Clinical trials: Cervical Cytology
Cervical Cytology, PAP
Techcyte SureView Cervical Cytology System Clinical Validation Study
The clinical study is a multi-center, retrospective, blinded, matched-pair, two-arm clinical study in which one test assessment and a control assessment of liquid-based cytology (LBC) pap tests are performed and compared to a…
- Trial name
- NCT06767111
- Testing
- Digital cervical cytology slide imaging system with artificial intelligence (AI) algorithm in vitro diagnostic (IVD) device
- Where
- United States
- Volunteers
- 4,596 people, healthy volunteers welcome
- Sponsor
- Techcyte, Inc.
Parathyroid Adenoma, Hypercalcemia
Preoperational Fine Needle Aspiration of Pathological Parathyroid Gland
Identification and localization of pathological parathyroid gland before parathyroidectomy is traditionally done by a combination of two methods: ultrasound and sestamibi scan.
- Trial name
- NCT03516747
- Testing
- pre operative parathyroid hormone level measurement, pre operative parathyroid cytology, parathyroid hormone level measurement
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Precancerous Cervical Lesion
Role of Methylation Test Triage in HPV Positive Women
The pathological results were used as the gold standard in this study and the investigators analyze the diagnostic value of six gene methylation status (ASTN1 DLX1, ITGA4, RXFP3, SOX17, ZNF671) in triaging high-risk human…
- Trial name
- MTTRIHPW (NCT06366516)
- Testing
- Methylation Test
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Endometrial Cancer, DNA Methylation
Cervical Cytology DNA Methylation for Endometrial Cancer Screening
This study intends to conduct the "Real-world Study on Cervical Cytology Methylation Testing for Endometrial Cancer Screening" project through a multi-center real-world research approach.
- Conditions
- Endometrial Cancer, DNA Methylation, Cytology, Cancer Screening
- Trial name
- NCT07874529
- Testing
- CDO1 and CELF4 gene methylation
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Lei Li
Esophageal Neoplasms, Stomach Neoplasms
Early Detection of Esophageal Cancer
Esophageal cancer is a common malignancy with a very poor prognosis. The principal reason for its poor prognosis is that most tumors are asymptomatic and go undetected until they have spread beyond the esophageal wall and are…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Endoscopy, Gastrointestinal, Digestive System Endoscopic Surgical Procedures
- Trial name
- NCT00341523
- Where
- China
- Volunteers
- 6,864 people
- Sponsor
- National Cancer Institute (NCI)
Abnormal Cytology
Oncogenous HPV DNA Integration (Intégration De l'ADN Des HPV Oncogènes)
High-risk human papillomavirus (HR-HPV) are involved in cervical cancer development. Integration of HR-HPV DNA in cellular genomes is considered as a major event in the cervical cancer development.
- Trial name
- IDAHO (NCT02864121)
- Testing
- all patients included in IDAHO study
- Where
- France
- Volunteers
- 407 people
- Sponsor
- CHU de Reims
Cervical Dysplasia
A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women
Based on the high incidence of cervical cancer and high grade dysplasia and increased progression and incomplete treatment of CIN2 and 3 in South Africa, we propose to study the effect of cryotherapy among HIV-positive women…
- Trial name
- NCT02250716
- Testing
- cryotherapy
- Where
- South Africa
- Volunteers
- 480 people
- Sponsor
- University of Witwatersrand, South Africa
Cervical Intraepithelial Neoplasia, Human Papillomavirus
A Comparison Study of Two Community Outreach-Based Approaches to Increase Participation of Women Living in the Mississippi Delta in Cervical Cancer Screening
Background: The Mississippi Delta (which includes the counties along the Mississippi River) is one of the poorest areas in the United States.
- Trial name
- NCT01058148
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute (NCI)
Human Papillomavirus
Psychosocial Effect of HPV Positivity
The use of HPV testing in cervical screening has raised concerns about the effect of a positive HPV result on women's psychological well being. This is a nested psychosocial study of the COCY trial (IRB No.
- Trial name
- NCT01459289
- Testing
- leaflet, counseling and leaflet
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
ASC-US, ASC-H
Phase II Study of Treatment for HPV16+ ASC-US, ASC-H and LSIL
To evaluate the safety and tolerability of the dual IM pNGVL4a Sig/E7(detox)/HSP70 DNA and single IM TA-CIN immunization regimen To evaluate the efficacy of dual IM pNGVL4a-Sig/E7(detox)/HSP70 DNA and single IM TA-CIN…
- Conditions
- ASC-US, ASC-H, LSIL
- Trial name
- PVX2 (NCT03911076)
- Testing
- PVX-2
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- PapiVax Biotech, Inc.
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
Cervical Carcinoma, Cervical Dysplasia
Cervical Cytology - Do SMS Reminders Increase Participation in the Cervical Screening Programme?
This study will pilot production and evaluate the use of reminder information in women invited for cervical screening for the first time within the GGC eligible population for cervical screening.
- Trial name
- NCT03975127
- Testing
- SMS text
- Volunteers
- 50,000 people
- Sponsor
- NHS Greater Glasgow and Clyde
Cervical Cancer, Cervical Intraepithelial Neoplasia
DNA Methylation Testing for the Screening of Uterine Cervical Lesion
In our published work, host DNA methylation testing has been proved to be sensitive and specific to cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+).
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, DNA Methylation, High-risk Human Papillomavirus
- Trial name
- NCT04646954
- Testing
- Host DNA methylation testing, Cervical cytology and/or high-risk human papillomavirus assays
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Lei Li
Cervical Intraepithelial Neoplasia (CIN)
Trial23 - A Method Study on Cervical Screening in Women Offered HPV-vaccination as Girls
In Denmark, the first birth cohorts of women offered HPV-vaccination as girls are entering the cervical screening program. These women are expected to be better protected against cervical cancer.
- Trial name
- NCT03049553
- Testing
- Cobas HPV-DNA test
- Where
- Denmark
- Volunteers
- 7,000 people
- Sponsor
- University of Copenhagen
Cancer of the Cervix, Cervical Intraepithelial Neoplasia
Compass - Randomised Controlled Trial of Primary HPV Testing for Cervical Screening in Australia
Compass is a randomised controlled trial of primary HPV testing for cervical cancer screening in Australia. A pilot study involving 5,000 women was carried out in 2013-2014.
- Trial name
- Compass (NCT02328872)
- Testing
- Molecular testing for HPV, Liquid Based Cytology
- Where
- Australia
- Volunteers
- 76,181 people, healthy volunteers welcome
- Sponsor
- VCS Foundation
Esophageal Squamous Cell Carcinoma, Esophageal Cancer
Esophageal cAncer Screening Trial
This multicenter study aims to include 15000 participants undergoing screening upper gastrointestinal endoscopy and establish a risk prediction model for esophageal squamous cell carcinoma and esophagogastric junctional (EGJ)…
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- EAST (NCT04609813)
- Testing
- Sponge cytological test
- Where
- China
- Volunteers
- 14,597 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
ASC-US, Human Papilloma Virus
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis.
- Trial name
- NCT03903952
- Testing
- Vitamin B12 and folate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Cervical Cancer Screening
Comparison of the Hologic Genius Digital Diagnostics System With the Liquid-based Cytology (LBC) Manual Microscopy
Quality assurance of the laboratory examinations. Prospective non-interventional study with ThinPrep slides collected during the German Co-Screening Program and routinely sent to the lab to prospectively evaluate the clinical…
- Trial name
- NCT04965857
- Testing
- Hologic's Genius Digital Diagnostics System
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- Hologic Deutschland GmbH
Diagnoses Disease, Screening
Strategies for Endocervical Canal Investigation in Women With Abnormal Screening Cytology and Negative Colposcopy
cervical cancer is the fourth most frequent cancer in women worldwide and in Brazil, it occupies the third position for the triennium 2020/2022, with a high mortality rate and maintained in the last 10 years.
- Conditions
- Diagnoses Disease, Screening, HSIL of Cervix, Cervical Cancer
- Trial name
- NCT05120167
- Testing
- Endocervical liquid-base cytology, Endocervical cell block, Endocervical curettage
- Where
- 4 sites in Brazil
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Cirbia Silva Campos Teixeira
Oral Precancer, Oral Cancer
Evaluation of Two Non-Invasive Methods, High-Resolution Microendoscopy and Liquid-Based Cytology, for Detection of Oral Precancer
Cancers of the oral cavity (lip, oral tongue, gingivae, floor of mouth, hard palate, and other mouth tissues including buccal mucosa) are amongst the most common worldwide, with an estimated annual burden of over 300,000 incident…
- Conditions
- Oral Precancer, Oral Cancer, Oral Cancer Screening
- Trial name
- NCT07260344
- Testing
- High-resolution microendoscopy of visible oral precancerous lesions, Standard of care
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Anil Chaturvedi