Clinical trials: Cervical Disk Disease
Cervical Lordosis Rehabilitation
Does Improvement Towards a Normal Cervical Sagittal Configuration Aid in the Management of Lumbosacral Radiculopathy
A randomized controlled study with six months follow-up will be conducted to investigate the effects of sagittal head posture correction on 3D spinal posture parameters, back and leg pain, disability, and S1 nerve root function…
- Trial name
- NCT05553002
- Testing
- Deneroll cervical extension traction, Traditional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Intervertebral Disc Degeneration
Adjacent Segment Mechanics in Cervical Arthrodesis Patients
This study aims to determine to what extent patient-specific factors, iatrogenic factors, and biomechanical factors influence cervical spine mechanics after single-level and two-level arthrodesis.
- Trial name
- NCT03028402
- Testing
- C5-C6 arthrodesis
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Temporomandibular Disorders (TMDs), Temporo-mandibular Dysfunction
Effects of Orofascial Myofunctional Therapy and Cervical Stabilization Exercises on Temporomandibular Dysfunction
Temporomandibular disorders (TMDs) are among the most common musculoskeletal conditions affecting the craniofacial region and are characterized by pain, joint sounds, restricted movement, and functional limitations.
- Conditions
- Temporomandibular Disorders (TMDs), Temporo-mandibular Dysfunction, Disc Displacement
- Trial name
- OMT (NCT07828587)
- Testing
- orofacial myofunctional therapy, cervical stabilization exercises
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Degenerative Disc Disease
Investigation of DEXA-C Anterior Cervical Interbody System
FDA Cleared interbody product for the cervical spine, designed to match a patients DEXA scan for increase in fusion rate.
- Trial name
- DEXA-C (NCT05883436)
- Testing
- DEXA-C Cervical Interbody System
- Where
- 4 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Aurora Spine and Pain
Diskectomy, Intervertebral Disk Displacement
Cervical Spine; Movement Before and After Anterior Cervical Discectomy, With or Without a Cervical Disc Prosthesis
The purpose of this study is to find out if use of a cervical disc prosthesis in the treatment of a cervical disc herniation preserves or restores normal mobility and movement in the cervical spine.
- Trial name
- NCT00868335
- Testing
- Activ C disc prosthesis, Anterior cervical discectomy
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Cervical Disc Disease
Clinical and Radiological Outcomes of Anterior Cervical Discectomy and Fusion by Zero Profile Anchored Cage for Cervical Degenerative Disc Disease
The incidence of degenerative cervical conditions is increasing with the aging population, and it is well-recognized as a primary cause of myelopathy, radiculopathy, and disc herniation.
- Trial name
- NCT07743801
- Testing
- Anchored cage for CDD
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Cervical Disc Degenerative Disorder
Evaluating The Safety and Effectiveness of The NeoDisc™ Versus ACDF in Subjects With Single-Level Cervical Disc Disease
The purpose of the study is to evaluate the safety and effectiveness of the NeoDisc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical disc disease, by demonstrating non-inferior…
- Trial name
- NeoDisc™ (NCT00478088)
- Testing
- NeoDisc, Instrumented Anterior Cervical Discectomy and Fusion (ACDF)
- Where
- 22 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- NuVasive
Emergencies
Mesotherapy Versus Systemic Therapy in Treating Neck Pain Related to Herniated Disc
Introduction: Neck pain is a global public health concern, that ranked 4th highest health condition in terms of disability as measured by years lived with disability.
- Trial name
- NCT04519333
- Testing
- drug(intradermal injection)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ataturk University
Cervical Spine Degenerative Disc Disease, Fusion of Spine, Cervical Region
Comparison of Outcomes Between Early Physical Therapy Intervention and Usual Care Following Anterior Cervical Fusion Surgery
Background: Early physical therapy (PT) intervention with emphasis on spinal stabilization has been shown to benefit individuals undergoing lumbar spinal surgery.
- Trial name
- ACF (NCT01519115)
- Testing
- early physical therapy intervention, usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Texas Woman's University
Degenerative Disc Disease
INFUSE® Bone Graft/ PEEK Interbody Spacer/ Anterior Cervical Plate Pivotal Clinical Trial
The purpose of this study is to evaluate the safety and effectiveness of the investigational implant (INFUSE® Bone Graft/PEEK Interbody Spacer/Anterior Cervical Plate) as a method of facilitating spinal fusion at a single level…
- Trial name
- ACDF (NCT00485173)
- Testing
- INFUSE® Bone Graft/PEEK Spacer/Anterior Cervical Plate
- Where
- 16 sites in United States
- Volunteers
- 224 people
- Sponsor
- Medtronic Spinal and Biologics
Cervical Fusion, Cervical Disc Degeneration
Allogeinic Bone Paste
This is a prospective, single arm, single center clinical study to evaluate efficacy and safety of a Supercritical CO2 viral-inactivated allogenic bone paste in cervical interbody fusion.
- Conditions
- Cervical Fusion, Cervical Disc Degeneration, Spinal Fusion
- Trial name
- NCT04605120
- Testing
- Cervical fusion
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Biobank
Lumbar Disk Herniation, Lumbar Spinal Stenosis
Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age Patient
To determine the high risk factors affecting accelerated recovery after spinal fusion surgery in advanced age patient.
- Conditions
- Lumbar Disk Herniation, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Cervical Spondylotic Myelopathy
- Trial name
- NCT06591442
- Testing
- This is an observational study
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Contained Cervical Disc Herniation
Is Treatment of the Intervertebral Disc More Effective at Short-term Than the Nerve Root in Patients With a Neck Hernia?
Pain management in a neck hernia relies initially on rest, physiotherapy, and/or oral medications. Once these treatments have failed, different alternative procedures can be applied to relief pain.
- Trial name
- NCT01797172
- Testing
- Percutaneous Cervical Nucleoplasty, Pulsed Radio Frequency
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Willy Halim
Degenerative Disc Disease
Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF)
The purpose of this study is to utilize Trinity Evolution in conjunction with an interbody spacer and supplemental anterior fixation of the surgeon's choice and to follow the patients to measure the clinical outcomes and rate of…
- Trial name
- NCT00951938
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Orthofix Inc.
Cervical Degenerative Disc Disease
Total Disc Replacement Versus Anterior Cervical Decompression and Fusion
Background : Cervical degenerative disc disease is frequent and the consequence of aging. Degeneration may lead to disc herniation.
- Trial name
- CERVIDISC (NCT02417272)
- Testing
- Surgical treatment of cervical degenerative disc disease (CP ESP®), Surgical treatment of cervical degenerative disc disease (Axelle®)
- Where
- 3 sites in France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Bordeaux
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Cervical Spondylosis, Degenerative Intervertebral Discs
An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix
The purpose of this post-market study is to collect data on ViviGen and how its use affects fusion rates in the cervical spine when used as additional grafting material to fill the cervical spacer.
- Conditions
- Cervical Spondylosis, Degenerative Intervertebral Discs, Herniated Disc
- Trial name
- NCT02814825
- Testing
- ViviGen
- Volunteers
- 100 people
- Sponsor
- DePuy Spine
Cervical Radiculopathy, Cervical Disc Herniation
Clinical Outcomes of Magnesium Sulfate in Cervical Interlaminar Epidural Steroid Injection
This single-center observational comparative cohort study evaluates clinical outcomes following two cervical interlaminar epidural steroid injection protocols used in routine care for chronic cervical radicular pain due to…
- Trial name
- NCT07788820
- Testing
- Magnesium Sulfate, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Marmara University
Low Back Pain, Neck Pain
The Effect of Integrated CAM Treatment in Hospitalized Patients
This study investigates the effect of hospital-based intensive non-surgical treatment in musculoskeletal patients admitted to an integrated hospital that offers both complementary and alternative medicine (CAM) and conventional…
- Conditions
- Low Back Pain, Neck Pain, Knee Pain, Shoulder Pain
- Trial name
- NCT02257723
- Testing
- Herbal medicine, Acupuncture, Pharmacopuncture
- Where
- South Korea
- Volunteers
- 100,000 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Temporomandibular Disorder (TMD), Cervical Vertebrae
Morphometric and Morphological Analysis of Cervical Vertebrae in Disc Displacement
Temporomandibular disorders (TMDs) are multifactorial clinical conditions affecting the masticatory muscles, the temporomandibular joint (TMJ), and the surrounding structures.
- Conditions
- Temporomandibular Disorder (TMD), Cervical Vertebrae, Disc Displacement, Dentistry
- Trial name
- TMJ (NCT07429435)
- Testing
- cephalometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Kutahya Health Sciences University