Clinical trials: Cerebrovascular Diseases
Hemorrhagic Stroke
Delipid Extracorporeal Lipoprotein Filter From Plasma (DELP) for Acute Hemorrhagic Stroke
Delipid Extracorporeal Lipoprotein filter from Plasma (DELP) has been found to improve neurological function and life ability of AIS patients and approved for the treatment of AIS by China Food and Drug Administration (CFDA).
- Trial name
- NCT05128513
- Testing
- DELP
- Where
- China
- Volunteers
- 356 people
- Sponsor
- General Hospital of Shenyang Military Region
Cerebral Vein Thrombosis, Cerebral Venous Sinus Thrombosis
Multicenter Registry Study Of Cerebral Venous Thrombosis In China (RETAIN-CH)
This study will investigate the epidemiology, risk factors, diagnostics, treatment, and the long-term prognosis of cerebral venous thrombosis in China.
- Trial name
- NCT05448248
- Where
- China
- Volunteers
- 3,276 people
- Sponsor
- Capital Medical University
Inherited Mitochondrial Disease
A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease
The primary objective of this study is to assess the safety of vatiquinone in participants with inherited mitochondrial disease who had prior exposure to vatiquinone in a PTC/BioElectron sponsored (previously Edison) clinical…
- Trial name
- NCT05218655
- Testing
- Vatiquinone
- Where
- 26 sites in United States, France and 5 more
- Volunteers
- 101 people
- Sponsor
- PTC Therapeutics
Cardiovascular Disease (CVD), Stroke
A Genomic Approach for Clopidogrel in Caribbean Hispanics
Clopidogrel is a prescription medicine used to minimize blood clot formation in patients with cardiovascular disease, particularly those undergoing heart catheterization and stroke.
- Conditions
- Cardiovascular Disease (CVD), Stroke, Acute Coronary Syndrome, Peripheral Arterial Disease
- Trial name
- NCT03419325
- Testing
- CYP2C19 test, P2RY12 assay
- Where
- 2 sites in Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Puerto Rico
Intracerebral Hemorrhage, Neurologic Deficits
Multicenter Registry for Assessment of Markers of Early Neurological Deterioration in Primary Intracerebral Hemorrhage
This multicenter observational study will explore the risk factors of early neurological deterioration(END) in patients with primary and to investigate the association between END and outcome.
- Conditions
- Intracerebral Hemorrhage, Neurologic Deficits, Hemorrhagic Stroke, Hemorrhage
- Trial name
- CATCH (NCT05502874)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sars-CoV2, Severe Neurologic Injury
COVID-19 Brain Injury
A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.
- Conditions
- Sars-CoV2, Severe Neurologic Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT04496076
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Stroke
Community Participation Transition After Stroke
Stroke is one of the most serious, disabling health conditions in the United States. Patients who undergo rehabilitation treatment for stroke have a high rate of disability.
- Trial name
- COMPASS (NCT02396589)
- Testing
- Education Group, Home Modifications Group
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, Stroke
Predictors of Atrial Fibrillation in Patients Undergoing Implantable Loop Recorder Implant
Implantable Loop Recorders (ILR) are small devices the size of a memory stick, which are implanted to investigate stroke, palpitations and fainting episodes.
- Trial name
- NCT04724889
- Testing
- blood test
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Stroke
Unilateral Strength Training and Mirror Therapy for Chronic Stroke Patients
This is a pilot randomised controlled trial investigating a combination of unilateral strength training (cross-education) and mirror therapy for the rehabilitation of lower limb impairment following a stroke.
- Trial name
- NCT03497650
- Testing
- Mirror Therapy, Cross-Education of Strengthening.
- Where
- Ireland
- Volunteers
- 35 people
- Sponsor
- Institute of Technology, Sligo
Stroke, Stroke, Acute
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- TESTED (NCT05911568)
- Testing
- Endovascular Stroke Treatment, Medical Management
- Where
- 35 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- University of Cincinnati
Acute Ischemic Stroke, Tenecteplase
Unknown Time of Onset Stroke RePerfusIon Without Advanced Imaging
The benefit of intravenous tenecteplase for acute ischemic stroke with unknown time of onset, e.g. wake-up stroke, remains uncertain.
- Trial name
- UTOPIA (NCT07475949)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg), Standard medical treatment
- Where
- 15 sites in China
- Volunteers
- 352 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy
Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis
Giant cell arteritis (GCA) is an inflammation of the blood vessels. A dangerous complication is sudden vision loss due to insufficient blood supply to the optic nerve.
- Conditions
- Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
- Trial name
- VISION-GCA (NCT07206238)
- Testing
- Positron Emission Tomography / Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction (MI), Stroke
Smartphone Application to PREDICT Real-Time Cardiovascular Risk for Heart Attack and Stroke
To assess the diagnostic accuracy of a smartphone application in predicting heart attack or stroke within 3-4 days in high-risk patients.
- Trial name
- PREDICT-HS (NCT07735338)
- Testing
- Smartphone application Antshrike
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Stroke
Effect of a Community Exercise Programme on Stroke Patients
Physical activity is known to be beneficial for supporting health and wellbeing. A number of schemes and strategies have been developed to improve uptake of physical activity in the United Kingdom (UK) population, including the…
- Trial name
- NCT05320549
- Testing
- Community Programme
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Winchester
Subarachnoid Hemorrhage, Pneumonia, Bacterial
Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI).
- Trial name
- SAH-CIP (NCT05094349)
- Where
- France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Brest
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Stroke
Navigation Brain Stimulation for Evaluation of the Neuroprotective Drug Efficiency in Patients After Ischemic Stroke.
Ischemic stroke (IS) causes high mortality and severe disability. To improve outcome it's very important to choose the right way of the management of the patient and an appropriate drugs.
- Trial name
- 3C (NCT01388738)
- Testing
- citicoline, L-Alpha glycerylphosphorylcholine, cerebrolysin
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Clinical Institute of the Brain, Russia
Oropharyngeal Dysphagia, Stroke
Effect of a Cooling Sensation Flavor on the Swallow Response in Post-stroke Patients With Oropharyngeal Dysphagia
Current oropharyngeal dysphagia (OD) treatment in older patients is based on compensatory strategies (fluid thickening and texture modified diets) that improve swallow safety but do not improve the swallowing function.
- Conditions
- Oropharyngeal Dysphagia, Stroke, Swallowing Disorder
- Trial name
- NCT06250426
- Testing
- Pre-thickened oral nutritional supplement with a cooling sensation flavour, Pre-thickened oral nutritional supplement without a cooling sensation flavour
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital de Mataró
Stroke, Stroke, Acute
Phase 1 Study to Assess AER-271
The objective of this Phase 1 trial is to assess the safety, tolerability and pharmacokinetics of AER-271 in health subjects.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- NCT03804476
- Testing
- AER-271
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aeromics, Inc.
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