Clinical trials: Cerebrovascular Stenosis
Carotid Stenosis, Cerebral Hyperperfusion Syndrome
Accuracy of TCD Monitoring in Predicting Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy
Background: Cerebral hyperperfusion syndrome (CHS) is a life threatening complication of carotid endarterectomy (CEA) and the changes of middle cerebral artery velocity are used to predict the occurrence of CHS but the accuracy…
- Conditions
- Carotid Stenosis, Cerebral Hyperperfusion Syndrome, Blood Pressure
- Trial name
- NCT01799070
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Stenoses, Carotid
CREST-2 Long-term Observational Extension Study
The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE - ClinicalTrials.gov Identifier: NCT02089217) study is to study is to assess post-procedural efficacy of…
- Trial name
- C2LOE (NCT05465122)
- Testing
- Carotid Endarterectomy, FDA-approved carotid stents, Intensive Medical Management
- Where
- 64 sites in United States, Canada and 1 more
- Volunteers
- 2,480 people
- Sponsor
- Mayo Clinic
Infarction, Stroke
Polymorphisms in the Vitamin D System and Health
Polymorphisms in the vitamin D system appear to affect the serum 25(OH)D levels. If so one would expect these polymorphisms to be associated with vitamin D related conditions and diseases, which will be tested in the present…
- Conditions
- Infarction, Stroke, Diabetes, Fracture
- Trial name
- NCT01395303
- Where
- Norway
- Volunteers
- 9,700 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Ischemic Stroke
Clinical Registration Trial of Intracranial Stenting for Patients With Symptomatic Intracranial Artery Stenosis(CRTICAS)
This trial is an prospective, government-funded registration study that will observe the safety and effectiveness of intracranial stenting for preventing stroke during a mean follow-up of 12 months in patients with symptomatic…
- Trial name
- NCT01994161
- Testing
- intracranial stenting
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital
TIA, Carotid Artery Plaque
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
- Conditions
- TIA, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- ELLIPSE (NCT05975554)
- Testing
- Interleukin-2 [IL-2], Standard care - Carotid Endarterectomy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Carotid Stenosis, Ischemic Stroke
Symptomatic Carotid Outcomes Registry
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications.
- Conditions
- Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- SCORE (NCT05300737)
- Testing
- intensive medical therapy
- Where
- 18 sites in United States, Canada
- Volunteers
- 114 people
- Sponsor
- University of Maryland, Baltimore
Intracranial Arteriosclerosis, Stroke (CVA) or TIA
Evaluating the Safety and Efficacy of the Maurora® DES in ICAS
The purpose of the RCT trial is to evaluate whether implantation of drug-eluting stent (DES) is more efficacious than bare metal stent (BMS) in prevention of in-stent restenosis (ISR) and improvement of outcomes for symptomatic…
- Trial name
- Maurora ICAS (NCT05719883)
- Testing
- Maurora® Sirolimus Eluting Stent System, APOLLO™ Intracranial Stent System
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Embolization During TAVI Using Balloon-expandable vs. Self-expandable Valves
PROTECT TAVI - Prospective Randomized Outcome Study in TAVI Patients Undergoing Periprocedural Embolic Cerebral Protection With the Sentinel™ Device
This prospective, randomized study was designed to analyse the difference of cerebral embolization in patients undergoing transcatheter aortic valve implantation with balloon-expandable vs.
- Trial name
- PROTECT (NCT02895737)
- Testing
- TAVI: Edwards SAPIEN 3, Edwards Lifesciences, Edwards Sapien Ultra, TAVI: Edwards SAPIEN 3, Edwards Lifesciences, Edwards Sapien Ultra; Sentinel™ Cerebral Protection Systems, TAVI: CoreValve® Evolut R™, CoreValve Medtronic
- Where
- Germany
- Volunteers
- 328 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Carotid Artery Stenosis
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid…
- Trial name
- CAROTEP (NCT03353103)
- Testing
- Sodium fluoride F-18 PET imaging
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Ischemic Stroke, Atrial Fibrillation
Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)
The main aim of the study is to investigate the prevalence and characteristics of ischemic stroke patients with atrial fibrillation and concurrent carotid atherosclerosis.
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Carotid Stenosis
- Trial name
- AFCAS (NCT04821700)
- Testing
- Carotid Stenosis
- Where
- Greece
- Volunteers
- 3,000 people
- Sponsor
- University of Thessaly
Carotid Artery Stenosis
Effect of Carotid Artery Stent on Evoked Cerebral Blood Oxygenation and Neurocognitive Functioning
Cerebral hemodynamic compromise from internal carotid artery stenosis may be a cause of vascular cognitive impairment that is amenable to treatment by revascularization.
- Trial name
- NCT04651998
- Testing
- MMSE, MoCA, functional near-infrared spectroscopy
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Carotid Artery Plaque, Ischemic Stroke
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke.
- Conditions
- Carotid Artery Plaque, Ischemic Stroke, PET / MR
- Trial name
- NCT07004673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Coronary Stenosis, Cerebral Stenosis
Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
- Trial name
- NCT02315924
- Testing
- simultaneous coronary and cerebral intervention, staged coronary and cerebral intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Coronary Artery Disease, Arteriosclerosis
Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?
Diabetes Mellitus (DM) is frequently appearing in patients with cardiovascular disease and these patients, as a consequence herby, has a lesser prognosis. DM is often related to increased arterial stiffness and hypertension.
- Conditions
- Coronary Artery Disease, Arteriosclerosis, Carotid Stenosis, Thrombosis
- Trial name
- NCT01106573
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Odense University Hospital
Vertebral Artery Stenosis
Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)
A retrospective and prospective registry of patients admitted for stroke and evidence of Vertebral Artery Origin Stenosis (VAOS).
- Trial name
- VOTER (NCT03999983)
- Testing
- Observational Prospective Registry
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- St. Louis University
Carotid Artery Stenosis
Gao's Triple Eversion Carotid Endarterectomy
Carotid endarterectomy (CEA), an important surgical approach for managing carotid plaque, has evolved over more than 70 years but still cannot be applied to all tandem carotid lesions (TCLs) because of the wide range of these…
- Trial name
- NCT06722222
- Testing
- Gao's triple eversion carotid endarterectomy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carotid Artery Stenosis
Enterprise Stent Implantation in the Treatment of Carotid Artery Stenosis With Ischemic Stroke
To investigate the long-term effects of intracranial implantation of Enterprise stent system versus antiplatelet medication on neurologic deficits, daily living abilities, and carotid artery stenosis in patients with…
- Trial name
- NCT02802072
- Testing
- Enterprise stent implantation, Only aspirin medication
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Fabry Disease
Cardiac Involvement in Adult Patients With Fabry Disease; Relation to Enzyme Replacement Therapy
The purpose of this study was to assess the progression of cardiac involvement in adult patients with Fabry Disease (FD), in the unique Danish Fabry cohort and comparing those FD patients receiving primary therapy vs.
- Trial name
- NCT02908724
- Volunteers
- 66 people
- Sponsor
- Ulla Feldt-Rasmussen