Clinical trials: Cervix
Focus: Prevent Preterm Delivery, Incidental Short Cervix at Mid-trimester
Arabin Pessary Combine With Vaginal Progesterone Compare With Vaginal Progesterone Alone to Prevent Preterm Delivery in Singleton Pregnancies
1. This will be a randomized prospective and open-label study with no placebo control or blinding of the participants and the research team members.
- Trial name
- NCT03052270
- Testing
- Arabin Pessary
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Preterm Labor
Use of Pessary in Case of Cervical Insufficiency and Short Cervix
Prematurity is the most important cause of obstetric morbidity and mortality. Health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human…
- Trial name
- NCT03096691
- Testing
- cervical pessary
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Cervical Cancer
Evaluate Efficacy of the Association Nimotuzumab(HR3) /Cisplatin-Vinorelbine on Patients With Cervical Carcinom
The objective of the present study is to estimate the overall survival of patients with cervical cancer after the administration of monoclonal antibody (mAb) Nimotuzumab (hR3) in combination with chemotherapy of first intention.
- Trial name
- CIMAHOPE (NCT03413579)
- Testing
- Nimotuzumab ( h-R3)
- Where
- 5 sites in Algeria
- Volunteers
- 37 people
- Sponsor
- El Kendi Pharmaceuticals Manufacturing Company
Scarred Uterus
A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix
Increasing cesarean rate in France is worrying. Different methods are described for ripening labor : the use of prostaglandins is described but maybe dangerous for patients with scarred uterus and is not recommended.
- Trial name
- NCT01711060
- Testing
- oxytocin, balloon catheter
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- Poitiers University Hospital
Cervical Cancer, Cervix Cancer
Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda
This phase II trial compares the effect of hypofractionated radiotherapy (HFRT) to conventional fractionated radiotherapy (CFRT) when given in combination with cisplatin and brachytherapy in patients with stage IB3, II, or III…
- Conditions
- Cervical Cancer, Cervix Cancer, Cervical Adenocarcinoma, Cervical Small Cell Carcinoma
- Trial name
- HypoRTCx-UG (NCT07276360)
- Testing
- Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin
- Where
- Uganda
- Volunteers
- 278 people
- Sponsor
- Uganda Cancer Institute
Asherman's Syndrome, Endometrium; Atrophy, Cervix
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
- Trial name
- BMSCT (NCT02144987)
- Testing
- Bone Marrow CD133+ Stem Cell Transplantation
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
ASC-US, Human Papilloma Virus
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis.
- Trial name
- NCT03903952
- Testing
- Vitamin B12 and folate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Educational Problems, Cervix, Dysplasia
Colposcopy Education Using Operant Learning
Images will be collected during routine colposcopy and paired with their pathology results to be used for resident education
- Trial name
- Colpo (NCT04340011)
- Testing
- Colposcopy
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Human Papillomavirus Infection
The Human Papillomavirus (HPV) Transmission Pilot Study
This transmission pilot study is a prospective study to determine feasibility of enrolling female partners into an international transmission study. Companion study to MCC-13930.
- Trial name
- NCT00823511
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cervical Dysplasia, Vulvar Dysplasia
OCT-AF Imaging of Pre-cancers of Vulva and Cervix
The multimodal imaging technology, OCT-AFI, will be used to image sites on the cervix, the endocervical canal and vulva. The imaging probe is small enough, it can be inserted into the endocervical canal for imaging.
- Conditions
- Cervical Dysplasia, Vulvar Dysplasia, Precancerous Lesions, Vulvar Cancer
- Trial name
- NCT03285841
- Testing
- OCT-AFI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer
MR- PET Guided Biologically Optimised Interstitial Brachytherapy
The proposed two stage study will evaluate patterns of local recurrence after EBRT and brachytherapy in spatial reference to baseline functional MRI and FLT/F-Miso PET scan in patients undergoing chemoradiotherapy for…
- Trial name
- MR-PET Brachy (NCT01391065)
- Testing
- MR PET Guided Brachytherapy
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Tata Memorial Hospital
Twin; Pregnancy, Affecting Fetus or Newborn
Effect of Cervical Cerclage With Vaginal Progesterone in Asymptomatic Twin Pregnancies With a Sonographic Short Cervix
The objective of the present study is to evaluate the effectiveness of vaginal progesterone and cervical cerclage each alone and in combination in improving gestational age in twin pregnancy and its subsequent impact on perinatal…
- Trial name
- NCT03781466
- Testing
- Cervical cerclage, vaginal progesterone
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Aswan University Hospital
Uterine Cervical Neoplasms, Cancer of Cervix
Cadonilimab Plus Nab -Paclitaxel for Patients With Recurrent, or Metastatic Cervical Cancer Resistant to Immune Checkpoint Inhibitors
This is a phase II trial of combination therapy of cadonilimab(Bispecific Anti-PD-1/CTLA-4 Antibody) plus nab-Paclitaxel in patients with recurrent or metastatic cervical cancer that had failed PD-1/PD-L1 blockade therapy.
- Conditions
- Uterine Cervical Neoplasms, Cancer of Cervix, Cervical Cancer, Cervical Neoplasms
- Trial name
- NCT05824494
- Testing
- Cadonilimab, Nab paclitaxel
- Volunteers
- 58 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Cervical Cancer
Safety Study of Nelfinavir + Cisplatin + Pelvic Radiation Therapy to Treat Cervical Cancer
Nelfinavir will increase the efficacy of Cisplatin based chemo- radiation therapy for locally advanced cervical cancer.
- Trial name
- NCT01485731
- Testing
- Nelfinavir, Cisplatin, Pelvic External Beam Radiation Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Miami
Cervix Uteri Dilation
Effectiveness and Safety Evaluation of Aqueduct 100-device
Evaluation of efficacy and safety of using Aqueduct -100 - Cervical Dilator Device, focusing on diagnostic or operative hysteroscopies.
- Trial name
- NCT02959567
- Testing
- Aqueduct 100 dilation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Aqueduct Medical Ltd
Ovary Cancer, Endometrial Cancer
Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)
The primary purpose of the study is to determine which of four components (symptom-burden tailored app, exercise partner, oncology provider engagement, coaching) added to a core intervention of a wearable activity tracker and…
- Conditions
- Ovary Cancer, Endometrial Cancer, Uterine Cancer, Cervical Cancer
- Trial name
- NCT05743517
- Testing
- Fit4Treatment
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Northwestern University
Twin; Pregnancy, Affecting Fetus or Newborn
Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation
The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.
- Trial name
- NCT03781674
- Testing
- progesterone 400mg, progesterone 200mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Cancer of Cervix
Concomitant Chemoradiation in Advanced Stage Carcinoma Cervix
A study to evaluate the efficacy of concomitant chemoradiation as compared to radiotherapy alone. Concomitant chemoradiation is not a new treatment modality for carcinoma cervix.
- Trial name
- CRACx (NCT00193791)
- Testing
- CT + RT
- Where
- India
- Volunteers
- 850 people
- Sponsor
- Tata Memorial Hospital
Cervix Cancer, Human Papilloma Virus
Relational Agents in Cervical Cancer Education (RACE)
The goal of this clinical trial is to assess the feasibility of using interactive teaching to educate cervical cancer patients about Human papillomavirus (HPV) and HPV vaccinations.
- Conditions
- Cervix Cancer, Human Papilloma Virus, Vaginal Cancer, Vulvar Cancer
- Trial name
- RACE (NCT06537687)
- Testing
- Control, Intervention
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Radhika Gogoi
Carcinoma of the Cervix, Carcinoma or Carcinosarcoma of the Uterus
Suitability of DCE-MRI for Detection of Vascular Changes After VBT
This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.
- Trial name
- NCT01991808
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Abramson Cancer Center at Penn Medicine