Clinical trials: Cervical
Chemoradiation, Nasopharyngeal Carcinoma
Efficacy Study of Neoadjuvant Chemotherapy With Chemoradiation Therapy for Nasopharyngeal Carcinoma
Locally advanced nasopharyngeal carcinoma patients(UICC7th stageIII to IVb) will receive either cisplatin plus 5-fluorouracil (PF) or docetaxel plus cisplatin and 5-fluorouracil(TPF) neoadjuvant chemotherapy with concurrent…
- Trial name
- ESNCCT (NCT01536223)
- Testing
- PF (cisplatin and 5-fluorouracil) group, TPF (docetaxel plus cisplatin and 5-fluorouracil) group
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Zhejiang Cancer Hospital
Advanced Solid Tumor
Study of ZGGS18 in Combination With ZG005 in Patients With Advanced Solid Tumors
This trial is designed to assess the tolerability, safety, pharmacokinetic profile, and preliminary efficacy of the combination of ZGGS18 and ZG005 in patients with advanced solid tumors, including advanced cervical cancer…
- Trial name
- NCT06938880
- Testing
- ZGGS18 for Injection, ZG005 for Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Carotid Stenosis
Study of Carotid Artery Stenosis Through the Integration of Multimodal Imaging and Computational Fluid Dynamics
Ischemic stroke affects 2.5 to 3 million people annually in China, ranking as the leading cause of death and disability. Cervical artery stenosis is a significant contributor to this problem, with about 50% of patients…
- Trial name
- NCT06294496
- Testing
- CEA/CAS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sichuan Provincial People's Hospital
Aortic Arch Aneurysm
Homemade Fenestrated Physician-modified Stent-grafts for Arch Aortic Degenerative Aneurysm
The aim was to evaluate early and medium-term outcomes of single and double fenestrated physician-modified endovascular grafts (PMEGs) for endovascular aortic arch degenerative aneursym repair.
- Trial name
- NCT04809896
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Cervical Cancer, Precancerous Condition
Fluorescence and Reflectance Spectroscopy During Colposcopy in Detecting Cervical Intraepithelial Neoplasia and Dysplasia in Healthy Participants With a History of Normal Pap Smears
RATIONALE: New diagnostic procedures such as fluorescence and reflectance spectroscopy (shining light on tissue and measuring patterns of light reflected) may improve the ability to noninvasively detect cervical intraepithelial…
- Trial name
- NCT00084903
- Testing
- Colposcopic biopsy, Light-Scattering Spectroscopy
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,070 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Dental Diseases
Evaluation of the Initial Color Match of Different Single-shade Composites
The aim of this study was to evaluate the initial colour match of anterior non-carious cervical lesions restored with different single-shade resin composites, namely Omnichroma (Tokuyama) and Charisma Topaz One (Kulzer).
- Trial name
- NCT06473727
- Testing
- Omnichoroma, Charisma Topaz One
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma
Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CT
This study aims to evaluate the role of early response assessment by 18F-FDG PET/CT in patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma with PD-L1 CPS >1 treated with pembrolizumab…
- Trial name
- PEMBRO-PET (NCT07448727)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Rome Tor Vergata
Head and Neck Cancer, Squamous Cell Carcinoma of the Head and Neck
Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC
This is an open-label, randomized, phase II trial to test the efficacy of Ibrutinib in combination with either Nivolumab or Cetuximab in the treatment of recurrent and/or metastatic head an neck squamous cell carcinoma
- Trial name
- NCT03646461
- Testing
- Ibrutinib 560mg PO daily (Imbruvica), Cetuximab, Nivolumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Esophageal Squamous Cell Carcinoma (ESCC)
A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
The purpose of this study is to evaluate the efficacy and safety of tislelizumab as first line treatment in combination with chemotherapy in participants with advanced unresectable/metastatic esophageal squamous cell carcinoma…
- Trial name
- NCT03783442
- Testing
- Cisplatin, Oxaliplatin, Fluorouracil (5-FU)
- Where
- 124 sites in United States, Australia and 14 more
- Volunteers
- 649 people
- Sponsor
- BeiGene
Head and Neck Cancer
Contrast Between Traditional Regression Model and AI in Predicting Prolonged Stay Stay After Head and Neck Tumors
This experiment is an observational study of cohort. By establishing a cohort of patients with head and neck tumors transferred to ICU after surgery, investigators compared the prediction effect of AI and the traditional…
- Trial name
- NCT06570486
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Radiculopathy
Effects of Slider Versus Tensioners Nerve Gliding in Cervical Radiculopathy.
This study will be a randomized clinical trial in which Slider versus Tensioners Nerve Gliding Technique along with Mulligan Spinal Mobilization will be applied on the individuals with cerviculorediculopathy and changes will be…
- Trial name
- NCT06339970
- Testing
- Slider Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique, Tensioners Nerve Gliding Technique along with Mulligan Spinal Mobilization Technique
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Intubation, Intratracheal, Pain, Postoperative
Tracheal Tube Cuff Shape and Pressure
This is a randomized controlled trial focusing on the effect of different tracheal tube cuff shape; the tapered-shaped tracheal tube cuff versus the cylindrical-shaped tracheal cuff in anterior cervical spine surgery.
- Conditions
- Intubation, Intratracheal, Pain, Postoperative, Dysphonia
- Trial name
- NCT04591769
- Testing
- Different tracheal tube cuff design
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Head and Neck Cancer
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT01220583
- Testing
- cisplatin, 3-dimensional conformal radiation therapy, intensity-modulated radiation therapy
- Where
- 268 sites in United States, Canada and 1 more
- Volunteers
- 252 people
- Sponsor
- Radiation Therapy Oncology Group
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced Esoph and Gastro-esoph Jction CA
ARTemIS-Eso is a phase I-II, three-level, open-label trial with a dose-expansion cohort at recommended schedule in both esophageal cancer histological groups (squamous cell carcinoma and adenocarcinoma) of RCT and ImT…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Squamous Cell Carcinoma of the Esophagus
- Trial name
- ARTEMIS-Eso (NCT03307941)
- Testing
- Monalizumab, Oxaliplatin, 5-Fluorouracil
- Where
- Belgium
- Sponsor
- Jules Bordet Institute
Head Cancer
Evaluation of Quality of Life and Self-assurance and Social Support Earned for Non-cellular Head Cancer
Research objectives: To evaluate the quality of life of patients before and after surgery for benign head tumors ( meningiomas) and malignant tumors at stage I, II and III, to assess whether it depends on the size of the tumor…
- Trial name
- NCT06395805
- Testing
- BREF, ADL, AIS.
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Esophageal Cancer
Nimotuzumab Combined With Sintilimab and Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma
This study is a prospective, single-arm, multicenter study. The patients were given chemotherapy with nimotuzumab and sindilimab.
- Trial name
- NCT06718205
- Testing
- Nimotuzumab, Sintilimab, Paclitaxel-albumin
- Where
- China
- Volunteers
- 112 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
AIS, Cervical Alignment
Cervical Alignment Changes After Correction of Thoracic Adolescent Idiopathic Scoliosis With Thoracic Hypokyphosis
The sagittal alignment of Adolescent Idiopathic Scoliosis (AIS) curves has attracted growing interest in recent years, to the extent that it has become a pivotal point in the Lenke classification, with the introduction of a…
- Conditions
- AIS, Cervical Alignment, Thoracic Kyphosis
- Trial name
- NCT06251505
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Istituto Ortopedico Rizzoli
Locally Recurrent Cancer, Metastatic Nasopharyngeal Cancer
Bevacizumab and Pembrolizumab Combination in Platinum-resistant Recurrent/Metastatic NPC
This is a single center, randomized, phase Ib/II open-label study of pembrolizumab (pembro or MK-3475) with or without bevacizumab in patients with recurrent non-curable or metastatic nasopharyngeal carcinoma (NPC).
- Trial name
- 2018/00947 (NCT03813394)
- Testing
- pembrolizumab, bevacizumab
- Where
- Singapore
- Volunteers
- 48 people
- Sponsor
- National University Hospital, Singapore
Neck Pain, Pain Knowledge
Reliability of the Neurophysiology of Pain Questionnaire in the Neck Pain the Cross-validation Study
The aim of this study is to study the validity and reliability of the Modified Pain Neurophysiology Questionnaire in patients with neck pain.
- Trial name
- NCT05606666
- Testing
- reliability of the NPQ
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Head and Neck Squamous Cell Carcinoma
A Comparative Study of Efficacy and Safety of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma
The primary objective of the study is to evaluate the comparability of efficacy, safety, and immunogenicity of RPH-002 and Erbitux® when administered in combination with docetaxel and cisplatin as first-line therapy in patients…
- Trial name
- NCT07435324
- Testing
- RPH-002, Erbitux®, Cisplatin
- Where
- 34 sites in Russia, Uzbekistan
- Volunteers
- 161 people
- Sponsor
- R-Pharm