Clinical trials: Cervix Neoplasms
Cervical Cancer
Radical Trachelectomy for Women With Early Stage Cervical Cancer
The goal of this research study is to learn about quality of life, sexual functioning, and symptoms in women who have undergone abdominal radical trachelectomy for cervical cancer. This is an investigational study.
- Trial name
- NCT00813007
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Cancer, Genital Wart
A Phase Ⅲ Study to Evaluate the Efficacy, Immunogenicity, Safety of Quadrivalent HPV Recombinant Vaccine in Chinese Healthy Females
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 4-valent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine (Hansenula Polymorpha) in Chinese Female Subjects Aged 18-45…
- Conditions
- Cervical Cancer, Genital Wart, CIN1, CIN2
- Trial name
- NCT05584332
- Testing
- Quadrivalent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- China
- Volunteers
- 3,131 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Hemorrhoidal Disease, Cervical Cancer Radiation Complications
A Clinical Study on Alleviating Hemorrhoids-related Symptoms of Pelvic Radiation Therapy
The goal of this clinical trial is to reduce the acute hemorrhoids-related symptoms for cervical cancer patients with hemorrhoids who need postoperative pelvic radiation therapy, including prolapse, local burning, bleeding…
- Trial name
- ACS-RT (NCT07175584)
- Testing
- anal canal-sparing techniques
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Carcinomas, Cervix Cancer
Phase II Study of AK104 (Cadonilimab) for Recurrent Small Cell Neuroendocrine Carcinomas of the Cervix
This is a Phase 2, single center, open-label, single-arm study designed to evaluate the efficacy, safety, tolerability, and immunogenicity of AK104 monotherapy in adult subjects with previously treated recurrent or metastatic…
- Conditions
- Carcinomas, Cervix Cancer, Cervical Cancer
- Trial name
- NCT05063916
- Testing
- AK104
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Urinary Retention (POUR)
Electroacupuncture on Postoperative Urinary Retention After Radical Surgery for Cervical Cancer
This is a prospective, blinded, single-center, randomized controlled trial. Investigators will include 208 patients with postoperative urinary retention (POUR) after radical hysterectomy for cervical cancer who have a clear…
- Trial name
- NCT07253194
- Testing
- EA intervention
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Lu Chao
Human Papillomavirus (HPV)-Related Cervical Cancer, HPV DNA
Clinical Trial Comparing the Self-test for Cervicovaginal Sample Versus Samples From Service Provider (Xyto-Ro)
Problem Description When cervical cancer screening is needed, the Pap test (or Pap smears) is still the most common, although there are challenges that continue to prevent effective screening services in many countries, poor…
- Trial name
- Xyto-Ro (NCT04520464)
- Testing
- Cervical samples for identification of HR-HPV DNA via real-time PCTR.
- Where
- Mexico
- Volunteers
- 444 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Hepatitis B, Human Papilloma Virus
Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health.
Aim: The main goal of this quantitative epidemiological observational study is to determine the prevalence of Human Papilloma Virus (HPV) infection and Hepatitis B (Hep B) immunity amongst women of childbearing age.
- Conditions
- Hepatitis B, Human Papilloma Virus, Mental Health Issue, Cancer Liver
- Trial name
- NCT06786429
- Testing
- Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy
- Volunteers
- 2,140 people, healthy volunteers welcome
- Sponsor
- Eunice Dube
Cervical Cancer
German-funded Laparoscopic Approach to Cervical Cancer
The G-LACC trial is a prospective, interventional, multicenter, open-label, randomized and controlled non-inferiority operative trial.
- Trial name
- G-LACC (NCT06489795)
- Testing
- Laparoscopic or robot-assisted radical/simple hysterectomy, Abdominal radical/simple hysterectomy
- Where
- 14 sites in Germany
- Volunteers
- 756 people
- Sponsor
- Hannover Medical School
Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer
Validation of a Nutrition Screening Tool
The objective of this study is to evaluate the sensitivity and specificity of two nutrition screening tools to identify inpatients with malnutrition or at risk of malnutrition.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Cervical Cancer, Endometrial Cancer, Esophageal Cancer
- Trial name
- NCT01851928
- Where
- United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Gynecologic Cancer, Cancer Metastatic
Study of AK112 in the Treatment of Advanced Gynecological Tumors
A phase II study to evaluate the efficacy and safety of AK112 in subjects with advanced gynecological tumors.
- Conditions
- Gynecologic Cancer, Cancer Metastatic, Ovarian Neoplasms, Cervical Neoplasm
- Trial name
- NCT04870177
- Testing
- AK112
- Where
- 2 sites in China
- Volunteers
- 53 people
- Sponsor
- Akeso
Cervical Cancer
Pilot Study for Speculum Free Cervical Cancer Screening
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- Calla (NCT04107181)
- Testing
- Introducer "calla" device, Interviews only
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Cancer, Venous Thromboembolism
People's Hospital of Xinjiang Uygur Autonomous Region
Objective: To evaluate the impact of enhanced recovery after surgery (ERAS)-based nursing intervention on venous thromboembolism (VTE) and lymphedema after radical hysterectomy for cervical cancer.
- Conditions
- Cervical Cancer, Venous Thromboembolism, Lymphedema
- Trial name
- NCT07612865
- Testing
- ERAS group
- Where
- China
- Volunteers
- 160 people
- Sponsor
- People's Hospital of Xinjiang Uygur Autonomous Region
Carcinoma, Non-Small-Cell Lung, Mesothelioma
Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors
This study will determine the maximum-tolerated dose (MTD) for oral bosutinib when used in combination with pemetrexed. The MTD is the highest dose of bosutinib with pemetrexed that can be given without causing severe side…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Mesothelioma, Bladder Cancer, Ovarian Cancer
- Trial name
- NCT03023319
- Testing
- Bosutinib, Pemetrexed
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nagla Abdel Karim
HPV Infection, Lesion Cervix
Investigation to Evaluate PAPILOCARE® Gel Effect on Normalization of Cervix Cytological Alterations Caused by HPV.
Observational clinical study, national, multicentric, prospective, non-comparative, with medical device, under application consistent with CE marking, for the evaluation of Papilocare® effectivness in the normalization of cervix…
- Trial name
- PAPILOBS (NCT04199260)
- Testing
- papilocare vaginal gel
- Where
- 9 sites in Spain
- Volunteers
- 263 people
- Sponsor
- Procare Health Iberia S.L.
Cervical Cancer, Endometrial Cancer
Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Vaginal Cancer
- Trial name
- NCT00118300
- Testing
- capecitabine, brachytherapy, radiation therapy
- Where
- 2 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Cervical Cancer, Vulvar Cancer
Survey on Lymphedema After Sentinel Lymph Node Biopsy in People With Cervical or Vulvar Cancer
The purpose of this study is to collect information that may identify people who are at risk of developing lower extremity lymphedema (LEL) after sentinel lymph node biopsy (SLN) during surgery for early-stage vulvar or cervical…
- Trial name
- NCT05255393
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
HPV16 Associated Cervical Cancer
Safety and Feasibility of TA-CIN Vaccine in HPV16 Associated Cervical Cancer
This study will be looking at what dose of the TA-CIN vaccine is safe and effective in patients with a history of HPV16-associated cervical cancer.
- Trial name
- NCT02405221
- Testing
- TA-CIN (arm), TA-CIN (thigh)
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Uterine Cervical Neoplasms
First-in-human (FIH) Phase I Trial of BS-006 in Cervical Cancer
This is a two-stage phase I clinical trial with oncolytic viruses BS-006 in recurrent or metastasis cervical cancer patients who failed in second line treatment.
- Trial name
- CC-OV01 (NCT05393440)
- Testing
- BS-006
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhongnan Hospital
Peripheral Neuropathy, Cervical Cancer
Exploring the Effects of Hand and Foot Exercise Intervention in Older Adults With Gynecological Cancer Receiving Chemotherapy Improvement of Peripheral Neuropathy and Quality of Life
Paclitaxel-based drugs are commonly used adjuvant chemotherapy for gynecological cancer patients. Peripheral neuropathy, a side effect of this treatment, presents with symptoms such as numbness, tingling, decreased skin and…
- Conditions
- Peripheral Neuropathy, Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT07362147
- Testing
- hand and foot exercises
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Advanced Cervical Cancer
Combination Therapy for First Line Treatment of Advanced Cervical Cancer
This is a single center phase 1 trail to observe safety and efficacy of Paclitaxel plus Cisplatin\Carboplatin, PD-L1 antibody Toripalimab and Anlotinib as first-line regimen to treat the patient with metastatic 、persistent or…
- Trial name
- NCT04731038
- Testing
- Anlotinib, Toripalimab, Paclitaxel, Cisplatin/ Carboplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital