Clinical trials: Cervix
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Preterm Birth, Short Cervix
Canadian Study on the Association of Pessary With Progesterone
Prematurity is the leading cause of neonatal morbidity causing more than 1 million deaths worldwide per year. In 2012, a randomized controlled trial (RCT) testing "pessary" (silicone ring placed around the cervix) versus "no…
- Trial name
- CAPP (NCT03227705)
- Testing
- Prometrium, Dr. Arabin, cerclage pessary perforated
- Where
- 8 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Malnutrition; Protein, Cancer, Lung
Effect of NUTRICAN to Improve Nutritional Status in Cancer Patients
The goal of this clinical trial is to evaluate the efficacy oral nutrition supplement (ONS) in malnutrition/high risk malnutrition cancer patients. The main questions it aims to answer: 1.
- Conditions
- Malnutrition; Protein, Cancer, Lung, Cancer Cervix
- Trial name
- NCT06128694
- Testing
- NUTRICAN
- Where
- Indonesia
- Volunteers
- 108 people
- Sponsor
- Kalbe International Pte. Ltd
Cervical Cancer
Cisplatin Plus One-Day 24-hour Infusion of High-Dose 5-Fluorouracil for Stage IVB, Recurrent or Metastatic Carcinoma of the Uterine Cervix
Objectives: To evaluate the effectiveness and toxicity of the combination of infusional cisplatin and 24-hour infusion of high-dose fluorouracil plus leucovorin (P-HDFL) repeatedly every 21 days for the treatment of stage IVB…
- Trial name
- NCT02207660
- Testing
- Cisplatin,P-HDFL
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Low-Grade Intraepithelial Neoplasia of Cervix
Evaluation of Oral EGCG Treatment for L-SIL Associated With HPV Infection
The study aims to evaluate the effectiveness of the synergy of oral Epigallocatechin Gallate as a treatment for Low-grade Cervical Lesions (L-SIL) associated with Human Papilloma Virus (HPV) infection.
- Trial name
- EGCG-HPV (NCT06314113)
- Testing
- Epigallocatechin Gallate
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Cervical Cancer, Cervix Cancer
Hypofractionated Radiotherapy for the Treatment of Locally Advanced Cervical Cancer in Uganda
This phase II trial compares the effect of hypofractionated radiotherapy (HFRT) to conventional fractionated radiotherapy (CFRT) when given in combination with cisplatin and brachytherapy in patients with stage IB3, II, or III…
- Conditions
- Cervical Cancer, Cervix Cancer, Cervical Adenocarcinoma, Cervical Small Cell Carcinoma
- Trial name
- HypoRTCx-UG (NCT07276360)
- Testing
- Hypofractionated Radiation Therapy, Conventional Fractionated Radiotherapy, Cisplatin
- Where
- Uganda
- Volunteers
- 278 people
- Sponsor
- Uganda Cancer Institute
High-grade Squamous Intraepithelial Lesions of the Cervix Associated With Human Papillomavirus (HPV) Type 16 and/or HPV Type 18 Infection
Evaluation of the Safety, Tolerability, Immunogenicity and Preliminary Efficacy of BBM-C101 Injection in Patients With Cervical High-Grade Squamous Intraepithelial Lesion(HSIL)
The goal of this study is to learn about the safety, tolerability, immunogenicity and preliminary efficacy of BBM-C101 injection in patients with High-Grade Squamous Intraepithelial Lesion of the cervix.
- Trial name
- NCT07668960
- Testing
- BBM-C101
- Where
- 4 sites in China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mianyi Biopharmaceutical Co., Ltd.
Cancer Prevention, Cervix
A Mixed-Methods Approach to Understanding Factors Associated With Cervical Cancer Screening Utilization Among Low-Income, HIV-Positive Women
The goal of this study is to better understand the factors that might prevent HIV-positive women from having routine pap smear screenings.
- Trial name
- NCT01605656
- Testing
- Cognitive Interview, Questionnaires, Focus Groups
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Twin Pregnancy
Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE)
Randomized, opened multicentric study evaluating the Effectiveness of Pessary in the patients with a Gemellary pregnancy and a collar runs between 20 and 28 weeks of amenorrhoea
- Trial name
- EPEGE (NCT00502190)
- Testing
- Silicon ring positioned in the vagina, around the cervix
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer-associated Thrombosis, Venous Thromboembolism
The Gynecological Cancer Associated Thrombosis (GynCAT) Study
GynCAT is a prospective cohort study that will be conducted on female patients with gynecologic malignancies scheduled for systemic antineoplastic treatment, aiming at development and validation of a Risk Assessment Model (RAM)…
- Conditions
- Cancer-associated Thrombosis, Venous Thromboembolism, Gynecologic Cancer, Ovarian Cancer
- Trial name
- GynCAT (NCT06284343)
- Testing
- Anticoagulant
- Where
- Italy
- Volunteers
- 1,800 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)
Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.
P16INK4a has recently been described as a surrogate marker for HR-HPV associated squamous and glandular intraepithelial lesions of the cervix.
- Trial name
- NCT00343213
- Testing
- colposcopy
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Cervix; Pregnancy, Cervical Stiffness
Pregnolia System Intra-observer Variability
The Pregnolia System is a CE-marked medical device assessing the mechanical stiffness of cervical tissue in women. The Pregnolia Probe has been engineered to minimize the influence of differences in handling and technique by the…
- Trial name
- NCT05200117
- Testing
- Pregnolia System
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pregnolia AG
Cervical Cancer, Cervix Cancer
Minimally Invasive Simple Hysterectomy in Low Risk Cervical Cancer
The rationale of the present study is to assess the safety of the minimally invasive surgery approach in patients meeting the SHAPE trial inclusion criteria.The SHAPE trial was designed to answer the clinical question of whether…
- Trial name
- LASH (NCT06416748)
- Testing
- Minimally invasive simple hysterectomy
- Where
- Italy
- Volunteers
- 974 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Human Papillomavirus Infections
Safety, Reactogenicity and Immunogenicity of Adenovirus Serotype 26 (Ad26)- and Modified Vaccinia Ankara (MVA)-Vectored Vaccine Components in Otherwise Healthy Women With HPV16 or HPV18 Infection of the Cervix
The main purpose of this study is to assess safety and reactogenicity of the 3 vaccine regimens.
- Trial name
- NCT03610581
- Testing
- Ad26.HPV16, Ad26.HPV18, MVA.HPV16/18
- Where
- 12 sites in United States, Belgium
- Volunteers
- 9 people
- Sponsor
- Janssen Vaccines & Prevention B.V.
Cervix Carcinoma
Use of High-Resolution Microendoscopy (HRME) in Patients With Adenocarcinoma In-Situ (AIS) of the Cervix
The goal of this clinical research study is to learn if it is possible to get high-resolution microendoscopy (HRME) images of AIS tissue and/or tissue from microinvasive carcinoma right before a biopsy of the cervix.
- Trial name
- NCT02206048
- Testing
- Proflavine, High-Resolution Microendoscopy (HRME) Imaging
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
ASC-US, LSIL
HPV Test of Urine and Self Collected Vaginal Samples for Cervical Cancer Screening Study
This study is a prospective observational study of human papillomavirus (HPV) testing using urine and self-collected vaginal samples for women who have atypical squamous cells of undetermined significance(ASCUS) or low grade…
- Trial name
- NCT03409471
- Testing
- Flocked Swab, Cervical Brush, HPV assay
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea University Guro Hospital
Human Papilloma Virus Infection, Carcinoma in Situ of Uterine Cervix
Community-Driven Cervical Cancer Prevention in Western Kenya
There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies.
- Trial name
- NCT02124252
- Testing
- Community-based testing with standard linkage to care, Community-based HPV testing with enhanced linkage to care
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Cancer of the Uterine Cervix
Feasibility and Acceptability of Offering Self-sampling to Non-attendees in Primary Care
The purpose of this study is to determine whether human-papillomavirus (HPV) self-sampling can be used as a primary screening test for unscreened women.
- Trial name
- DEPIST (NCT02698423)
- Testing
- Cobas HPV DNA Test, Papanicolau test
- Volunteers
- 667 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Twin; Pregnancy, Affecting Fetus or Newborn
Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation
The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.
- Trial name
- NCT03781674
- Testing
- progesterone 400mg, progesterone 200mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Carcinoma of the Cervix, Carcinoma or Carcinosarcoma of the Uterus
Suitability of DCE-MRI for Detection of Vascular Changes After VBT
This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.
- Trial name
- NCT01991808
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Abramson Cancer Center at Penn Medicine