Clinical trials: Cervical Intraepithelial Neoplasia (CIN)
Cervix; Intraepithelial Neoplasia
Depth of Necrosis in Normal Cervical Epithelium After 85% Trichloroacetic Acid (TCA) Application
Early detection and treatment of precancerous lesions are the pillars of cervical cancer prevention. Cervical Intraepithelial Neoplasia (CIN) is a precancerous lesion that histologically can be found in one of three stages of…
- Trial name
- NCT04911075
- Testing
- 85% TCA Solution
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Human Papillomavirus-Related Malignant Neoplasm
Study of Targeted Therapy Using Transcription Activator-like Effector Nucleases in Cervical Precancerous Lesions
This is an single arm clinical study of the safety and efficacy of T512 to possibly treat cervical intraepithelial neoplasia(CIN).
- Trial name
- NCT03226470
- Testing
- T512
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Cervical Intraepithelial Neoplasia, Cervical Cancer
Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent（Type 16/18 ）Vaccine
This is a Phase III clinical trial of the novel recombinant HPV 16/18 bivalent vaccine manufactured by Xiamen Innovax Biotech CO., LTD.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT01735006
- Testing
- HPV Vaccine, HEV vaccine
- Where
- China
- Volunteers
- 7,372 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Uterine Cervical Dysplasia
LLETZ With Videocolposcopy Versus LLETZ With Binocular Colposcopy
To assess the benefits of performing large Loop excision of the transformation Zone (LLETZ) using videocolposcopy compared to binocular colposcopy.
- Trial name
- NCT04326049
- Testing
- LLETZ with videocolposcope, LLETZ with binocular colposcope
- Where
- Germany
- Volunteers
- 227 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Intraepithelial Neoplasia
A Clinical Trial of PepCan to Two Therapy Arms for Treating Cervical High-Grade Squamous Intraepithelial Lesions
This is a Phase II study to evaluate the efficacy and safety of a human papilloma virus (HPV) therapeutic vaccine called PepCan (HPV 16 E6 peptides combined with Candida skin testing reagent called Candin®) in adult females over…
- Trial name
- NCT02481414
- Testing
- PepCan, Candin®
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Arkansas
Precancerous Condition, Stage 0 Cervical Cancer
Protein Expression as a Potential Diagnostic Biomarker of Cervical Dysplasia and/or Cancer
This diagnostic trial is studying the presence of a specific protein as a potential biomarker of cervical dysplasia and/or cancer.
- Trial name
- NCT00003384
- Testing
- Cervical Papanicolaou Test, Conization, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- Gynecologic Oncology Group
Cervical Intraepithelial Neoplasia (CIN), Genital Warts
Impact of HPV Vaccination Against Cervical Lesions and Genital Warts in Colombia. an Ecological Assessment
The goal of this observational study is to assess the impact of HPV vaccination on cervical lesions and genital warts in Colombian birth cohorts.
- Conditions
- Cervical Intraepithelial Neoplasia (CIN), Genital Warts, Papillomavirus Infections, Cervical Cancers
- Trial name
- NCT06700941
- Testing
- HPV vaccine
- Where
- Colombia
- Volunteers
- 8,000,000 people
- Sponsor
- Universidad Nacional de Colombia
Cervical Intraepithelial Neoplasia
Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization
Cervical conization is done for pre-cancer disease. The procedure is performed with local anesthesia and general anesthesia. Local anesthesia is given by paracervical block, and several different local anesthetics is being used…
- Trial name
- HSBAPCB (NCT02368054)
- Testing
- Bupivacaine, Adrenaline
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- Helse Fonna
Cervical Cancer, Precancerous Condition
Fluorescence and Reflectance Spectroscopy During Colposcopy in Detecting Cervical Intraepithelial Neoplasia and Dysplasia in Healthy Participants With a History of Normal Pap Smears
RATIONALE: New diagnostic procedures such as fluorescence and reflectance spectroscopy (shining light on tissue and measuring patterns of light reflected) may improve the ability to noninvasively detect cervical intraepithelial…
- Trial name
- NCT00084903
- Testing
- Colposcopic biopsy, Light-Scattering Spectroscopy
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,070 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer
A Non-inferiority Evaluation of a Smart-phone Based Cervical Imaging Device.
When a woman has an abnormal pap smear or tests positive for a high risk strain of the HPV virus, the current standard of care includes culposcopic examination of the cervix with biopsy.
- Trial name
- NCT05388162
- Testing
- Mobile colposcope
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Cervical Intraepithelial Neoplasia
A Follow-up Extension Study to Evaluate the Persistence of Immune Response to GSK Biologicals' HPV Vaccine in Healthy Chinese Female Subjects Who Received Three Doses of the Vaccine in the HPV-058 Study
The purpose of this study is to evaluate the persistence of immune response in subjects who received the HPV-16/18 vaccine, seven to eight years after the last dose of primary vaccination in the HPV-058 study.
- Trial name
- NCT03355820
- Testing
- Blood sampling for antibody determination
- Where
- China
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Efficacy of Tachosil® for Prevention of Hemorrhage After Loop Electrosurgical Excisional Procedure (LEEP)
This study is aimed at identifying the efficacy of Tachosil® for prevention of hemorrhage in patients with cervical intraepithelial neoplasia or cervical cancer after undergoing a loop electrosurgical excisional procedure (LEEP).
- Trial name
- TACO (NCT02629510)
- Testing
- Tachosil
- Where
- South Korea
- Volunteers
- 268 people
- Sponsor
- Asan Medical Center
Cervical Cancer, Cervical Intraepithelial
Cervical Cancer Early Endpoints and Determinants
This study, conducted by the National Cancer Institute and the University of Oklahoma, will look for changes in cervix cells and other samples that may be signs of cervical disease.
- Conditions
- Cervical Cancer, Cervical Intraepithelial, Neoplasia, CIN
- Trial name
- NCT00339989
- Where
- United States
- Volunteers
- 3,013 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer, Cervical Precancer
Adherence to Preventive Care for Cervical Cancer
In the United States, the highest incidence of cervical cancer occurs in inner city urban centers, rural areas, the deep South, Appalachia and the U.S.-Mexico border.
- Conditions
- Cervical Cancer, Cervical Precancer, Adherence
- Trial name
- Adh-NYC-EP (NCT02406391)
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Brookdale University Hospital Medical Center
Uterine Cervical Dysplasia
LLETZ Under General Versus Local Anesthesia
The investigators conduct a prospective, randomized trial to assess the benefits of performing large loop excision of the transformatione zone (LLETZ) under local anesthesia and compare it to LLETZ under general anesthesia.
- Trial name
- NCT03494686
- Testing
- LLETZ under local anaesthesia, LLETZ under general anaesthesia
- Where
- Germany
- Volunteers
- 229 people
- Sponsor
- Zydolab - Institute of Cytology and Immune Cytochemistry
Cervical Dysplasia, Pain
Virtual Reality: Influence on Satisfaction, Pain, and Anxiety in Patients Undergoing Colposcopy
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the screening smear test at the gynecologist's office and…
- Conditions
- Cervical Dysplasia, Pain, Anxiety
- Trial name
- NCT04751799
- Testing
- Virtual reality headset before colposcopy, Virtual reality headset during colposcopy
- Where
- Germany
- Volunteers
- 247 people
- Sponsor
- Ruhr University of Bochum
Cervical Cancer
Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia
The goal of this clinical research study is to compare a type of imaging called high-resolution microendoscopy (HRME) for detecting abnormal tissue in the cervix to the standard of care, which is visual inspection with acetic…
- Trial name
- NCT02420665
- Testing
- Proflavine, HRME Imaging, Phone Call
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Dysplasia
A Pilot Study to Evaluate Ultrasonic Surgical Aspiration as a Treatment Modality for Cervical Dysplasia
Ultrasonic surgical aspiration of the cervix may be an effective method of treating cervical dysplasia without compromising the integrity of the cervix in reproductive age women.
- Trial name
- NCT00374114
- Testing
- cervical conization, ultrasonic surgical aspiration of the cervix
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Cervical Cancer, Cervical Dysplasia
Self-sampling for Non-attenders to Cervical Cancer Screening
The trial will evaluate whether self-sampling and human papillomavirus (HPV) testing may increase cervical cancer screening attendance among under-screened women in Czech Republic.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Human Papillomavirus Infection
- Trial name
- KOPRETINA (NCT04226313)
- Testing
- Self-sampling by Evalyn Brush, Self sampling by Evalyn Brush home or in GP´s clinic
- Where
- Czechia
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Cervical Cancer
SmartScope vs Standard Colposcope for the Evaluation of Cervical Dysplasia
This trial will compare images obtained from a mobile colposcope with those obtained using a standard of care.
- Trial name
- NCT02272075
- Testing
- Mobile OCT M3 scope
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scripps Health