Clinical trials: Cervical Fusion
Disc Degeneration;Cervical
The NanoStrand Clinical Study
A prospective, multi-center, randomized, self-controlled, single-blinded, clinical study evaluating the NanoMetalene implant as compared to the PEEK and allograft implants in ACDF for the treatment of cervical degenerative disc…
- Trial name
- NCT03871400
- Testing
- Anterior cervical discectomy and fusion
- Where
- 11 sites in United States
- Volunteers
- 18 people
- Sponsor
- SeaSpine, Inc.
Cervical Cancer, Uterine Cancer
Efficacy of the Standard Treatment and Fusion Ontogenetic Surgery for Gynecologic Cancers
The purpose of this study is to compare standard treatment and fusion ontogenetic surgery (total mesometrial resection, laterally extended endopelvic resection, peritoneal mesometrial resection) for gynecologic cancer in order to…
- Trial name
- FUSIONIV (NCT02986568)
- Testing
- Cervical cancer, Uterine cancer, Cervical cancer, pelvic sidewall invasion
- Where
- South Korea
- Volunteers
- 380 people
- Sponsor
- Seoul National University Hospital
RET-altered Non Small Cell Lung Cancer, Medullary Thyroid Cancer
Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667)…
- Conditions
- RET-altered Non Small Cell Lung Cancer, Medullary Thyroid Cancer, RET-altered Papillary Thyroid Cancer, RET-altered Colon Cancer
- Trial name
- ARROW (NCT03037385)
- Testing
- pralsetinib (BLU-667)
- Where
- 71 sites in United States, Belgium and 11 more
- Volunteers
- 590 people
- Sponsor
- Hoffmann-La Roche
Intervertebral Disc Degeneration
Comparison of nanOss Cervical IBF System to C-Plus PEEK IBF Device With Autograft
This is a post-market, prospective, randomized clinical investigation to evaluate the performance of the nanOss Cervical Interbody Fusion (IBF) device with nanOss Bioactive Bone Void Filler for the treatment of cervical disc…
- Trial name
- NCT02586116
- Testing
- nanOss, C-Plus
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- RTI Surgical
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion
The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical vertebral levels between C3-C4 to C7-T1.
- Conditions
- Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT01106417
- Testing
- NeoFuse, MasterGraft Granules
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Mesoblast, Ltd.
Cervical Stenosis
Outpatient Posterior Cervical Fusion: Outcomes of the First 100 Consecutive Cases
Observational study regarding outcomes, complications, and patient acceptance for 100 consecutive patients undergoing outpatient posterior cervical decompression, instrumentation and fusion.
- Trial name
- NCT07242989
- Testing
- Enhanced recovery after surgery protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NeuroSpine Center of Wisconsin
Neck Pain, Cervical Spondylosis
Predictors of Axial Pain Improvement After Anterior Cervical Discectomy and Fusion
Neck pain is a common, multifactorial condition. In the case of degenerative cervical spinal disease, it can result from changes in the intervertebral discs, muscles, intervertebral joints, or sagittal imbalance.
- Conditions
- Neck Pain, Cervical Spondylosis, Cervical Disc Disease
- Trial name
- NCT06601634
- Where
- 2 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Anterior Cervical Discectomy and Fusion (ACDF)
Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery
This study will help the investigators learn more about the best way to give anesthesia for these kinds of surgery. The investigators will be using 2 different groups of medications that is commonly used in ACDF surgery, one…
- Trial name
- NCT03643796
- Testing
- Remifentanil, Ketamine, Dexmedetomidine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Atlantoaxial Dislocation, Chiari Malformation
Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base Depression
The research background of this study is that Chiari malformation (CM) is a congenital malformation in the foramen magnum region, often associated with syringomyelia, basilar depression, odontoid dislocation and other…
- Conditions
- Atlantoaxial Dislocation, Chiari Malformation, Basilar Invagination
- Trial name
- NCT05754554
- Testing
- Atlas occipital decompression lateral joint release combined with occipital-neck fusion, Simple FMD with Outer Dural Delamination
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Southern Medical University, China
Spinal Fusion, Cervical Spine Degenerative Disease
Early Postoperative Home Exercise Program After Cervical Spine Surgery
The overall objective of this two-group randomized controlled trial is to gather preliminary evidence on the efficacy and safety of early postoperative exercise for improving disability, pain, and general physical health in…
- Trial name
- NCT02720172
- Testing
- Early Home Exercise Program, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Cervical Disc Degeneration
Comparison of Rigid and Non-Rigid Interbody Fusion Device for Cervical Degenerative Disc Disease in Adults
Rigid interbody fusion device in bulk configuration has been widely used in anterior cervical discectomy and fusion (ACDF) surgery.
- Trial name
- NCT04550923
- Testing
- Z-Brace interbody fusion device, PEEK interbody fusion device
- Where
- 13 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Cervical Arthrodesis
rhBMP-2 in Cervical Arthrodesis
This prospective study will investigate the use of recombinant human bone morphogenetic protein (rhBMP-2) in the current surgical standard of care for cervical spine pathology.
- Trial name
- NCT02178605
- Testing
- Cervical arthrodesis with rhBMP-2
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Virginia Spine Institute
Clinical Radiculopathy, Myelopathy Due to a Cervical Disk Disease
Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level
The aim of the study is to evaluate the impact of the cervical disk surgery on the deterioration of the adjacent levels. The investigators compare the radiological deterioration of adjacent levels, at 3 years, in both situation…
- Trial name
- PROCERV (NCT00554528)
- Testing
- cervical disc prosthesis with a mobile insert named Mobi-C, arthrodesis - cervical disk surgery
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Degenerative Disc Disease in Cervical Spine, Stenosis Cervical Spine
PMCF Study Fortilink-SC
This study is setup to be able to gather information on the safety and performance of the Fortilink-SC Ti cage of Paradigm Spine GmbH, up to one year after the surgery.
- Trial name
- NCT07834749
- Testing
- Cervical interbody fusion surgery (standalone)
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- BAAT Medical Products B.V.
Squamous Cell Carcinoma of Head and Neck
Evaluation of Bintrafusp Alfa in Operable and Untreated Head and Neck Squamous Cell Carcinoma
This study is a prospective open label, multicenter, phase II, window-of-opportunity preoperative, single-agent trial. This study aims to evaluate the efficacy, the safety and tolerability profile of bintrafusp alfa in patients…
- Trial name
- ICING (NCT04428047)
- Testing
- bintrafusp alfa
- Where
- 8 sites in France
- Volunteers
- 7 people
- Sponsor
- UNICANCER
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Differentiated Thyroid Cancer, Pediatric Cancer
Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)
Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy.
- Conditions
- Differentiated Thyroid Cancer, Pediatric Cancer, Cancer, Cancer, Thyroid
- Trial name
- RAISE (NCT06458036)
- Testing
- Selpercatinib Monotherapy, 131I Therapy
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Cervical Disc Herniation, Cervical Degenerative Disc Disease
Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion
The purpose of this study is to determine what effect intraoperative topical steroids have on reducing swallowing difficulty following Anterior Cervical Discectomy and Fusion surgery.
- Conditions
- Cervical Disc Herniation, Cervical Degenerative Disc Disease, Cervical Spondylotic Myelopathy, Dysphagia
- Trial name
- NCT02539394
- Testing
- Methylprednisolone Acetate, Hemostatic Matrix Kit
- Volunteers
- 128 people
- Sponsor
- Hospital for Special Surgery, New York
Cervical Spine Fusion
Single Level Anterior Cervical Corpectomy Without Posterior Stabilization
evaluate and assess short term outcome of treating degenerative and non-degenerative cervical conditions with single level anterior cervical corpectomy without posterior fusion
- Trial name
- NCT05479864
- Testing
- anterior cervical corpectomy and fusion
- Volunteers
- 20 people
- Sponsor
- Assiut University
Radiculopathy
Cervical Foraminal Stenosis and Radiculopathy - ACDF Versus Minimal Invasive Posterior Cervical Foraminotomy.
A prospective randomized clinical trial. Cervical spondylotic foraminal stenosis with radiculopahty. Comparison results between 2 treatment options: ACDF and minimal invasive posterior cervical foraminiotomy.
- Trial name
- NCT02350621
- Testing
- ACDF, minimal invasive Posterior Cervical Foraminotomy
- Volunteers
- 80 people
- Sponsor
- Stockholm Spine Center AB