Thoracic Joint Mobilization on Pulmonary Functions of Patients With Stroke
Stroke a neurological disorder leads to long term disability and decline in overall quality of life. Pulmonary Functions are usually impaired in individuals with stroke.
- Trial name
- NCT04188496
- Testing
- Pulmonary Function Test group, Control Group
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Shehla Gul
Stroke
GoHand(TM) to Enhance Recovery of Arm and Hand Function Post-Stroke
This is a proof-of-concept study aimed at contributing evidence towards the need, usability and efficacy potential of the GoHandTM sensor in people with reduced hand function post-stroke.
- Trial name
- GoHand (NCT05321446)
- Testing
- GoHand(TM)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Stroke, Stroke, Acute
Earlier Mobilization Post Acute Thrombolysis
This is a phase III trial trying to determine whether 12-hour bed rest following IV thrombolysis therapy (i.e. tPA) for ischemic stroke is non-inferior to 24-hour bed rest by measure of outcomes on the modified Rankin Scale (mRS)…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- EMPATHY-I (NCT04153942)
- Testing
- Mobilization
- Sponsor
- Brian Silver
Atrial Fibrillation
Global Anticoagulant Registry in the Field
The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF Registry) is a non-interventional, observational study that characterized a global population of non-valvular atrial fibrillation patients.
- Trial name
- GARFIELD-AF (NCT01090362)
- Where
- 35 sites in United States, Argentina and 33 more
- Volunteers
- 57,250 people
- Sponsor
- Thrombosis Research Institute
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to test whether treatment with a drug called Simvastatin prevents and improves outcome in patients who have Subarachnoid bleeding.
- Trial name
- NCT00487461
- Testing
- Simvastatin 40 mg, Simvastatin 80 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois Chicago
Hyperperfusion Syndrome, Moyamoya Disease
Sevoflurane and Hyperperfusion Syndrome
The aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.
- Trial name
- NCT02510586
- Testing
- Sevoflurane
- Volunteers
- 152 people
- Sponsor
- Seoul National University Hospital
Lateral Medullary Syndrome, Deglutition Disorders
The Motor Imagery Based on Action Observation Treatment on Dysphagia in Wallenberg Syndrome
The goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. The main questions it aims to answer are: the efficacy of motor imagery based on action observation treatment in the rehabilitation of…
- Trial name
- NCT06224686
- Testing
- conventional dysphagia treatment, motor imagery based on action observation treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Le Wang
Atrial Fibrillation, Stroke
Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation
This study aims to determine if treatment with apixaban, compared with aspirin, will reduce the risk of ischemic stroke and systemic embolism in patients with device-detected sub-clinical atrial fibrillation and additional risk…
- Trial name
- ARTESiA (NCT01938248)
- Testing
- Apixaban, aspirin
- Where
- 130 sites in United States, Belgium and 11 more
- Volunteers
- 4,012 people
- Sponsor
- Population Health Research Institute
Endocarditis, Stroke
Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per 100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis.
- Trial name
- POMPEI (NCT05378126)
- Testing
- Neurological assessment
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes
Effect of Ischemic Strokes on Recovery From Intracerebral Hemorrhages
Intracerebral hemorrhage (ICH) occurs when small arteries in the brain rupture due to weakening by age, high blood pressure, and/or elevated cholesterol.
- Conditions
- Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes, Diffusion Weighted Imaging Lesions
- Trial name
- NCT01417117
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Rush University Medical Center
Stroke
Effect of Combining Central and Peripheral Cutaneous Electrical Stimulation on Lower Limb Motor Function in People With Stroke
This study aims to evaluate the effectiveness of transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) in augmenting the efficacy of the lower limb task-oriented training in people…
- Trial name
- NCT06838013
- Testing
- Transcranial direct current stimulation (tDCS), Bilateral Transcutaneous electrical nerve stimulation (Bi-TENS), Lower-limb task-oriented training
- Where
- Hong Kong
- Volunteers
- 92 people
- Sponsor
- The Hong Kong Polytechnic University
Stroke
The Neurotrophic Effects of Lithium Carbonate Following Stroke: A Feasibility Study
Stroke is the leading cause of adult disability and the third leading cause of death in Canada. Most stroke survivors live with residual impairments that diminish independence and quality of life.
- Trial name
- NCT01112813
- Testing
- Lithium Carbonate
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Sunnybrook Health Sciences Centre
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