Clinical trials: Cervical Degenerative Disc Disease
Degenerative Disc Disease, Craniocervical Injuries
Posterior Cervical Fixation Study
The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported…
- Conditions
- Degenerative Disc Disease, Craniocervical Injuries, Cervical Radiculopathy, Cervical Disc Disease
- Trial name
- NCT04770571
- Testing
- observational study
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- NuVasive
Degenerative Disc Disease, Degenerative Spondylolisthesis
Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion
The aim of this study is to evaluate the effectiveness and safety of Natural Matrix Protein™ (NMP™) fibers when used in cervical or lumbar interbody fusion in patients with degenerative disc disease (DDD), spinal stenosis…
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT06000319
- Testing
- Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Induce Biologics USA Inc.
Cervical Disc Degeneration
Real World Data Collection and Analysis on the Anterior Cervical Spine Surgery
This observational study aims to evaluate the efficacy and safety of anterior cervical spine surgery in patients with cervical degenerative disc disease
- Trial name
- ACCSS (NCT05602714)
- Testing
- Collection Data
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Degenerative Disc Disease, Disc Herniation
Adjacent Level Anterior Cervical Fusion: SeaSpine Shoreline Versus Removal of Previously Implanted Plate and Replating
The purpose of this study is to evaluate the efficacy of SeaSpine Shoreline device in surgery of the cervical spine.
- Trial name
- NCT06415136
- Testing
- SeaSpine Shoreline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Research Source
Cervical Degenerative Disc Disorder
Post-Approval Study Protocol for the Simplify Cervical Artificial Disc
This study is intended to demonstrate the 5-year long-term safety and efficacy of the Simplify® Cervical Artificial Disc ("Simplify Disc") in subjects enrolled in the non-randomized Simplify Disc IDE study.
- Trial name
- NCT04630626
- Testing
- Simplify Disc, ACDF
- Where
- 15 sites in United States
- Volunteers
- 145 people
- Sponsor
- NuVasive
Cervical Disc Disease, Degenerative Disc Disease
Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc
A prospective, multicenter post-market clinical follow-up study to evaluate the 10-year long-term safety and effectiveness of the Simplify Disc in subjects who were enrolled in the post approval study (NCT04630626).
- Trial name
- NCT05258435
- Testing
- NuVasive Simplify Cervical Artificial Disc
- Where
- 10 sites in United States
- Volunteers
- 131 people
- Sponsor
- NuVasive
Cervical Radiculopathy
Treatment of One and/or Two Level Cervical Degenerative Disc Disease
The objective of this study is to collect clinical and radiographic outcomes using the CONDUIT™ Interbody Cervical System with supplemental fixation using a DePuy Synthes Cervical Plating System.
- Trial name
- NCT05812092
- Testing
- CONDUIT Interbody Cervical System with DePuy Synthes Cervical Plating System
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research Source
Cervical Spondylosis, Cervical Radiculopathy
Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease
DTRAX Graft is used to relieve nerve pressure in the neck in order to provide relief for Cervical Degenerative Disc Disease. This study is being conducted to determine the effectiveness of the graft, and to find out whether or…
- Conditions
- Cervical Spondylosis, Cervical Radiculopathy, Cervical Degenerative Disc Disease
- Trial name
- NCT01616719
- Testing
- DTRAX Graft
- Where
- 2 sites in United States
- Sponsor
- Providence Medical Technology, Inc.
Cervical Disc Degeneration, Cervical Stenosis
In-house Produced PMMA- Versus PEEK-cages
Subsidence of cervical cages is a common problem. For the study, a new polyacrylmethacrylate cage was designed and prospectively implanted in patients with a mono- or bilevel cervical pathology.
- Trial name
- Palcage (NCT01607775)
- Testing
- Implantation of a PEEK-cage, PMMA-cage
- Volunteers
- 88 people
- Sponsor
- Universitätsmedizin Mannheim
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Cervicobrachial Neuralgia, Cervical Discopathy
GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study
This is a prospective clinical study to assess the performance of the prosthesis according to a composite success criterion. The clinical and functional results and the patient's quality of life up to 24 months of follow-up will…
- Trial name
- NCT01518582
- Testing
- Cervical arthroplasty surgery with Granvia-C
- Where
- 3 sites in Belgium, France
- Volunteers
- 70 people
- Sponsor
- Medicrea International
Degenerative Disc Disease
LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE
The purpose of this investigation is to establish the safety and effectiveness of the LDR Spine Mobi-C® Cervical Disc Prosthesis which is an anterior cervical interbody mechanical device.
- Trial name
- NCT00389597
- Testing
- Cervical Artificial Disc
- Where
- 24 sites in United States
- Volunteers
- 599 people
- Sponsor
- LDR Spine USA
Cervical Degenerative Disc Disease
Post Market Data Collection Protocol to Evaluate the Performance of the Synergy Disc
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT05880823
- Testing
- Synergy cervical disc system
- Where
- Germany
- Sponsor
- Synergy Spine Solutions
Adjacent Segment Disease, Cervical Myelopathy
Adjacent Segment Disease After Anterior Cervical Decompression Surgery
Radiculopathy and/or myelopathy due to cervical degenerative disc disease are increasingly common pathologies in our ageing population. Both can be treated non-surgically or surgically.
- Conditions
- Adjacent Segment Disease, Cervical Myelopathy, Cervical Radiculopathy, Degenerative Disc Disease
- Trial name
- ASDafterACDF (NCT04320043)
- Testing
- Anterior cervical decompression
- Where
- Netherlands
- Volunteers
- 673 people
- Sponsor
- Zuyderland Medisch Centrum
Degenerative Disc Disease, Spondylolisthesis
Quintex® Follow-up After One Year Minimum
Prospective study, not randomised, non-interventional, monocentric, investigating an intended patient cohort of 60 patients already operated on the cervical spine due to degenerative disc disease of the cervical spine down to the…
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Trauma, Spinal Stenosis
- Trial name
- Quintex (NCT04489394)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Cervical Degenerative Disc Disease
Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease
The purpose of the study is to evaluate the performance of the Discover cervical Artificial disc in the treatment of degenerative disc disease in one level of the cervical spine.
- Trial name
- NCT00700739
- Testing
- DISCOVER™ Artificial Cervical Disc, ACDF
- Where
- 8 sites in Australia, Germany and 5 more
- Volunteers
- 60 people
- Sponsor
- DePuy International
Degenerative Disc Disease
Cervical Interbody Fusion Device Patient Registry
The registry has been designed as a prospective, observational program for patients undergoing anterior cervical discectomy and fusion (ACDF) procedures treated with TIDAL cervical interbody fusion device.
- Trial name
- NCT05114356
- Testing
- TIDAL Cervical Interbody Fusion implant
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Restor3D
Low Back Pain, Neck Pain
Applying Artificial Intelligence in Developing Personalized and Sustainable Healthcare for Spinal Disorders
The primary objective is to use machine learning methods on large survey and health register data to identify participants with different treatment trajectories and health outcomes after surgical and/or conservative treatment for…
- Conditions
- Low Back Pain, Neck Pain, Disc Herniation, Disc Degeneration
- Trial name
- AID-Spine (NCT05745129)
- Where
- Norway
- Volunteers
- 165,000 people
- Sponsor
- Oslo Metropolitan University
Degenerative Disc Disease, Herniated Disc
Bone Graft Materials Observational Registry
A multi-center, prospective, observational patient registry to collect information on the clinical outcomes and "real world" use of approved and commercially available bone graft substitutes, autograft and allograft.
- Conditions
- Degenerative Disc Disease, Herniated Disc, Spinal Stenosis, Spondylolithesis
- Trial name
- APPROACH-001 (NCT00974623)
- Testing
- Bone graft substitute, autograft or allograft
- Where
- 14 sites in United States, Hungary and 1 more
- Volunteers
- 329 people
- Sponsor
- Baxter Healthcare Corporation