Clinical trials: Cervical Squamous Intraepithelial Lesion
Cervical Intraepithelial Neoplasia, Squamous Intraepithelial Lesions of the Cervix
Conservative Management of HSIL in Patients With Future Pregnancy Aspiration
Conservative management of high-grade squamous intraepithelial lesions (HSILs) seems safe and justified in young women (<30 years), but evidence is insufficient on whether it is also advisable for older women.
- Conditions
- Cervical Intraepithelial Neoplasia, Squamous Intraepithelial Lesions of the Cervix, Uterine Cervical Dysplasia
- Trial name
- NCT04783805
- Testing
- Conservative management with regular follow-up, Conization
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cervical Intraepithelial Neoplasia Grade I/ II/ III (CIN I/II/III), Human Papillomavirus (HPV) Infections
A Study to Assess the Reduction of Human Papillomavirus (HPV) Viral Infectivity and Transmission in HPV-Positive Women After Vaccination With 9vHPV (RIFT-HPV)
This is a non-randomized, open label study to assess the reduction of Human Papillomavirus (HPV) infectivity and transmission in women positive for HPV16 and/or 18 in a cervical, oral and anal sample and vaccinated with…
- Conditions
- Cervical Intraepithelial Neoplasia Grade I/ II/ III (CIN I/II/III), Human Papillomavirus (HPV) Infections, High-risk HPV, HPV-16/ 18
- Trial name
- RIFT-HPV (NCT05334706)
- Testing
- Nonavalent HPV vaccine (9vHPV/Gardasil-9™).
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- Miquel Angel Pavon Ribas
I) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS)
Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer
This study compares how effective is the molecular screening (a blood test) using Pap smear as reference, that is, a comparison of these tests abilities to detect precursor lesions and cervical cancer among women of an open…
- Conditions
- I) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS), III) Cervical Intraepithelial Neoplasia (CIN), CIN-1, CIN-2, CIN-3, IV) Low-grade Squamous Intraepithelial Lesion (LSIL)
- Trial name
- NCT07480902
- Testing
- Physical examination, Liquid-based cytology, Molecular screening
- Where
- Mexico
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Timser SAPI de CV
Cervical Cancer, High Grade Sil
Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women.
Nearly 8 000 new cervical cancer cases are diagnosed in South Africa per year; many are still undiagnosed and about 50% of diagnosed cases succumb per year.
- Conditions
- Cervical Cancer, High Grade Sil, CIN2
- Trial name
- DiaVACCS (NCT02956031)
- Testing
- Screening, Colposcopy, LLETZ
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Pretoria
HPV, High-risk HPV (Any Strain)
Study Assessing Reduced HPV Infectivity and Transmission in HPV-Positive Women Following Vaccination With 9vHPV
This is a randomized, open-label trial, to assess whether a single dose of HPV nonavalent vaccine, administered to HIV uninfected, unvaccinated women with high risk HPV16/18/31/33/45/52 or 58 can decrease the infectivity of shed…
- Conditions
- HPV, High-risk HPV (Any Strain), Human Papillomavirus (HPV) Infections
- Trial name
- RIFT-SSA (NCT07303751)
- Testing
- Nonavalent HPV vaccine (9vHPV)
- Where
- Sierra Leone
- Volunteers
- 80 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Uterine Cervical Neoplasms, Cervix Intraepithelial Neoplasia
Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions
Human Papilloma Virus (HPV) infections induce cervical intraepithelial neoplasia (CIN) of cervix. To reduce incidence of invasive tumor associated with high grade CIN lesions, the standard treatment is the conisation of cervix…
- Trial name
- NCT00989443
- Testing
- Cidofovir gel
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Mithra Pharmaceuticals
Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection
Papilocare®: Effects on Regression of Histologically Confirmed Cervical Intraepithelial Lesions 1 and Tolerance
clinical trial comparing the regression rate after 12 months of histologically confirmed cervical intraepithelial lesions 1 in 2 parallel groups.
- Conditions
- Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection, Cervix Lesion
- Trial name
- PAPILOCARE (NCT04624568)
- Testing
- PAPILOCARE
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cervical Intraepithelial Neoplasia, Trichloroacetic Acid
Efficacy of Topical 85% TCA in the Treatment of LSIL After Low-grade Abnormality of Screening Test: a Randomized Controlled Trial
To determine the efficacy and HPV clearance of an application of 85% TCA compared to placebo in the treatment of LSIL. This is a randomized, single-blind, placebo-controlled study in 44 women aged 18-65 years with…
- Trial name
- Trichlosil (NCT06525870)
- Testing
- 85%TCA topical application, 3% acetic acid
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
High-grade Squamous Intraepithelial Lesion (HSIL)
Evaluation of NWRD09 for HPV-16 Related Cervical HSIL
This is a randomized, double-blind, placebo controlled Phase 2 study to determine the efficacy and safety of NWRD09 administered by intramuscular (IM) injection in adult women with histologically confirmed cervical high grade…
- Trial name
- NCT07712692
- Testing
- NWRD09 Injection
- Where
- 15 sites in China
- Volunteers
- 156 people
- Sponsor
- Newish Biotech (Wuxi) Co., Ltd.
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN)
Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV)
Persistent high-risk human papillomavirus infection is an important precursor of cervical cancer and related cervical lesions. This single-center, randomized, assessor-blinded, parallel-group controlled trial evaluates whether…
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN), Low-Grade Squamous Intraepithelial Lesions
- Trial name
- DUAL-HPV (NCT07735039)
- Testing
- Oral Immunomodulator, Vaginal Ovule, Standard Supportive Care
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
HSIL, High-Grade Squamous Intraepithelial Lesions, Vaginal Microbiome
Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated with Imiquimod
The goal of this clinical trial is to identify the immunophenotypic profile of the local immune response, the cervicovaginal microenvironment and the microbiological profile of women with CIN 3 treated with imiquimod.
- Conditions
- HSIL, High-Grade Squamous Intraepithelial Lesions, Vaginal Microbiome, Biomarkers
- Trial name
- NCT06356012
- Testing
- Imiquimod, Loop Electrosurgical Excision Procedure
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Cervical Intraepithelial Neoplasia
A Study of ABI-2280 Vaginal Insert (Previously Referred to as ABI-2280 Vaginal Tablet) in Participants With Cervical Intraepithelial Neoplasia
This is an open-label study to evaluate the safety, tolerability, and efficacy of ABI-2280 in participants with cervical squamous intraepithelial lesions. This study is divided into 2 parts - Part A and Part B.
- Trial name
- NCT05502367
- Testing
- ABI-2280 Vaginal Tablet/Insert
- Where
- 7 sites in Australia, Peru and 1 more
- Volunteers
- 44 people
- Sponsor
- Antiva Biosciences
Human Papillomavirus Clearance at 12 Months
Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions
Persistent human papillomavirus (HPV) infections is the single necessary cause of cervical cancer. Cervical cancer is still the major health problem in the developing countries.
- Trial name
- Cryotherapy (NCT00566579)
- Testing
- Cryotherapy
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Papillomavirus Infections
Efficacy of 851B Gel for Treating High-Risk Cervical Human Papillomavirus Infection in Women.
The purpose of this study was to evaluate efficacy of 851B gel over a range of concentrations and dosing regimens on high-risk cervical human papillomavirus infection in women.
- Trial name
- NCT00312286
- Testing
- 851B
- Where
- 93 sites in United States, Canada and 1 more
- Volunteers
- 538 people
- Sponsor
- Takeda
Cervix Uteri SIL, HPV
Regression of Cervical Precancerous Lesions and Associated Risk Factors
The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and…
- Conditions
- Cervix Uteri SIL, HPV, CIN2, CIN3
- Trial name
- RECER (NCT06147388)
- Testing
- Colposcopy
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- General University Hospital, Prague
Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)
Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.
P16INK4a has recently been described as a surrogate marker for HR-HPV associated squamous and glandular intraepithelial lesions of the cervix.
- Trial name
- NCT00343213
- Testing
- colposcopy
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
High-Grade Squamous Intraepithelial Lesions
Laser Ablation in the Treatment of High-grade Cervical Lesions
Cervical laser ablation is an effective, minimally invasive treatment with a low incidence of perinatal complications and minimal impact on fertility.
- Trial name
- NCT06333743
- Testing
- laser ablation, LEEP or Conization
- Volunteers
- 308 people
- Sponsor
- Peking Union Medical College Hospital
HSIL, High-Grade Squamous Intraepithelial Lesions, Adenocarcinoma in Situ
In the Era of the HPV Vaccine, What Are The Current HPV Subtypes Contributing to High Grade Cervical Dysplasia, Adenocarcinoma in Situ, and Early Cervical Cancer?
This study will look at cervical tissue samples in women with abnormal cervical cells to see if the frequency of the HPV 16/18 subtypes has changed in female populations today, after the introduction of the HPV vaccine.
- Conditions
- HSIL, High-Grade Squamous Intraepithelial Lesions, Adenocarcinoma in Situ, Early Cervical Cancer
- Trial name
- NCT02937155
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Human Papillomavirus, High-Grade Squamous Intraepithelial Lesions
Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
The purpose of this research study is to test the safety and effectiveness of the investigational study vaccine, called TVGV-1. The study will test the vaccine in women with high grade HPV cervical infection.
- Trial name
- NCT02576561
- Testing
- TVGV-1, GPI-0100
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- THEVAX Genetics Vaccine
Squamous Intraepithelial Lesions, Laser Burn
Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions
Using multiple targeting CO2 laser ablation to treat the precancerous lesion of the female lower anogenital tracts and analyzing the data collected in the study, we aim to form the standard strategy of laser ablation method to…
- Trial name
- NCT05170620
- Testing
- laser ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital