Clinical trials: Cerebrovascular Regulation
Healthy
Evaluating Q-Collar Effects on Brain Blood Flow Control During Exercise
The goal of this clinical trial is to learn how the FDA-cleared Q-Collar device affects brain blood flow regulation during rest and exercise in healthy adults. The main questions this study aims to answer are: 1.
- Trial name
- NCT06826781
- Testing
- Q30 Q-Collar, Not wearing Q-Collar
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Infarction
Research on Binaural Synchronous Vagus Nerve Regulation of Sensorimotor Disorders After Cerebral Infarction
The aim of this study is to determine the efficacy and safety of binaural synchronous vagus nerve regulation in the treatment of patients with sensory and motor dysfunction after cerebral infarction through a randomized…
- Trial name
- NCT07081568
- Testing
- transcutaneous auriculai vagus nerve stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanchang University Affiliated Rehabilitation Hospital
Infant, Very Low Birth Weight, Infant, Premature, Diseases
Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants
Advances in newborn intensive care have lead to dramatic improvements in survival for the most premature infants-often weighing 1 pound at birth.
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Diseases, Cerebral Hemorrhage
- Trial name
- NCT00579943
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arkansas
Cerebrovascular Accident, Baroreflexes
Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke
After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general.
- Conditions
- Cerebrovascular Accident, Baroreflexes, Autonomic Nervous System Diseases
- Trial name
- NCT00422474
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Stroke
Self-regulated Constraint-induced Movement Therapy in Subacute Stroke Patients
Emerging research suggests the use of self-regulation (SR) strategies at improving functional regain in patients with brain injury.
- Trial name
- NCT02480140
- Testing
- Self-regulated constraint-induced movement therapy, Constraint-induced movement therapy, Conventional occupational therapy
- Where
- 2 sites in Hong Kong
- Volunteers
- 76 people
- Sponsor
- University of Western Sydney
Stroke
Causal Evidence for Task Regulation by Anterior Cingulate Cortex
The exact function of the anterior cingulate cortex (ACC) is one of the largest riddles in cognitive neuroscience and a major challenge in mental health research.
- Trial name
- NCT04650425
- Testing
- Cognitive tasks
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Stroke
Blood Flow Regulation and Neuromuscular Function Post-Stroke
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking.
- Trial name
- NCT06027294
- Testing
- Ischemic Conditioning
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Cerebrovascular Regulation
Brain Blood Flow Responses at Rest and During Exercise
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flow to match this.
- Trial name
- NCT06142045
- Testing
- RespirACT RA-MR System
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Parkinson Disease (PD)
Synthetic Vasomotion for Glymphatic Enhancement
The goal of this pilot clinical trial is to learn whether a week-long study combining controlled breathing procedures, intermittent exposure to a low-concentration carbon dioxide gas mixture, and noninvasive vagus nerve…
- Trial name
- NCT07814534
- Testing
- Active noninvasive vagus nerve stimulation, Active intermittent hypercapnia, Guided breathing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke
Peer Group Regulated mCIMT Program for Adult Stroke Patients: Effects on Functional Activities
Each year more than 17 million people in the world are experiencing a stroke. Stroke is a major cause of mortality and one of the prevalent causes of serious disablement.
- Conditions
- Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke, Upper Extremity Functional Performance After Stroke
- Trial name
- PEPS-MIT (NCT04264195)
- Testing
- Constraint-induced movement therapy: PEPS-MIT, Bimanual manipulation exercises (PEPS-Bimanual)
- Where
- Bangladesh
- Volunteers
- 140 people
- Sponsor
- Centre for the Rehabilitation of the Paralysed, Bangladesh
Cerebral Arterial Diseases
Human Cerebral Blood Flow Regulation
To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases.
- Trial name
- Gas Challenge (NCT04265053)
- Testing
- Indomethacin 25 MG/50 MG
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Sleep Disorders, Intrinsic
Cerebral Hemodynamics in Sleep Disorders
The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.
- Trial name
- NCT02752139
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Quadrantectomies, Spinal Fusion
Complementary and Alternative Medicine Interventions in Targeting Pain
This Controlled Randomized Clinical Trial aimed at determining the effectiveness of a modified RR intervention in reducing post-operative pain and psychological symptoms in patients undergoing surgery intervention.
- Conditions
- Quadrantectomies, Spinal Fusion, Carotid Stenosis, Abdominal Aortic Aneurysm
- Trial name
- CAMP (NCT04845334)
- Testing
- RR intervention
- Volunteers
- 128 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Atrial Fibrillation, Arrhythmia
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age.
- Trial name
- NCT04766814
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tulane University