Clinical trials: Cervical Lesion
Oral Premalignant Lesions as Leukoplakia and Lichen Planus, Oral Cancer
Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Aim: The current study targets linking serum and salivary dipeptidyl peptidase-4 with oral squamous cell carcinoma and comparing it with potentially malignant lesions and control to validate dipeptidyl peptidase-4 as a diagnostic…
- Trial name
- NCT06087042
- Testing
- serum and unstimulated salivary samples
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Universal Adhesive
HEMA-free Universal Adhesives for Restoring Non-carious Cervical Lesions
because of the recent introduction of universal adhesives, little information is currently available about the bond durability of universal adhesives to various substrates.
- Trial name
- NCT05497583
- Testing
- Acetone based HEMA -free universal Adhesive, Isopropanol based HEMA- free universal Adhesive
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infection, Precancerous Condition
Human Papillomavirus Vaccine Therapy in Treating Men With HIV-1 Infection
RATIONALE: Vaccines made from human papillomavirus may help the body build an effective immune response to kill HIV cells. PURPOSE: This phase II trial is studying the side effects and how well human papillomavirus vaccine…
- Trial name
- NCT00513526
- Testing
- Gardasil
- Where
- 8 sites in United States
- Volunteers
- 112 people
- Sponsor
- AIDS Malignancy Consortium
Suspicious Cervical Cancer Lesions Follow up Adherence
Key Interventions to Improve the Follow-up Adherence Post Cervical Precancerous Lesion Treatment in Ethiopia
The goal of this pragmatic randomized control trial is to evaluate the effectiveness of three interventions in improving follow-up adherence among women treated for suspicious cervical lesions in primary healthcare settings in…
- Trial name
- NCT06515301
- Testing
- Intervention 1: Structured nurse-led telephone call reminders. Intervention 2: Home-visit reminders by health extension workers. Intervention 3: Application-based automated SMS text reminders.
- Where
- Ethiopia
- Volunteers
- 466 people
- Sponsor
- Addis Ababa University
Dental Caries
Evaluation Of Clinical Performance of Self-adhering Flowable Composite vs Conventional Flowable Composite in Cervical Carious Lesions
This clinical trial will be conducted to compare the clinical performance of a new self-adhering flowable composite in restoring CLs compared to conventional flowable composite in geriatric patients over 12 months.
- Trial name
- NCT04475172
- Testing
- Self-Adhesive Flowable Composite
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypopharyngeal Neoplasms, Laryngeal Neoplasms
Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive Tract
To assess the use of the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) in transoral surgeries in patients with benign and malignant lesions of the oral cavity and laryngopharynx.
- Conditions
- Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Head and Neck Cancers
- Trial name
- NCT00721539
- Testing
- da Vinci Surgical Robot Platform, Transoral Robotic Surgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Cervical Cancer, Tobacco Use
Smoking Cessation for Cervical Cancer Survivors
The goal of this research study is to compare a program called Motivation And Problem-Solving (MAPS) to the standard treatment to help participants with a history of cervical cancer or high-grade cervical dysplasia quit smoking.
- Conditions
- Cervical Cancer, Tobacco Use, Smoking Cessation
- Trial name
- NCT02157610
- Testing
- Self-Help Materials, Nicotine Patch, REDCap
- Where
- 3 sites in United States
- Volunteers
- 202 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cervical Cancer
Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia
The overall objective of this study is to identify potential improvements for a noninvasive method of diagnosing dysplasia and neoplasia in the cervix using digital colposcopy for colposcopy for fluorescence spectroscopy.
- Trial name
- NCT00513123
- Testing
- Colposcopy
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Secondary Dental Caries
Assessment of Bioactive Bulk Fill Composite Versus High Viscosity Glass Ionomer Restorations for Carious Lesions
This trial will be conducted to compare the clinical performance between a new bioactive resin composite material and high viscosity glass ionomer for restoring occlusal carious lesions of posterior teeth in patients scheduled…
- Trial name
- NCT05332041
- Testing
- Predicta Bioactive bulk fil composite restoration
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Association of Heterotopic Gastric Mucosa of the Cervical Esophagus and Globus Sensations
Prevalence of Gastric Inlet Patches of the Cervical Esophagus.
As known from several observational and retrospective endoscopic studies the prevalence of gastric inlet patches (GIPs) of the cervical esophagus is estimated between 1-10%.
- Trial name
- NCT01056003
- Testing
- Endoscopy
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- Technical University of Munich
Cervical Cancer, Cervical Precancerous Lesions
Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India
The primary study hypothesis wasthat a two-dose human papillomavirus (HPV) vaccine regimen would offer similar immunogenicity and protection as that of a three-dose regimen to girls against persistent HPV infection and cervical…
- Trial name
- NCT00923702
- Testing
- Prophylactic quadrivalent HPV vaccine Merck (Gardasil®)
- Where
- 8 sites in India
- Volunteers
- 22,729 people, healthy volunteers welcome
- Sponsor
- Partha Basu
Endometrial Cancer, Cervical Cancer
Tachosil for the Prevention of Symptomatic Lymph Cysts
This is a randomized trial of 140 women with endometrial or cervical cancer undergoing removal of lymph tissue (lymphadenectomy).
- Trial name
- NCT01470677
- Testing
- Tachosil fibrin patch
- Where
- 2 sites in Austria, Germany
- Volunteers
- 220 people
- Sponsor
- Ruhr University of Bochum
Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site
Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial Lesions
Randomized, placebo-controlled phase 3 trial to evaluate nonavalent HPV vaccine as a secondary prevention in patients treated for human papilloma virus related high-grade squamous intraepithelial lesions.
- Conditions
- Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Penile Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Cervical Site
- Trial name
- BioHPV (NCT07431502)
- Testing
- HPV vaccine
- Volunteers
- 984 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Human Papillomavirus-Related Malignant Neoplasm
Study of Targeted Therapy Using Transcription Activator-like Effector Nucleases in Cervical Precancerous Lesions
This is an single arm clinical study of the safety and efficacy of T512 to possibly treat cervical intraepithelial neoplasia(CIN).
- Trial name
- NCT03226470
- Testing
- T512
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Cervix Cancer
Evaluation of the Diagnostic and Prognostic Value of Immunohistochemical Markers in Precancerous Lesions of the Cervix
The study aims to evaluate the expression of certain proteins and their diagnostic and prognostic value in precancerous lesions of the cervix.
- Trial name
- NCT06852157
- Testing
- Tissue, diagnostic and prognostic accuracy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cervical Intraepithelial Neoplasia
A Clinical Trial of PepCan to Two Therapy Arms for Treating Cervical High-Grade Squamous Intraepithelial Lesions
This is a Phase II study to evaluate the efficacy and safety of a human papilloma virus (HPV) therapeutic vaccine called PepCan (HPV 16 E6 peptides combined with Candida skin testing reagent called Candin®) in adult females over…
- Trial name
- NCT02481414
- Testing
- PepCan, Candin®
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Arkansas
Cervical Intraepithelial Neoplasia (CIN), Genital Warts
Impact of HPV Vaccination Against Cervical Lesions and Genital Warts in Colombia. an Ecological Assessment
The goal of this observational study is to assess the impact of HPV vaccination on cervical lesions and genital warts in Colombian birth cohorts.
- Conditions
- Cervical Intraepithelial Neoplasia (CIN), Genital Warts, Papillomavirus Infections, Cervical Cancers
- Trial name
- NCT06700941
- Testing
- HPV vaccine
- Where
- Colombia
- Volunteers
- 8,000,000 people
- Sponsor
- Universidad Nacional de Colombia
HPV Infection, CIN1
Prime-boost Vaccine Study in Women With Low-grade Cervical HPV Lesions
A Phase 1b/2 multi-centre study evaluating the safety, efficacy and immunogenicity of prime-boost vaccines ChAdOx1-HPV and MVA-HPV in women with HPV related low grade cervical lesions.
- Trial name
- NCT04607850
- Testing
- ChAdOx1-HPV, MVA-HPV
- Where
- 16 sites in Belgium, Estonia and 1 more
- Volunteers
- 108 people
- Sponsor
- Barinthus Biotherapeutics
Premalignant Lesion, Oral Cancer
Diagnostic Accuracy of Mobile Phone Imaging Compared to Conventional Clinical Examination for Oral Cancer Screening
The aim of study is to evaluate the sensitivity and specificity of using mobile phone photographs versus conventional clinical examination as a screening tool for early detection of oral cancer.
- Trial name
- NCT06060288
- Testing
- Diagnosis by mobile phone imaging
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Cancer
Polarized Reflectance Spectroscopy for Oral Lesions
In this study the investigators are conducting research to determine whether a new optical device using polarization reflectance spectroscopy can help doctors or dentists identify abnormalities in the mouth that require…
- Trial name
- PolProbe (NCT01604759)
- Testing
- Polarized Reflectance Spectroscopy System
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- British Columbia Cancer Agency