Clinical trials: Cerebrovascular Diseases
Stroke
Non-invasive Measurement of Cerebral Dynamic Autoregulation
The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors.
- Trial name
- TOMCAT (NCT02442856)
- Testing
- Thigh Cuff
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pennsylvania
Stroke, Anosognosia
Improving Awareness for Spatial Neglect With tDCS
Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia.
- Conditions
- Stroke, Anosognosia, Neglect, Hemispatial
- Trial name
- ANOSO (NCT04845529)
- Testing
- transcranial direct current stimulation (tDCS)
- Volunteers
- 12 people
- Sponsor
- University of Geneva, Switzerland
Stroke, Hemiplegia
Rehabilitation of Early Stroke Patients Using an AFO: an RCT
Stroke is a major cause of disabilities worldwide. Stroke survivors commonly exhibit walking defects which lead to an altered, slow speed and asymmetric gait pattern.
- Trial name
- NCT01006772
- Testing
- Solid Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Strathclyde
Acute Ischemic Stroke
Study to Assess PK, Safety and Tolerability Early in Healthy Subjects
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of QHRD106 early in Chinese healthy subjects with single doses.
- Trial name
- NCT06388772
- Testing
- QHRD106 Injection
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Changzhou Qianhong Bio-pharma Co., Ltd.
Respiratory Muscles, Stroke
The Effect of Functional Inspiratory Muscle Training Versus Inspiratory Muscle Training
This study aims to compare the effectiveness of functional inspiratory muscle training (IMT) versus inspiratory muscle training on trunk control, respiratory parameters, activity, and participation in chronic stroke patients.
- Trial name
- NCT06454539
- Testing
- Functional Inspiratory Muscle Training, Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Istinye University
Hypoxic-Ischemic Encephalopathy, Pain
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
Management of neonatal pain and sedation often includes opioid therapy. A growing body of evidence suggests long-term harm associated with neonatal opioid exposure.
- Trial name
- DICE (NCT04772222)
- Testing
- Dexmedetomidine Hydrochloride, Morphine Sulfate
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis
DOAC in Unusual Site Venous Thrombosis
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein…
- Conditions
- Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis
- Trial name
- DUST (NCT03778502)
- Testing
- Direct Oral Anticoagulants
- Where
- 24 sites in United States, Canada and 8 more
- Volunteers
- 358 people
- Sponsor
- University of Malta
Giant Cell Arteritis
Tocilizumab for Patients With Giant Cell Arteritis
Giant-cell arteritis (GCA) is an immune-mediated disease that mostly affects people older than 50 years of age. Glucocorticoid (GC) treatment dramatically alters the symptoms and course of GCA, reducing the likelihood of vascular…
- Trial name
- NCT01450137
- Testing
- Tocilizumab + Glucocorticoids (GCs)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischemic Stroke
Cooling Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke
The purpose of this study is to determine if systemic cooling to a target temperature of 34 to 35°C, started within 6 hours of symptom onset and maintained for 12 hours, improves functional outcome at 3 months in patients with…
- Trial name
- EuroHYP-1 (NCT01833312)
- Testing
- Hypothermia, Buspirone, Pethidine
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Dementia
Research on the Early and Prognosis Diagnosis of Vascular Dementia
Around 10% of stroke survivors develop dementia within 3 months after stroke and over 20% more stroke patients have dementia in the subsequent 3 years.
- Trial name
- NCT03152630
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Acute Ischemic Stroke
ANAIS Study to Confirm the Safety and Performance of the ANA 5F Advanced Neurovascular Access®
Prospective, single-arm, multi-center study to assess the safety and performance of the ANA 5F Advanced Neurovascular Access®, in combination with a stent retriever in patients with acute ischemic stroke.
- Trial name
- ANAIS (NCT05409430)
- Testing
- Neurothrombectomy
- Where
- 3 sites in Spain
- Volunteers
- 43 people
- Sponsor
- Anaconda Biomed S.L.
Stroke
Effects of Transcranial Magnetic Stimulation Associated to Sensory Therapy for Treatment of Motor Function of Upper Limb of Stroke Patients
The aim of this research will be to investigate in stroke patients whether upper limb motor function can be maximized in response to sensory stimulation by comparing protocols for the application of Transcranial Magnetic…
- Trial name
- NCT03329807
- Testing
- Transcranial Magnetic Stimulation, conventional sensory therapy
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal de Pernambuco
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Encephalopathy, Ischemic
End-of-life Intervention for African American Dementia Caregivers
In a community-based approach, the investigators long-term goal is to empower African American family caregivers who are designated healthcare proxies to make informed end-of-life treatment decisions for participants with…
- Trial name
- NCT03323411
- Testing
- Advance Care Treatment Plan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Stroke
Balance Training After Stroke - a Randomized, Controled Pilot Study
This pilot study is part of a master's thesis. In the rehabilitation of stroke patients should be compared whether individual balance training has a greater effect than group balance training.
- Trial name
- NCT03791671
- Testing
- individual balance training, group balance training
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- RehaClinic AG
Stroke
Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment
People with post-stroke aphasia are left with some degree of chronic deficit for which current rehabilitative treatments are variably effective.
- Trial name
- NCT02901574
- Testing
- Anodal or Cathodal tDCS, Computerized naming therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Stroke
Action Observation Treatment on Motor Function in Upper Limb of Patients With Chronic Stroke
To determine the effects of action observation treatment on motor functions in upper limb of patients with chronic stroke
- Trial name
- NCT05084820
- Testing
- Action observation treatment, conventional treatment
- Where
- Pakistan
- Volunteers
- 14 people
- Sponsor
- Riphah International University
Acute Stroke
Predictive Factors Of Acute Ischemic Stroke Outcome in Adult
Stroke is a devastating disease that affects 15 million patients worldwide each year, resulting in death in about one-third of patients and severe disability in two-thirds of the survivors.
- Trial name
- NCT03700879
- Testing
- MRI,MRA,Carotid ,vertebrobasilar and Transcranial Doppler
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiac Arrest (CA), Cerebrospinal Fluid
Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics
The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.
- Conditions
- Cardiac Arrest (CA), Cerebrospinal Fluid, Multiomics, Hypoxic-Ischemic Brain Injury
- Trial name
- PCABI-OMICS (NCT07481396)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Chungnam National University Hospital
Stroke
Transcranial Direct Current Stimulation (tDCS) in Chronic Stroke Recovery
The hypothesis of this study is that different subgroups of stroke will respond differently to direct current stimulation.
- Trial name
- NCT01014897
- Testing
- tDCS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
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