Clinical trials: Cervix
Mullerian Anomaly of Vagina, Mullerian Anomaly of Uterus, Nec
Diagnostic, Therapeutic and Reproductive Aspects of Patients With Mullerian Anomalies (MULAN)
The purpose of this study is to get a better understanding of the clinical implications (including reproductive problems and obstetric complications), appropriate diagnostic tools and correct surgical treatment of Mullerian…
- Conditions
- Mullerian Anomaly of Vagina, Mullerian Anomaly of Uterus, Nec, Mullerian Anomaly of Cervix
- Trial name
- MULAN (NCT04732546)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Ghent
Preterm Birth, Pregnancy, High Risk
Inpatient vs Outpatient Management of Short Cervix
The presence of short cervix during pregnancy is a risk factor for preterm birth though in many cases women will eventually deliver at term or near term.
- Trial name
- NCT03979196
- Testing
- Inpatient Management, Outpatient Management
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Birth
Cerclage for the Reduction of Extreme Preterm Birth in Twin Pregnancies With a Short Cervix or Dilatation
The goal of this clinical trial is to assess the effectiveness of a cerclage in women with a twin pregnancy with a midpregnancy short cervix or cervical dilatation compared to standard treatment (no cerclage) in the prevention of…
- Trial name
- TWIN Cerclage (NCT05968794)
- Testing
- Vaginal cerclage
- Where
- 13 sites in Belgium, Netherlands
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Labor Pain
Epidural Analgesia in Different Cervix Diameter and the Rate of Cesarean Delivery
Epidural analgesia in the early stage of labor at cervix < 4.0cm was considered as a risk period for increasing the rate of cesarean delivery.
- Trial name
- EACDRCD (NCT00677274)
- Testing
- Epidural labor analgesia
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Nanjing Medical University
Preterm Birth, Twin Pregnancy
Pessary Versus Cerclage With or Without Progesterone in Twins
This study compares the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone for prevention of preterm birth in women with a twin pregnancy and a cervix ≤28 mm.
- Conditions
- Preterm Birth, Twin Pregnancy, Short Cervix
- Trial name
- PCP-Twins (NCT03863613)
- Testing
- Pessary, Cervical cerclage, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 219 people
- Sponsor
- Mỹ Đức Hospital
Squamous Cell Lung Cancer, Vulvar Cancer
Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations
Interventional study evaluating the efficacy of an immunotherapy (pembrolizumab) in combination with a targeted therapy (vorinostat) in patient with recurrent and/or metastatic squamous cell carcinoma (localisations : head and…
- Conditions
- Squamous Cell Lung Cancer, Vulvar Cancer, Penile Cancer, Cervix Cancer
- Trial name
- PEVOsq (NCT04357873)
- Testing
- pembrolizumab; vorinostat
- Where
- 14 sites in France
- Volunteers
- 112 people
- Sponsor
- UNICANCER
Cervix Cancer
Evaluation of the Diagnostic and Prognostic Value of Immunohistochemical Markers in Precancerous Lesions of the Cervix
The study aims to evaluate the expression of certain proteins and their diagnostic and prognostic value in precancerous lesions of the cervix.
- Trial name
- NCT06852157
- Testing
- Tissue, diagnostic and prognostic accuracy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Neoplasms, Endometrial Neoplasms
Chemotherapy With Whole Body Hyperthermia to Treat Resistant Breast, Endometrial, Cervical and Ovarian Cancers
Thermal therapy (hyperthermia of heat) can increase the effect of chemotherapy treatments. By itself, thermal therapy can also kill cancer cells.
- Conditions
- Breast Neoplasms, Endometrial Neoplasms, Cervix Neoplasms, Ovarian Neoplasms
- Trial name
- NCT00178802
- Testing
- thermochemotherapy (with 5-fluorouracil/interferon-a/liposomal doxorubicin)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Labor Fast
Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor
Although Hyoscine N butyl bromide (HBB) is used liberally to facilitate cervical dilatation, there is little and inconclusive data about its efficacy.
- Trial name
- HBB (NCT02098889)
- Testing
- hyoscine-N-butyl bromide(HBB), Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary
Optical Detection of Peripheral Nerve Bundles During Surgery
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue.
- Conditions
- Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary, Malignant Lymphoma of Lymph Nodes of the Cervix, Carcinoma of Parotid Gland
- Trial name
- NerveSpect (NCT01731379)
- Testing
- Surgical resection
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Philips Healthcare
Cancer Uterus Cervix
Respiration After Robot Assisted Laparoscopic Hysterectomy
The study will investigate how respiratory function is affected by robot-assisted surgery. Previous studies have investigated the impact after open and laparoscopic surgery, but there are no studies yet after robot-assisted…
- Trial name
- REHYR (NCT06806280)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Cervical Cancer
Sexual Functioning in Cervical Cancer Survivors
Objectives: Primary Objectives: To assess the entire range of sexual functioning (desire, arousal, orgasmic capacity, dyspareunia, and sexual satisfaction) over the course of treatment and early follow-up in patients with local…
- Trial name
- NCT00522223
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- M.D. Anderson Cancer Center
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16 fractions, once a day) after…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239626
- Testing
- POHIM-RT
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Cervical Ripening, Unfavorable Cervix
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Twenty-two percent of deliveries in France are induced. In cases where labor is induced and cervix is unfavorable, cervical ripening prior oxytocin administration is advised in order to reduce the risk of cesarean delivery.
- Trial name
- OPIC (NCT04949633)
- Testing
- Prostaglandins, Oxytocin
- Where
- 14 sites in France
- Volunteers
- 1,494 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cervical Neoplasia
Human Papillomavirus (HPV) and Risk of Cervical Precancer and Cancer
Background: In most women, HPV infection does not cause symptoms and the infection goes away on its own. In a small percentage of women, the HPV infection does not go away and sometimes can result in cervical precancer or cancer.
- Trial name
- NCT00435214
- Where
- United States
- Volunteers
- 131,110 people
- Sponsor
- National Cancer Institute (NCI)
Human Papillomavirus (HPV) Infection, Cervical Cancer
Cnidium Monnieri Detoxification Formula for Persistent High-risk Human Papillomavirus Infection of Cervix.
The purpose of this study is to evaluate the clinical efficacy and safety of Cnidium Monnieri Detoxification Formula in clearing HPV infection, improving clinical symptoms and quality of life in female patients with persistent…
- Trial name
- NCT06705322
- Testing
- Cnidium Monnieri Detoxification Formula
- Volunteers
- 79 people
- Sponsor
- Fudan University
Cervical Cancer
Oxaliplatin in Treating Patients With Recurrent or Refractory Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of oxaliplatin in treating patients who have recurrent or…
- Trial name
- NCT00005837
- Testing
- oxaliplatin
- Where
- 72 sites in United States, Canada
- Sponsor
- Gynecologic Oncology Group
HIV Infections, Cervix, Dysplasia
Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
The purpose of this study is to see if it is safe and effective to give isotretinoin to HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
- Trial name
- NCT00001073
- Testing
- Isotretinoin
- Where
- 40 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervix Cancer, HPV Testing
Screening Triage and Risk Stratification
To investigate the performance of cytology, extended genotyping, p16/Ki67 dual stain cytology, DNA methylation and viral load as triage markers in post-menopausal HPV-screen-positive women aged 50-64 years in the organized…
- Conditions
- Cervix Cancer, HPV Testing, Postmenopausal Women
- Trial name
- I-share (NCT05727228)
- Testing
- cytology, p16/ki67 dual stain cytology (DS), extended genotyping, DNA methylation, viral load,
- Where
- Denmark
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cervical Cancer, Precancerous Condition
Identifying Biomarkers for Early Detection of Cancer in Patients With Cervical Dysplasia or Carcinoma in Situ of the Cervix
RATIONALE: Studying the genes expressed in samples of tissue from patients with abnormal cells may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00601601
- Volunteers
- 80 people
- Sponsor
- British Columbia Cancer Agency