Clinical trials: Cervical Lesion
Cervical Cancer Screening
Improving Cervical Cancer Screening in Women Living With HIV Attending Chronic Disease Clinics in Semi-rural Tanzania
This study is to analyse the effect of a bundle of measures on the proportion of females being screened for cervical cancer in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO), comparing the time period before…
- Trial name
- NCT05256862
- Testing
- Data collection
- Where
- Tanzania
- Volunteers
- 2,974 people
- Sponsor
- University Hospital, Basel, Switzerland
HPV-Related Cervical Carcinoma, Low-Grade Squamous Intraepithelial Lesions
Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection
Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.
- Conditions
- HPV-Related Cervical Carcinoma, Low-Grade Squamous Intraepithelial Lesions, HPV Infection, Photodynamic Therapy
- Trial name
- NCT06052033
- Testing
- CO2
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Noncarious Cervical Lesions
Clinical Evaluation of Four Aesthetic Restorations in Non-carious Cervical Lesions
To compare the clinical performance of high-viscosity glass ionomer, flowable composite, bulkfill composite and nanohybrid composite restorations in non-carious cervical lesions (NCCLs).
- Trial name
- NCT04261140
- Testing
- EQUIA Forte Fil, Clearfil Majesty Esthetic, NexComp Flow
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Non-carious Cervical Lesions
Evaluation of Double Layer Application Using a Universal Adhesive in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of a double layer application of a universal adhesive system used as etch-and-rinse application mode in non-carious cervical lesions (NCCLs), on the 6- and 12-months clinical…
- Trial name
- NCT06474494
- Testing
- Application of one layer, Application of double layer, Etch-and-rinse application mode
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Cervical Intraepithelial Neoplasia, Papillomavirus Infections
Hexaminolevulinate Photodynamic Therapy (HAL-PDT) With Deferred Surgery Versus Surgery for High-grade Squamous Intraepithelial Lesions (HSIL)
High-grade squamous intraepithelial lesions (HSIL), encompassing cervical intraepithelial neoplasia grade 2 (CIN2) with p16 positivity and grade 3 (CIN3), are precancerous conditions that require effective intervention.
- Trial name
- Aurora (NCT07669363)
- Testing
- Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC), HAL 5% with illumination
- Where
- 28 sites in China
- Volunteers
- 230 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cervical Cancer, HPV Infection
HPV DNA Self-sampling in a General Practitioner's Office.
One of the limitations of organized cervical screening in the Czech Republic is the lack of participation in preventive gynecological examinations.
- Conditions
- Cervical Cancer, HPV Infection, Precancerous Lesion
- Trial name
- ASTRA (NCT06253169)
- Testing
- HPV DNA self-test
- Where
- 2 sites in Czechia
- Volunteers
- 2,000 people
- Sponsor
- Patient Organization Veronica
Cancer
Excision Limits of Oral Cavity Tumor by Narrow Band Imaging
This study evaluates the feasibility of the NBI technique in the detection of early cancer lesions.
- Trial name
- NBI-CAB (NCT01198119)
- Testing
- Location of the suspected lesions, Biopsy, Lesion excision/Surgery
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Oscar Lambret
Cervical Cancer
Cervical Cancer Elimination -Using Implementation Science to Evaluate Deliver and Cost Introduction of Thermal Ablation
Global elimination of cervical cancer is a feasible goal; however, the countries with the greatest disease burden also have the greatest healthcare system challenges.
- Trial name
- TIBA (NCT05472311)
- Testing
- Thermal Ablation
- Where
- Kenya
- Volunteers
- 565 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cervical Cancer, Endometrial Cancer，Endometrial Lesion & Adnexal Lesion，Ectopic Pregnancy & Infertility，Pelvic Obstructive Disorder & Genital Tract Deformity
Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology
The GLESS registry is a prospective multi-center observational registry. Data from the time of patient admission, operation, discharge, and follow-up will be collected for this registry.
- Trial name
- GLESS (NCT04096872)
- Where
- China
- Volunteers
- 9,000 people
- Sponsor
- Peking Union Medical College Hospital
Erythroplakia, Leukoplakia
Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions
This phase I trial tests whether metformin works in reducing the annual transformation (development of invasive cancer) of oral precancerous lesions into cancerous lesions.
- Conditions
- Erythroplakia, Leukoplakia, Oral Cavity Carcinoma, Proliferative Verrucous Leukoplakia
- Trial name
- NCT05536037
- Testing
- Metformin, Biopsy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Thomas Jefferson University
Cervical Intraepithelial Neoplasia
Trial to Evaluate Single- and Double- Freeze Cryotherapy in the Prevention of Cervical Neoplasia
To evaluate whether single- and double-freeze cryotherapy techniques have similar efficacy in controlling different grades of cervical intraepithelial neoplasia (CIN), and have similar side effects and complications.
- Trial name
- NCT01145781
- Testing
- Cryotherapy
- Where
- India
- Volunteers
- 440 people
- Sponsor
- Tata Memorial Hospital
Esophageal Cancer, Gastric Cancer
Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study
Cancers of the upper gastro-intestinal tract, including esophagus (gullet), stomach and small bowel, are amongst the deadliest malignancies.
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus, Gastric Atrophy
- Trial name
- PROSPERO (NCT04843397)
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Dental Cervical Non-carious Lesion
Glass Hybrid Versus Composite Restorations of Non-carious Cervical Lesions
A glass hybrid restorative system (EQUIA forte) clinically compared to a composite resin based material (Clearfil SE Bond, Filtek Supreme XT) for the treatment of dental non-carious cervical lesions.
- Trial name
- NCT02631161
- Testing
- Equia Forte, Filtek Supreme XT/Clearfil SE Bond
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Class V Dental Caries
Two Year Clinical Performance of Ion-releasing and Non Ion-releasing Composite Restorative Systems in Restoring Cervical Carious Lesions.
The goal of this clinical trial is to learn if ion releasing composite materials works to induce remineralization of caries affected dentin in adults.
- Trial name
- NCT07849426
- Testing
- Ion-releasing resin composite, Giomer based composite, Non-ion-releasing ormocer based composite
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
High Grade Cervical Epithelial Neoplasia (CIN2+)
A Prolongation of a Clinical Study to Evaluate the Efficacy of an Aqueous Gel Containing 2% (w/w) of Cidofovir, Directly Applied on the Cervix Exhibiting High Grade Squamous Intraepithelial Lesions.
The infections of high grade induced by the human papilloma viruses cause precancerous lesions of the cervical epithelium. The progression of these lesions can lead to the onset of cervical cancer.
- Trial name
- NCT02976987
- Testing
- Cidofovir
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Brugmann University Hospital
Dentin Desensitizing Agents, Dentin Hypersensitivity, Non-carious Cervical Lesions
Clinical Efficacy of Using Bioactive Desensitizer Gel
To evaluate and compare the clinical effectiveness of a Bioactive Desensitizer Gel (which releases calcium and phosphate to form hydroxyapatite) versus a standard 5% Sodium Fluoride (NaF) Varnish in reducing cervical dentin…
- Conditions
- Dentin Desensitizing Agents, Dentin Hypersensitivity, Non-carious Cervical Lesions, Dentin Hypersensitivity
- Trial name
- NCT07323693
- Testing
- Treatment
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cervical Cancer, Ovarian Tumor
The Application of Real-Time Near-infrared Imaging in Gynecological Surgery
Removing in situ and metastasis lesions completely during gynecological surgery is central to reduce the recurrence and death, and the identification of lesions in traditional gynecological surgery often depends on the experience…
- Conditions
- Cervical Cancer, Ovarian Tumor, Endometrial Carcinoma, Uterine Myomatosis
- Trial name
- NCT04224467
- Testing
- Intravenous ICG and Real-Time Near-infrared Imaging
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chen Chunlin
Non Palpable Cervical Lesions Suspicious for Metastasis
Ultrasound-Guided Hook-Wire Localization for Excision of Non-palpable Cervical Lesions Suspicious for Metastasis
The goal of this randomized controlled trial is to determine whether ultrasound-guided hook-wire localization improves surgical efficiency and accuracy compared with ultrasound-guided surgery alone for the excision of…
- Trial name
- NCT07672912
- Testing
- Ultrasound-guided hook-wire localization, Ultrasound-guided surgical excision alone
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Rusana Bark
Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma
Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions
This randomized phase II trial studies how well vandetanib works in preventing head and neck cancer in patients with precancerous head and neck lesions. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Conditions
- Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma, Precancerous Condition
- Trial name
- NCT01414426
- Testing
- vandetanib, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Cervix Uteri SIL, HPV
Regression of Cervical Precancerous Lesions and Associated Risk Factors
The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and…
- Conditions
- Cervix Uteri SIL, HPV, CIN2, CIN3
- Trial name
- RECER (NCT06147388)
- Testing
- Colposcopy
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- General University Hospital, Prague