Clinical trials: Cervical Cancer Radiation Complications
Cervical Cancer
Hydrogel Spacer During Definitive Radiotherapy for Cervical Cancer
This prospective, single-center study will evaluate the feasibility, spatial stability, and dosimetric effects of an absorbable hydrogel spacer placed between the cervix/vagina and rectum before definitive radiotherapy for…
- Trial name
- Hydrogel-RT (NCT07904182)
- Testing
- Absorbable Hydrogel Spacer
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cervical Cancer, Gynecologic Cancer
Spatially Fractionated Radiation Treatment for Gynaecological Cancers
This is a prospective study to evaluate in-field disease control, survival and late toxicity in patients with cervical cancer or pelvic recurrence treated with spatially fractionated RT.
- Conditions
- Cervical Cancer, Gynecologic Cancer, Recurrent Cancer
- Trial name
- NCT06644846
- Testing
- Spatially fractionated radiation therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Tata Memorial Hospital
Cervical Cancer
Magnetic Resonance Imaging-Based Radiation Therapy and Cisplatin in Patients With Stage I, Stage II, Stage III, or Stage IV Cervical Cancer
Rationale: Computer systems that allow doctors to create a 3 dimensional (3-D) picture of the tumor may help in planning radiation therapy and may result in more tumor cells being killed.
- Trial name
- NCT01016561
- Testing
- intracavitary balloon brachytherapy, external beam radiation therapy, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cervical Cancer
Online Adaptive Radiotherapy for Cervical Cancer
This study aims to evaluate the clinical efficacy and safety of online adaptive radiotherapy for cervical cancer patients received radical radiotherapy.
- Trial name
- NCT06562166
- Testing
- online adaptive radiotherapy
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking Union Medical College Hospital
HNSCC, NSCLC
Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and Radiotherapy
Inhibitors of the programmed cell death protein 1 (PD-1)/PD-L1 immune checkpoint signaling pathway are already approved in the treatment of various tumor entities in relapsed or metastatic stages.
- Conditions
- HNSCC, NSCLC, Esophageal Cancer, Urothelial Carcinoma
- Trial name
- ST-ICI02 (NCT04892849)
- Testing
- Conventional Therapy acc. to prevailing clincal approved schemes
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cervical Cancer
Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition.
- Trial name
- NCT07121543
- Testing
- Brachytherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Cancer
Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer
This randomized clinical trial studies radiation therapy and MK-3475 in treating patients with head and neck cancer, kidney cancer, melanoma, or lung cancer that has returned, has spread to other parts of the body, or cannot be…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Cancer, Recurrent Head and Neck Carcinoma, Recurrent Lung Carcinoma
- Trial name
- NCT02318771
- Testing
- Radiation Therapy (RT), MK-3475
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Cervical Cancer
Proton and Carbon Ion Radiotherapy for Cervical Cancer
The aim of this study is to evaluate the toxicity and tolerance of proton and carbon ion radiotherapy (PCRT) for cervical cancer.
- Trial name
- NCT05141825
- Testing
- proton and carbon ion radiotherapy
- Volunteers
- 16 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Cervical Cancer
Development & Validation of Utilities for Health States Relevant to Cervical Cancer Patients
Purposes of this study: 1) To define comprehensive set of descriptive health states related to treatment of cervical cancer (e.g.
- Trial name
- NCT00788216
- Testing
- Discussion & scoring of health states related to the treatment of cervical cancer
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Arrhythmias, Cardiac, Breast Cancer
LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology
This study will develop a whole-of-body markerless tracking method for measuring the motion of the tumour and surrounding organs during radiation therapy to enable real-time image guidance.
- Conditions
- Arrhythmias, Cardiac, Breast Cancer, Prostatic Cancer, Brain Cancer
- Trial name
- LEARN (NCT05184790)
- Where
- 4 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Cervical Cancer, Cervix Cancer
Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda
This phase II trial compares the effect of hypofractionated radiotherapy (HFRT) to conventional fractionated radiotherapy (CFRT) when given in combination with cisplatin and brachytherapy in patients with stage IB3, II, or III…
- Conditions
- Cervical Cancer, Cervix Cancer, Cervical Adenocarcinoma, Cervical Small Cell Carcinoma
- Trial name
- HypoRTCx-UG (NCT07276360)
- Testing
- Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin
- Where
- Uganda
- Volunteers
- 278 people
- Sponsor
- Uganda Cancer Institute
Recurrent Gynecological Cancer, Metastatic Cervical Cancer
Durvalumab, Tremelimumab + Radiotherapy in Gynecologic Cancer
This research study is evaluating the safety and effectiveness of 2 immunotherapy drugs in combination with radiation therapy as a possible treatment for recurrent or metastatic gynecologic cancer.
- Conditions
- Recurrent Gynecological Cancer, Metastatic Cervical Cancer, Metastatic Ovarian Cancer, Metastatic Vaginal Cancer
- Trial name
- NCT03277482
- Testing
- Durvalumab, Tremelimumab, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Dana-Farber Cancer Institute
Uterine Cervical Neoplasm, Endometrial Neoplasms
Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for postoperative treatment of endometrial and cervical cancer.
- Trial name
- NCT05869123
- Testing
- Online adaptive radiotherapy
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Peking Union Medical College Hospital
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy with Concurrent Chemotherapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by concurrent chemotherapy with hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239613
- Testing
- POHIM-CCRT
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cervical Cancer
Localization of Point A in Cervical Cancer
Point A, the major critical point for dose specification of intracavitary brachytherapy, is defined as the crossing of uterine artery and ureter in treatment of cervical cancer.
- Trial name
- NCT00319462
- Testing
- hemoclip
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Mackay Memorial Hospital
Cervical Cancer, Proton Therapy
Proton Therapy for Locally Advanced Cervical Cancer
The purpose of this protocol is to determine toxicity and efficacy of proton therapy in combination with standard concomitant platinum-based chemotherapy and standard image-guided adaptive brachytherapy (IGABT) in patients with…
- Conditions
- Cervical Cancer, Proton Therapy, Radiotherapy Side Effect
- Trial name
- NCT06462378
- Testing
- Proton therapy
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- University of Aarhus
Cervical Cancer by FIGO Stage 2018, Squamous Cell Carcinoma FIGO 2018 Stage IIIA, IIIB, IIIC1-IIIC2
Pembrolizumab and Lenvatinib in Patients With High Risk Locally Advanced Cervix Cancer
The goal of this clinical trial is to learn if the combination of Pembrolizumab and Lenvatinib works to treat locally advanced cervical cancer in adults that will undergo primary chemoradiation and brachytherapy.
- Conditions
- Cervical Cancer by FIGO Stage 2018, Squamous Cell Carcinoma FIGO 2018 Stage IIIA, IIIB, IIIC1-IIIC2, Adenocarcinoma or Adeno-squamous Carcinoma Stage IB3-IIIC2
- Trial name
- NCT07368985
- Testing
- pembrolizumab and lenvatinib
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Prof. Dr. Remi A. Nout
Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy
Adjuvant Moderately Hypofractionated Intensity-modulated Radiotherapy for Cervical Cancer
To investigate the safety and efficacy of moderately hypofractionated intensity-modulated radiotherapy in the treatment of postoperative cervical cancer
- Conditions
- Hypofractionated Radiotherapy, Intensity-modulated Radiotherapy, Cervical Cancers
- Trial name
- NCT07684508
- Testing
- Postoperative Radiotherapy
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Manni Huang
Radiotherapy; Complications
Hypofractionated Radiotherapy and Concurrent Cisplatin for Head and Neck Cancer
The aim of this study is to evaluate the feasibility of hypofractionated radiation therapy and concomitant chemotherapy with cisplatin for locally advanced head and neck cancer in a high volume brazilian center.
- Trial name
- HIPOCP (NCT03194061)
- Testing
- Hypofractionated Radiotherapy, Weekly cisplatin
- Volunteers
- 20 people
- Sponsor
- Barretos Cancer Hospital
Cancer of the Cervix, Conization of the Cervix
Predicting Adjuvant Post-operative Radiation Therapy in Patients With Cervical Cancer Stage IB2
A pre- operative evaluation for the presence of intermediate risk factors prior to surgery may allow for better patient counselling, modify the course of surgery or select patients to undergo primary chemo- radiation.
- Conditions
- Cancer of the Cervix, Conization of the Cervix, Radiation Therapy
- Trial name
- NCT04868097
- Testing
- cervix biopsy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Kaplan Medical Center