Clinical trials: Cervical Spine Myelopathy
Orthopedic Disorder of Spine, Neurologic Disorder
A fMRI Study of Compressive Spinal Cord
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly.
- Trial name
- CSM Plasticity (NCT03504254)
- Testing
- MRI examination
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Cervical Spondylotic Myelopathy
Biomarkers of Cervical Spondylotic Myelopathy
Investigators believe that patients with cervical spondylotic myelopathy (CSM) have measurable changes in certain molecules in their blood compared with people without CSM.
- Trial name
- NCT07772297
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Cervical Spondylosis With Myelopathy
DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy
More than half of the middle-aged population has radiologic evidence of cervical spondylosis (Irvine 1965) and a subset of this population develops cervical spondylotic myelopathy (CSM), a condition in which the spinal cord is…
- Trial name
- NCT01868958
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Emory University
Cervical Spinal Cord Injury, Spine Injury
Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
The purpose of this study is to evaluate the safety of cross sequential escalating doses of AST-OPC1 administered among 5 cohorts at a single time-point between 21 and 42 days post injury, inclusively, to subjects with subacute…
- Conditions
- Cervical Spinal Cord Injury, Spine Injury, Spinal Cord Trauma
- Trial name
- NCT02302157
- Testing
- AST-OPC1
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Degenerative Disc Disease, Herniated Disc
Bone Graft Materials Observational Registry
A multi-center, prospective, observational patient registry to collect information on the clinical outcomes and "real world" use of approved and commercially available bone graft substitutes, autograft and allograft.
- Conditions
- Degenerative Disc Disease, Herniated Disc, Spinal Stenosis, Spondylolithesis
- Trial name
- APPROACH-001 (NCT00974623)
- Testing
- Bone graft substitute, autograft or allograft
- Where
- 14 sites in United States, Hungary and 1 more
- Volunteers
- 329 people
- Sponsor
- Baxter Healthcare Corporation
Cervical Myelopathy
The Characteristic of Axial Pain and EEG Analysis of Patients After Laminoplasty
The characteristic of axial pain and EEG analysis of patients after laminoplasty
- Trial name
- NCT04968639
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Cervical Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Establishment of the Integration of Surgery and Postoperative Intensive Recovery of Patients With CSM
This study aims to establish the specialist consensus of the integration of posterior approach surgical treatment and postoperative intensive recovery management for CSM or OPLL patients, and verify its safety, practicability and…
- Trial name
- NCT04947891
- Testing
- Intensive recovery management
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Myelopathy
Comparing Allograft to Autograft Bone in ACDF Surgeries
Anterior cervical discectomy and fusion (ACDF) is a surgery performed from the front of the neck in which damaged discs are removed and a bone graft is inserted into the space to allow the bone to grow together to set up a bridge…
- Trial name
- NCT03518164
- Testing
- Allograft
- Sponsor
- Rutgers, The State University of New Jersey
Cervical Vertebrae Injury
Effectiveness of Robot-assisted Upper-limb Exercise in Cervical SCI
The aim of the project is to test the effectiveness of robot-assisted upper-limb exercise in persons after cervical spinal cord injury.
- Trial name
- RVZU (NCT06089915)
- Testing
- Standard occupational therapy, Robot-assisted exercise using Amadeo device and Armeo Spring exoskeleton
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Cervical Degenerative Disc Disease
Multi-Centre Post-Market Data Collection
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT06413225
- Testing
- Synergy cervical disc system
- Where
- 2 sites in United Kingdom
- Sponsor
- Synergy Spine Solutions
Cervical Degenerative Disc Disease
Real World Data Collection on the Synergy Disc
This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts.
- Trial name
- NCT06383949
- Testing
- Synergy Cervical Disc system
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- Synergy Spine Solutions
Cervical Myelopathy
ERAS in Posterior Approach of Cervical Spine Operation
Enhanced recovery after surgery (ERAS) strategy has been used in the patient management of different diseases. This study aims to evaluate the effectiveness of ERAS in the perioperative period of posterior approach of cervical…
- Trial name
- NCT04962256
- Testing
- Enhanced recovery after surgery
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
Radiculopathy, Cervical, Myelopathy
A Study of Korean Society of Spine Surgery on the Outcomes of Anterior Cervical Discectomy and Fusion
The purpose of this study is firstly to determine the efficacy of cervical plate for anterior cervical discectomy and fusion using cervical cage, and secondly to investigate the determining factors for surgical outcomes.
- Trial name
- NCT01911013
- Testing
- anterior cervical discectomy and fusion, Cage and Plate, Cage alone
- Where
- 31 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Hospital
Cervical Degenerative Disc Disease, Radiculopathy
Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels
The purpose of this clinical investigation is to assess the safety and effectiveness of using the PRESTIGE-LP device in the treatment of patients with symptomatic degenerative disc disease at two adjacent levels of the cervical…
- Conditions
- Cervical Degenerative Disc Disease, Radiculopathy, Myelopathy
- Trial name
- NCT00637156
- Testing
- PRESTIGE LP device at two adjacent levels, Bi-level fusion with ATLANTIS Cervical Plate System
- Where
- 29 sites in United States
- Volunteers
- 397 people
- Sponsor
- Medtronic Spinal and Biologics
Cervical Spondylotic Myelopathy
Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy
Background: Degenerative cervical myelopathy (DCM) is characterized by neck pain, neck stiffness, weakness, paresthesia, sphincter disturbance and balance disorder.
- Trial name
- MyRanC (NCT04936074)
- Testing
- Muscle preserving selective laminectomy, Laminectomy with instrumented fusion
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University Hospital
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Cervical Myelopathy, Cervical Radiculopathy
Long-term Follow-up Motion Analysis of ACD Versus ACDA
Rationale: Cervical degenerative disc disease (CDDD) is a common cause of cervical radiculopathy, myelopathy or myeloradiculopathy.
- Conditions
- Cervical Myelopathy, Cervical Radiculopathy, Spinal Stenosis, Spinal Disease
- Trial name
- NCT04545983
- Testing
- Motion Analysis
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Zuyderland Medisch Centrum