Clinical trials: Cervical Lesion
Cervical Lesion
Clinical Evaluation of Bulk-fill Alkasite Restoration Versus Resin Modified Glass Ionomer in Adult With Class V Carious
Cention N will have the same clinical performance as resin-modified glass ionomer in cervical carious lesions. Evaluation of restorations will be done at baseline, six months, and one year according (USPHS) criteria.
- Trial name
- NCT04716517
- Testing
- Alkasite bioactive restorative material., Resin Modified Glass Ionomer
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Clinical Performance Using Modified USPHS Criteria
Bioactive Restorative vs GIC Modified Glass Ionomer in Restoration of Cervical Lesions: Randomized Controlled Trial
Bioactive restorative materials are relatively new in dentistry. Activa BioACTIVE (Pulpdent Corporation, Watertown, MA) dual cured material is the first dental restoratives with a bioactive resin matrix, shock-absorbing resin…
- Trial name
- ActivaPresto (NCT04363996)
- Testing
- New Bioactive Restorative Material
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
High-grade Squamous Intraepithelial Lesions of the Cervix Associated With Human Papillomavirus (HPV) Type 16 and/or HPV Type 18 Infection
Evaluation of the Safety, Tolerability, Immunogenicity and Preliminary Efficacy of BBM-C101 Injection in Patients With Cervical High-Grade Squamous Intraepithelial Lesion(HSIL)
The goal of this study is to learn about the safety, tolerability, immunogenicity and preliminary efficacy of BBM-C101 injection in patients with High-Grade Squamous Intraepithelial Lesion of the cervix.
- Trial name
- NCT07668960
- Testing
- BBM-C101
- Where
- 4 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mianyi Biopharmaceutical Co., Ltd.
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Barrett Esophagus
Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch
Inlet patch is a congenital condition of the upper oesophagus, consisting of stomach lining that is in the wrong place. It affects 5% of the population.
- Trial name
- NCT03471052
- Testing
- Radiofrequency ablation (RFA)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Non-Carious Cervical Lesions (NCCLs), Dentin Hypersensitivity
Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study
The aim of this split-mouth clinical study is to compare the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity in patients with non-carious cervical…
- Trial name
- NCCL-DH (NCT07648147)
- Testing
- D Blue Diode Laser, ProSylc Bioactive Glass Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HPV, HIV Infections
Gut and Vaginal Microbiota Profile Study for HIV Women
Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions.
- Conditions
- HPV, HIV Infections, Vaginal Microbiota
- Trial name
- NCT05996016
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Musculoskeletal Diseases
Sacroiliac Orthopedic Blocking and Cervical Spine Function
This study seeks to determine if the correction of a sacroiliac lesion can produce a functional change in cervical spine. Reduction of a sacroiliac joint lesion may alter cervical spine function.
- Trial name
- NCT00523822
- Testing
- Spinal Manipulative Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Cervical Dysplasia, Pain
Virtual Reality: Influence on Satisfaction, Pain, and Anxiety in Patients Undergoing Colposcopy
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the screening smear test at the gynecologist's office and…
- Conditions
- Cervical Dysplasia, Pain, Anxiety
- Trial name
- NCT04751799
- Testing
- Virtual reality headset before colposcopy, Virtual reality headset during colposcopy
- Where
- Germany
- Volunteers
- 247 people
- Sponsor
- Ruhr University of Bochum
Esophageal Cancer, Squamous Cell
Diagnostic Accuracy of Endocytoscopy for Superficial Esophageal Neoplasia
In recent years, endocytoscopy (EC) has undergone rapid development as an advanced endoscopic technique. Characterized by real-time histological imaging and detection capabilities, EC enables visualization of living cells in the…
- Trial name
- NCT06984055
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Changhai Hospital
Precancerous Conditions
Phase I/II Study of Chemoprevention With EGFR and COX-2 Inhibitor
Evaluate effect on cells and patient response to study medications, assess side effects of these medications, and evaluate chemicals in cells that may tell how the drug works, before, and after receiving the study medications.
- Trial name
- NCT00314262
- Testing
- Erlotinib & Celecoxib
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Skin Cancer, Mucosal Neoplasm of Oral Cavity
Retreatment With Intratumoral Diffusing Alpha Radiation Emitters
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for superficial cutaneous, mucosal or soft tissue neoplasia
- Conditions
- Skin Cancer, Mucosal Neoplasm of Oral Cavity, Soft Tissue Neoplasm
- Trial name
- NCT04540588
- Testing
- Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Alpha Tau Medical LTD.
Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma
(89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma
The goal of this phase I clinical trial is to evaluate the usefulness of an imaging test (zirconium Zr89 panitumumab [89Zr panitumumab]) with positron emission tomography (PET)/computed tomography (CT) for diagnosing the spread…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Squamous Cell Carcinoma, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Trial name
- NCT05747625
- Testing
- Panitumumab, Zirconium Zr 89 Panitumumab, Positron Emission Tomography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Eben Rosenthal
Non-carious Cervical Lesion
Prevalence of Non-Carious Cervical Lesions in Patient With Gingival Recession and Associated Risk Factors
The study aims at determining the prevalence of non carious cervical lesions in patients with gingival recession in Egyptian population and associated risk factors including gingival biotype, keratinized tissue width, gingival…
- Trial name
- NCT05170529
- Where
- Egypt
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cervix Lesion, Cervical Cancer
Application of Plasma Circulating HPV DNA Testing to Management of Cervical Intraepithelial Neoplasia
The purpose of this study is to see if circulating HPV DNA (cHPVDNA) can be used as a noninvasive biomarker for cervical intraepithelial neoplasia (CIN) 2-3 in hopes of reducing procedures and costs for patients, as well as…
- Trial name
- NCT04274465
- Testing
- digital PCR (dPCR) assay
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Skin Cancer, Mucosal Neoplasm of Oral Cavity
Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for superficial cutaneous, mucosal or soft tissue neoplasia
- Conditions
- Skin Cancer, Mucosal Neoplasm of Oral Cavity, Soft Tissue Neoplasm
- Trial name
- NCT03886181
- Testing
- Device: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Alpha Tau Medical LTD.
Pulmonary Function Test, Phrenic Nerve Irritation
Physical Therapy on Phrenic Nerve Function
This study was conducted to investigate the effects of a designed physical therapy program on respiratory function and phrenic nerve activity in cervical disc compression.
- Conditions
- Pulmonary Function Test, Phrenic Nerve Irritation, Cervical Disc Lesion
- Trial name
- NCT05817565
- Testing
- Ultrasound (Phyaction 190 I); with a frequency of 3 MHz was used
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Cervical Squamous Cell Carcinoma In Situ, Vulvar High Grade Squamous Intraepithelial Lesion
IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3
This randomized phase II trial studies how well an IRX-2 Regimen works in treating women with cervical squamous intraepithelial neoplasia 3 or squamous vulvar intraepithelial neoplasia 3.
- Trial name
- NCT03267680
- Testing
- Cyclophosphamide, Indomethacin, IRX-2
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California