Clinical trials: Cervical Cerclage
Premature Birth
LATe Cerclage in High-risk Pregnancies (LATCH)
The goal of this clinical trial is to determine whether cervical cerclage reduces the risk of preterm birth in patients with a short transvaginal ultrasound (TVU) cervical length (CL) ≤25mm between 24 0/7-26 6/7 weeks.
- Trial name
- LATCH (NCT06036446)
- Testing
- Cervical cerclage, Vaginal Suppository Progesterone
- Where
- 2 sites in United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cervical Insufficiency
Relation of the Area of Cerclage With Preterm Birth
This study is planned prospectively in pregnancies who applied to Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital which is a teritiary hospital with 15.000 births anually, between January 2022 and January…
- Trial name
- NCT05220839
- Testing
- Type of cerclage procedure Mc Donald
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Preterm Birth, Twin Pregnancy
Pessary Versus Cerclage With or Without Progesterone in Twins
This study compares the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone for prevention of preterm birth in women with a twin pregnancy and a cervix ≤28 mm.
- Conditions
- Preterm Birth, Twin Pregnancy, Short Cervix
- Trial name
- PCP-Twins (NCT03863613)
- Testing
- Pessary, Cervical cerclage, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 219 people
- Sponsor
- Mỹ Đức Hospital
Preterm Birth, Premature Birth
Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB
Prevention of preterm birth (PTB) is a key factor for a positive short-term and long-term outcome of the newborn children as mortality and morbidity are inversely related to gestational age at delivery.
- Trial name
- Prometheus (NCT03418012)
- Testing
- cervical pessary, Control-Group
- Where
- 9 sites in Australia, Germany and 2 more
- Volunteers
- 310 people
- Sponsor
- Bürgerhospital Frankfurt
Cerclage, Cervical, Cervical Insufficiency
Effectiveness of Cervico-isthmic Cerclage
This study compares the rate of live births before and after cervico-isthmic cerclage in 3 hospitals in the last 10 years. The hypothesis is that cerclage significantly increases the rate of live births in women with cervical…
- Trial name
- CERCEI LB (NCT04722536)
- Testing
- Cervico-isthmic cerclage
- Where
- 3 sites in France
- Volunteers
- 45 people
- Sponsor
- Hospices Civils de Lyon
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Preterm Birth
Cerclage for Singletons With Short Cervix Without Prior Preterm Birth
Preterm birth remains the most common cause of perinatal morbidity and mortality. A short cervi- cal length on transvaginal ultrasonography has been shown to be one of the best predictors of preterm birth.
- Trial name
- NCT02716922
- Testing
- Cervical cerclage
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Preterm Delivery, Preterm Contractions
The Impact of Bryophyllum on Preterm Delivery
The purpose of this study is whether Bryophyllum is more effective and has less side effects than traditional labor inhibitors in preventing preterm delivery.
- Conditions
- Preterm Delivery, Preterm Contractions, Cervical Shortening
- Trial name
- NCT00163579
- Testing
- Bryophyllum
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cervix Uteri-Diseases
Cervical Cerclage Position Throughout the Pregnancy.
Cervical cerclage is an obstetric intervention used in women with poor obstetric histories. After recruiting the participant, Trans vaginal sonography will be used to examine cervical length and funneling.
- Trial name
- NCT03046654
- Testing
- Trans vaginal sonography, Vaginal examination, Speculum examination
- Where
- Israel
- Volunteers
- 7 people
- Sponsor
- Rambam Health Care Campus
Cervical Cerclage
N-Acetyl Cysteine After Cervical Cerclage
The aim of the study is to evaluate the effect of N-acetyl cysteine (NAC) on pregnancy outcome in women undergoing cervical cerclage for cervical insufficiency.
- Trial name
- NAC-CC (NCT00787813)
- Testing
- N-Acetyl Cysteine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mid Trimester Cervical Shortening
A Randomized Trial of Cerclage Versus 17 α-Hydroxyprogesterone Caproate for Treatment of a Short Cervix
We hypothesized that weekly intramuscular injections of 17 hydroxyprogesterone caproate(17P) will reduce the number spontaneous preterm births prior to 35 weeks gestation when compared to cerclage therapy.
- Trial name
- NCT00694967
- Testing
- McDonald cerclage placement, 17 hydroxyprogesterone caproate
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Lehigh Valley Hospital
Labor, Premature
Ultrasound-indicated Cerclage to Prevent Premature Birth in High-risk Women
Pregnant women who have a shortened cervix and have previously had a premature baby are at increased risk for having another premature baby.
- Trial name
- NCT00059683
- Testing
- cervical cerclage
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence
Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)
This study aims to determine whether or not spinal anesthesia with the local anesthetic drug, chloroprocaine, wears off faster than the local anesthetic drug, bupivacaine, and results in faster discharge from the post-anesthesia…
- Trial name
- NCT02862912
- Testing
- Chloroprocaine, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Columbia University