Clinical trials: Cervical Neoplasms
Thyroid Cancer
Estimation of Economic Consequences Linked With Different Care Management Pathways of Differentiated Thyroid Cancers
The incidence of Thyroid Cancer (TC) has increased over the last thirty years, in France and worldwide. This increase is mainly due to good prognosis microPapillary TC (mPTC).
- Trial name
- ECO-THYR (NCT03787121)
- Testing
- care management pathways
- Where
- France
- Volunteers
- 361 people
- Sponsor
- University Hospital, Toulouse
Hypothyroidism, Hyperthyroidism/Thyrotoxicosis
Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid Pathology
Observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study.
- Conditions
- Hypothyroidism, Hyperthyroidism/Thyrotoxicosis, Thyroid Nodule (Benign), Thyroid Carcinoma
- Trial name
- NCT06779747
- Where
- Italy
- Volunteers
- 5,850 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Solid Tumor
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose…
- Trial name
- NCT04541108
- Testing
- Rilvegostomig, Volrustomig, Sabestomig
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- Presage Biosciences
Anal Carcinoma, Bladder Carcinoma
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and…
- Conditions
- Anal Carcinoma, Bladder Carcinoma, Breast Carcinoma, Cervical Carcinoma
- Trial name
- NCT07118176
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Cervix Cancer, Endometrium Cancer
Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.
The protocol aims at demonstrating the technical feasibility and safety of doing endomicroscopic imaging (both probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy, nCLE) during…
- Conditions
- Cervix Cancer, Endometrium Cancer, Ovarian Cancer, Carcinoma in Situ of Fallopian Tube
- Trial name
- NCT02221076
- Testing
- Confocal Laser Endomicroscopy (CLE)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Mauna Kea Technologies
Nasopharyngeal Carcinoma
Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma
Standard of care for treatment of nasopharyngeal carcinoma is chemoradiation with concurrent cisplatin. Addition of a second agent, cetuximab, which targets nasopharyngeal carcinoma cells with high EGFR protein expression, may…
- Trial name
- NCT01230476
- Testing
- Cetuximab
- Where
- Malaysia
- Volunteers
- 3 people
- Sponsor
- University of Malaya
Esophageal Dysplasia
Study of Esophageal Squamous Dysplasia Prevalence at Tenwek Hospital
Esophageal squamous cell cancer (ESCC) is common in the developing world, and is the leading cancer diagnosis at Tenwek Hospital in southwestern Kenya.
- Trial name
- STEP (NCT01981876)
- Where
- Kenya
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Tenwek Hospital
Malignant Head and Neck Neoplasm, Mucositis
Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
This randomized phase III trial studies how well gabapentin plus standard of care work compares to standard of care without Gabapentin in preventing inflammation of the mucous membranes (mucositis) in patients with stage III-IV…
- Conditions
- Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder
- Trial name
- NCT02480114
- Testing
- Educational Intervention, Gabapentin, Pain Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Oral Cancer, Oropharyngeal Cancer
Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma
The objective of this study is to evaluate the efficacy of neoadjuvant stereotactic body radiation therapy (SBRT) in combination with chemotherapy and immunotherapy, prior to radical surgery, in enhancing the 2-year event-free…
- Trial name
- NCT07402538
- Testing
- Neoadjuvant treatment of SBRT plus chemoimmunotherapy followed by surgery and postoperative radiotherapy or chemoradiotherapy, Surgery and postoperative radiotherapy or chemoradiotherapy
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Sun Yat-sen University
Cervical Intraepithelial Neoplasia
Meta-analysis of Efficacy of Topotecan
This meta-analysis was conducted to investigate the efficacy of Topotecan and other treatments for recurrent and stage IVB carcinoma of the cervix
- Trial name
- NCT01160185
- Testing
- paclitaxel, cisplatin, topotecan
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cervical Cancer
Randomized Study of Z-100 Plus Radiation Therapy to Treat Cervical Cancer
This study is a phase III, multicenter, double-blind, placebo-controlled, parallel group comparative study to evaluate the efficacy and safety of Z-100 with primary uterine cervical cancer on radiotherapy.
- Trial name
- NCT02247232
- Testing
- Z-100
- Where
- 7 sites in Japan, Malaysia and 5 more
- Volunteers
- 793 people
- Sponsor
- Zeria Pharmaceutical
HNSCC
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
A phase III, multicenter, randomized, open-label, french study comparing: Arm A : Radiotherapy alone (66 to 70 Gy; 5 fractions/week; 1fraction/day; 2 Gy/fraction) (IMRT or protontherapy) Arm B: Radiotherapy (66 to 70 Gy; 5…
- Trial name
- SANTAL (NCT02998385)
- Testing
- Cisplatin, radiotherapy
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Esophageal Cancer
Photodynamic Therapy in Treating Patients With Early Esophageal Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. This may be an effective treatment for esophageal cancer.
- Trial name
- NCT00002935
- Testing
- porfimer sodium
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute
Parathyroid Adenoma
Multicenter Registry Comparing Preoperative Imaging for Primary Hyperparathyroidism
The study aims are: 1. To compare the diagnostic performance of parathyroid four-dimensional CT (4D-CT), scintigraphy, and ultrasound in patients who underwent parathyroid surgery for primary hyperparathyroidism. 2.
- Trial name
- NCT02381925
- Sponsor
- Duke University
Advanced Cancer
Safety Study of Oral MGCD265 Administered Without Interruption to Subjects With Advanced Malignancies
In this study, MGCD265, a new anticancer drug under investigation, is given daily to patients with advanced malignancies to study its safety profile.
- Trial name
- NCT00697632
- Testing
- MGCD265
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Mirati Therapeutics Inc.
Adenocarcinoma - GEJ, Cancer of Esophagus
Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer
An open label single arm phase II trial in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma which is MGMT deficient.
- Trial name
- ELEVATE (NCT04984733)
- Testing
- Temozolomide, Temozolomide 50mg/m2/day, Temozolomide 3 month
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Southampton
Head and Neck Cancer, Lung Cancer
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00021333
- Testing
- filgrastim, cisplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 29 people
- Sponsor
- Fox Chase Cancer Center
Parotid Tumor
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors
1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added.
- Trial name
- NEFAPA (NCT04613349)
- Testing
- MRI
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Esophageal Cancer
Inter-observer Variation in Gross Tumor Delineation of Esophageal Cancer on MR, CT and PET CT
The aim of the study is to investigate inter-observer variation in gross tumor volume (GTV) delineation of oesophageal cancer on different imaging modalities - CT, PET CT and MR.Twenty-three consecutive patients with esophageal…
- Trial name
- NCT05611658
- Testing
- MR, PET CT
- Where
- Slovenia
- Volunteers
- 23 people
- Sponsor
- Institute of Oncology Ljubljana
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