Clinical trials: Cerebrovascular Disorders, open to volunteers
Stroke Rehabilitation, Gait Disorders, Neurologic
Efficacy of Cerebello-spinal Direct Current Stimulation (csDCS) on Functional Mobility in Chronic Stroke Patients
The aim of this clinical trial is to determine if cerebello-spinal direct current stimulation (csDCS) is effective in treating gait disorders in individuals with chronic stroke.
- Conditions
- Stroke Rehabilitation, Gait Disorders, Neurologic, tDCS
- Trial name
- NCT07073287
- Testing
- Cerebello-spinal direct current stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Stroke, Stroke Sequelae
Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors
The proposed study is a two-arm randomized clinical trial designed to assess the effects of the StrokeWear system on clinical outcomes over a period of 6-months in chronic stroke survivors.
- Conditions
- Stroke, Stroke Sequelae, Hemiparesis;Poststroke/CVA
- Trial name
- NCT05626894
- Testing
- StrokeWear Motor and Behavioral Intervention, Usual Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Spaulding Rehabilitation Hospital
Acute Ischemic Stroke
Sublingual Edaravone Dexborneol for Inter-hospital Transfer Acute Ischemic Stroke (SLEDAIS)
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial (SLEDAIS) involving 1,040 patients with acute ischemic stroke (AIS) who require inter-hospital transfer for potential endovascular therapy.
- Trial name
- SLEDAIS (NCT07682922)
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- Xinqiao Hospital of Chongqing
Ischemic Stroke
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic…
- Trial name
- NCT07498777
- Testing
- Active Individual Alpha Frequency-based Repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Abnormalities, Arterial Blood Pressure
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
The aim of the study is to characterise the cardiovascular and metabolic complications pre- and post-surgery of patients with biochemically negative PPGL and to compare them with normal individuals and patients with secreting…
- Conditions
- Cardiovascular Abnormalities, Arterial Blood Pressure, Heart Rate, Congestive Heart Failure Chronic
- Trial name
- NCT07316075
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Stroke, Transient Ischemic Attack
Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical…
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Intracranial Arterial Stenosis
- Trial name
- ANFIS (NCT04240119)
- Testing
- According to current clinical care standards
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Hemiparesis
Mechanisms of Open and Hidden Placebo in Stroke Recovery
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance…
- Trial name
- NCT05832567
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Spaulding Rehabilitation Hospital
Fabry Disease
A Study of Patients With Fabry Disease (US Specific)
This is an observational study to evaluate the effects of treatment on long-term effectiveness, safety, and health-related quality of life (HRQOL) in patients with Fabry disease, with a main focus on migalastat.
- Trial name
- NCT06906367
- Testing
- migalastat HCl, ERT
- Where
- 8 sites in United States
- Volunteers
- 450 people
- Sponsor
- Amicus Therapeutics
Ischemic Stroke, Thrombolysis
Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses.
- Trial name
- NCT07299981
- Testing
- No Interventions
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Sigmund Freud PrivatUniversitat
Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases
Cerebral Arteriovenous Malformation With Aneurysm: Epidemiology, Clinical Features, and Prognosis
The study is a multicenter, prospective cohort study designed to assess the natural history, clinical safety and efficacy of various treatment strategies in patients with cerebral arteriovenous malformations (AVMs) and…
- Conditions
- Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases, Intra Cerebral Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT07353736
- Where
- China
- Volunteers
- 630 people
- Sponsor
- Duan Chuanzhi
Vertebral Artery Stenosis
Drug Eluting Stenting and Short Dual Antiplatelet Therapy for Preventing Recurrent Stroke in Vertebral Stenosis Registry Study
This is a prospective, multi-center, registry study exploring the duration of dual antiplatelet therapy (DAPT) after drug-eluting stent(DES) treatment of symptomatic vertebral artery atherosclerotic stenosis.
- Trial name
- M Short DAPT (NCT06683300)
- Testing
- DAPT for 3 months after vertebral artery stenting
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Dyslexia, Acquired
Acquired Dyslexia Modeling and Treatment
This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment.
- Trial name
- AMT (NCT07209488)
- Testing
- Phono-Motor Therapy, Semantic Feature Analysis
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Rutgers, The State University of New Jersey
Intracerebral Haemorrhage, Minimally Invasive Treatment
Stereotactic Thrombolysis With Tenecteplase for Supratentorial Intracerebral Hemorrhage
This is a phase III prospective, multi-center, open-label, randomized controlled trial (RCT) with blinded endpoint assessment. It plans to enroll 768 subjects with spontaneous supratentorial intracerebral hemorrhage, who will be…
- Trial name
- STEPS (NCT07208097)
- Testing
- Stereotactic thrombolysis with Tenecteplase
- Where
- 51 sites in China
- Volunteers
- 768 people
- Sponsor
- Tongji Hospital
Stroke
Effect of Lower Limb Proprioceptive Neuromuscular Facilitation Combined With Core Stability Training Versus Proprioceptive Neuromuscular Facilitation Alone on Balance and Functional Mobility in Chronic Stroke Survivors
This randomized controlled trial compares lower limb proprioceptive neuromuscular facilitation (PNF) combined with core stability training versus lower limb PNF alone in chronic stroke survivors.
- Trial name
- NCT07887360
- Testing
- Lower Limb PNF Combined with Core Stability Training, Lower Limb PNF alone
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Ibadat International University, Islamabad
Stroke, Acute, Stroke, Ischemic
Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Rationale: Approximately 20% of the patients with acute ischemic stroke due to an intracranial large vessel occlusion (LVO) has a high-grade stenosis in the ipsilateral cervical carotid artery.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Carotid Stenosis, Carotid Atherosclerosis
- Trial name
- CASES (NCT06511089)
- Testing
- carotid artery stenting during EVT, no carotid artery stenting during EVT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- University Medical Center Groningen
Stroke (CVA) or Transient Ischemic Attack
Comparative Effects of Sensory Augmentation and Neuromodulation on Enhancing Motor Recovery Among Stroke Survivors
This study aims to evaluate the effectiveness of two rehabilitation techniques-Sensory Augmentation (using mirror therapy) and Neuromodulation (using transcranial direct current stimulation, tDCS)-in improving motor recovery…
- Trial name
- NCT07266662
- Testing
- Sensory Augmentation, Neuromodulation, Combination of Sensory Augmentation and Neuromodulation
- Where
- 2 sites in Pakistan
- Volunteers
- 36 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Stroke, Visual Impairment
Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance
The goal of this clinical trial is to evaluate the effectiveness of an immersive virtual-reality (IVR) based stimulation program, in improving visual perception for people who have lost their driver's license due to perceptual or…
- Conditions
- Stroke, Visual Impairment, Low Vision, Virtual Reality
- Trial name
- Re:DriVR (NCT05703360)
- Testing
- Audiovisual Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Intracerebral Hemorrhage
Optimization of the Management of Non-Traumatic Intracerebral Hemorrhage (OPT-ICH)
Intracerebral non-traumatic intraparenchymal hemorrhages (ICH) account for 15 to 20% of strokes. One third of the patients dies within the month following ICH, and survivors often experience residual disability with a high risk…
- Trial name
- OPT-ICH (NCT06802588)
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Tours
Stroke
Effects of Otago Exercises and Systematic Desensitization on Balance,Fall Risk and Basophobia Among Post Stroke Patients
The aim of the study is to determine the combined effects of Otago exercises and systematic desensitization on balance, fall risk, and basophobia among post-stroke older adults.
- Trial name
- NCT07063368
- Testing
- Otago exercises and systematic desensitization with routine physical therapy, Otago Exercises and Routine physical Therapy, Systematic desensitization and routine physical therapy
- Where
- Pakistan
- Volunteers
- 51 people
- Sponsor
- Riphah International University
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