Clinical trials: Cervix
Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection
Papilocare®: Effects on Regression of Histologically Confirmed Cervical Intraepithelial Lesions 1 and Tolerance
clinical trial comparing the regression rate after 12 months of histologically confirmed cervical intraepithelial lesions 1 in 2 parallel groups.
- Conditions
- Squamous Intraepithelial Lesions of the Cervix, Human Papilloma Virus Infection, Cervix Lesion
- Trial name
- PAPILOCARE (NCT04624568)
- Testing
- PAPILOCARE
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
HSIL of Cervix
Clinical Study of HPV Therapeutic DNA Vaccine (NWRD08) in Patients With Cervical HPV16 and/or HPV18 Positive
This is an open-label exploratory clinical study. The main objective is to explore the immunogenicity of HPV therapeutic DNA vaccine NWRD08.
- Trial name
- NCT05905354
- Testing
- NWRD08
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Newish Technology (Beijing) Co., Ltd.
Uterine Cervical Neoplasms, Cancer of Cervix
Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors
This is a phase II trial of combination therapy of cadonilimab(Bispecific Anti-PD-1/CTLA-4 Antibody) plus nab-Paclitaxel in patients with recurrent or metastatic cervical cancer that had failed PD-1/PD-L1 blockade therapy.
- Conditions
- Uterine Cervical Neoplasms, Cancer of Cervix, Cervical Cancer, Cervical Neoplasms
- Trial name
- NCT05824494
- Testing
- Cadonilimab, Nab paclitaxel
- Volunteers
- 58 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Head and Neck Cancers, Lung and Esophagus Cancers
Adaptive Pet Study
The purpose of this study is to determine the benefit of using positron emission tomography (PET) in addition to the standard (computed tomography) CT to plan radiation therapy for cancer treatment.
- Conditions
- Head and Neck Cancers, Lung and Esophagus Cancers, Anal, Cervix, Vulvar, Vaginal, and Endometrium Cancers
- Trial name
- NCT01908504
- Testing
- PET-CT
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Duke University
Cervix Cancer
Impact of HPV on a Cohort of Southern Italian Women: Epidemiological, Clinical, Morphological and Microbiological Features
HPV is known to be the causal agent in the majority of cervical cancers. However, the role of the cervical bacterial microbiome in cervical cancer is not clear
- Trial name
- NCT03959410
- Testing
- Cervical biopsy
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Birth, Short Cervix
Canadian Study on the Association of Pessary With Progesterone
Prematurity is the leading cause of neonatal morbidity causing more than 1 million deaths worldwide per year. In 2012, a randomized controlled trial (RCT) testing "pessary" (silicone ring placed around the cervix) versus "no…
- Trial name
- CAPP (NCT03227705)
- Testing
- Prometrium, Dr. Arabin, cerclage pessary perforated
- Where
- 8 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Adenocarcinoma of the Uterine Cervix
Adenocarcinoma of the Uterine Cervix and HPV
The present study will mainly aim to review and characterize the pathologic features, treatment options, and follow-up outcomes of women with in situ/microinvasive adenocarcinoma of the uterine cervix according to HPV status…
- Trial name
- NCT05267834
- Testing
- Conization and/or Hysterectomy
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- Università Politecnica delle Marche
Precancerous Condition
Activating Collaborative CIS Support Via Targeted Provider Mailing
RATIONALE: Receiving a reminder letter from their doctor with questions to ask the Cancer Information Service may be more effective than a standard reminder letter in helping patients who have had an abnormal Pap test keep their…
- Trial name
- NCT00873288
- Testing
- Usual care mailing intervention, CIS support mailing intervention
- Where
- 2 sites in United States
- Volunteers
- 254 people
- Sponsor
- Northwestern University
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
Cervix Cancer, HPV Testing
Screening Triage and Risk Stratification
To investigate the performance of cytology, extended genotyping, p16/Ki67 dual stain cytology, DNA methylation and viral load as triage markers in post-menopausal HPV-screen-positive women aged 50-64 years in the organized…
- Conditions
- Cervix Cancer, HPV Testing, Postmenopausal Women
- Trial name
- I-share (NCT05727228)
- Testing
- cytology, p16/ki67 dual stain cytology (DS), extended genotyping, DNA methylation, viral load,
- Where
- Denmark
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cancer of Cervix, Laparoscopic Surgery
Minimally Invasive Therapy Versus Open Radical Hysterectomy for Management of Early Stage Cervical Cancer
Radical hysterectomy and pelvic lymph node dissection (+/- aortic lymph node dissection) is the standard treatment for early stage cervical cancer.
- Trial name
- MITOR (NCT04999696)
- Testing
- radical hysterectomy
- Where
- Taiwan
- Volunteers
- 820 people
- Sponsor
- Chang Gung Memorial Hospital
Cervical Intraepithelial Neoplasia Grade 2/3, Neoplasm Cervix
Evaluation of in Vitro Devices on Self-collected Vaginal Swab and Urine Sample for Testing of Human Papilloma Virus
The European VALHUDES study is a Clinical Performance /Diagnostic Test Accuracy Study that aims to evaluate whether HPV testing with new assays performed on self-samples, collected by means of a vaginal and a urine collection…
- Conditions
- Cervical Intraepithelial Neoplasia Grade 2/3, Neoplasm Cervix, Carcinoma in Situ, Carcinoma Cervix Uterine
- Trial name
- EU-VALHUDES (NCT04312737)
- Testing
- Self-Collecting Devices, In Vitro Diagnostic Assays
- Where
- 6 sites in Ireland, Italy and 1 more
- Volunteers
- 600 people
- Sponsor
- Hiantis Srl
Papilloma, Cervix Lesion
Effect of Natural Compounds on the Severity of HPV-induced Cervical Lesions
To test the efficacy of a newly-commercialized formula, 40 HPV-positive women displaying chronic cervicitis, mild dysplasia or moderate dysplasia.
- Trial name
- NCT05625308
- Testing
- Epigallocatechin gallate, Folic acid, Vitamin B12, and Hyaluronic Acid
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Lo.Li.Pharma s.r.l
Cervix Cancer
Plan of the Day Radiotherapy
The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.
- Trial name
- NCT05634681
- Testing
- Plan of the day, Standard plan
- Where
- Norway
- Volunteers
- 190 people
- Sponsor
- Oslo University Hospital
Cervix Cancer
Optimized Magnetic Resonance Brachytherapy (MR BT) in Cervix Cancer
Patients with cervix cancer usually require external radiation given to the whole pelvis then an internal radiation boost, also called brachytherapy, to treat any remaining tumour.
- Trial name
- NCT00938106
- Testing
- optimised magnetic resonance image-guided intra-uterine brachytherapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Algorithm for Cervix Carcinoma Screening
Algorithm for Cervix Carcinoma Screening in CZ Using the Detection of HPV DNA and CINtec Plus
Cervix carcinoma has been a serious, long-term issue in the Czech Republic. The cause of nearly all cervix carcinomas is human papilomavirus (HPV).
- Trial name
- LIBUSE (NCT05578833)
- Testing
- HPV DNA test with selective HPV 16/18 genotyping (cobas® 4800 HPV Test, Roche), p16 and Ki-67 biomarker detection in the form of dual cytological staining (CINtec Plus, Roche), standard conventional cytology PAP test
- Where
- Czechia
- Volunteers
- 2,426 people
- Sponsor
- AeskuLab Pathology Prague
Uterine Neoplasms, Cervix Neoplasms
Combidex USPIO - Ultra-small Superparamagnetic Iron Oxide
The purpose of this study is to test whether or not a new contrast agent called Combidex, a contrast agent formulated from ultra-small superparamagnetic iron oxide (USPIO) improves the ability of Magnetic Resonance Imaging (MRI)…
- Conditions
- Uterine Neoplasms, Cervix Neoplasms, Bladder Neoplasms, Prostatic Neoplasms
- Trial name
- NCT00188695
- Testing
- MRI contrast agent Combidex (ferumoxtran-10)
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University Health Network, Toronto
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Colorectal Cancer, Breast Cancer
Effectiveness of Care in Certified Cancer Centres in Germany
Assessment of the effectiveness of care in certified cancer centres for eight cancer entities via a retrospective cohort study based on secondary data from statutory health insurance funds and population-based clinical cancer…
- Conditions
- Colorectal Cancer, Breast Cancer, Ovarian Cancer, Cervix Cancer
- Trial name
- WiZen (NCT04334239)
- Testing
- Oncological certification
- Where
- Germany
- Volunteers
- 670,000 people
- Sponsor
- Technische Universität Dresden