Clinical trials: Cervix Uteri-Diseases
Lung Neoplasms, Ovarian Neoplasms
Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer
The purpose of this study is three-fold: 1) to examine the ability of the experimental drug tariquidar to improve chemotherapy results by blocking a protein (P-glycoprotein) on some cancer cells that acts to pump out cancer…
- Conditions
- Lung Neoplasms, Ovarian Neoplasms, Cervix Neoplasms, Renal Neoplasms
- Trial name
- NCT00069160
- Testing
- docetaxel, tariquidar, 99mTc-sestamibi imaging
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Carcinoma Cervix
Concurrent Chemoradiotherapy With Weekly Cisplatin Versus Concurrent Chemoradiotherapy With Weekly Cisplatin and Paclitaxel in Locally Advanced Carcinoma Cervix
The purpose of this study is to check whether addition of paclitaxel to cisplatin and radiation therapy will improve the outcome in locally advanced carcinoma cervix.
- Trial name
- NCT01593306
- Testing
- Paclitaxel, Cisplatin, Cisplatin
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Indira Gandhi Medical College, Shimla
Cervical Cancer
Study of Adjuvant Topotecan and Cisplatin With Concurrent Radiation Therapy for Advanced Cervical Cancer
A Phase I Study of Adjuvant Topotecan and Cisplatin with Concurrent Radiation Therapy for Advanced Cervical Cancer.
- Trial name
- NCT00320983
- Testing
- Topotecan, Cisplatin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of New Mexico
Human Papillomavirus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System
The purpose of this study is to provide data on the performance of the APTIMA HPV Assay using the TIGRIS System in detecting HPV types that may cause cervical cancer.
- Trial name
- NCT00973362
- Testing
- APTIMA HPV Assay, FDA-Approved HPV DNA Test
- Where
- 17 sites in United States
- Volunteers
- 12,896 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Cervical Cancer
Long-Term Follow-Up of HPV FOCAL Participants
This FOCAL follow-up study aims to assess the long-term effectiveness and safety of primary HPV testing for cervical cancer screening.
- Trial name
- HPV FOCAL (NCT04185389)
- Testing
- HPV and cytology co-testing (via Liquid based collection device)
- Where
- Canada
- Volunteers
- 1,710 people
- Sponsor
- University of British Columbia
Uterine Cancer, Cervical Cancer
Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix
Proton beam radiation therapy is known to spare surrounding normal tissues from radiation. Proton beam radiation delivers less radiation beyond the area of the target tissues.
- Trial name
- NCT01600040
- Testing
- Proton radiation therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Cancer of the Cervix, Cancer of the Endometrium
Real Time In-Vivo Dosimetry For Gynecologic Brachytherapy
This is an observational study. The purpose is to determine the feasibility of using a novel nano-scintillator fiber-optic dosimeter (nanoFOD) for the real time dosimetric monitoring of brachytherapy treatment.
- Trial name
- NCT02040155
- Testing
- Novel nano-scintillator fiber-optic dosimeter (nanoFOD)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Cervix Cancer
CAmpto-CISplatine Plus Radiotherapy in Advanced Cervix Cancer : Search of Tolerated Maximum Dose of Campto
Search of maximum tolerated irinotecan dose in association with cisplatin and pelvic radiotherapy in patients with an advanced cervix cancer.
- Trial name
- NCT00251888
- Testing
- campto (irinotecan), cisplatin (cisplatyl)
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- ARCAGY/ GINECO GROUP
Cervical Cancer
Pemetrexed and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00691301
- Testing
- cisplatin, pemetrexed disodium
- Where
- 12 sites in United States
- Volunteers
- 55 people
- Sponsor
- Gynecologic Oncology Group
Atypical Squamous Cells of Undetermined Significance, Cervical Cancer
SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells
This randomized phase II trial is studying how well SGN-00101 vaccine works compared to a placebo in treating human papillomavirus and preventing cervical cancer in patients with abnormal cervical cells.
- Conditions
- Atypical Squamous Cells of Undetermined Significance, Cervical Cancer, High-grade Squamous Intraepithelial Lesion, Low-grade Squamous Intraepithelial Lesion
- Trial name
- NCT00091130
- Testing
- HspE7, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer
Surgery With or Without Chemotherapy in Treating Patients With Stage IB Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00002536
- Testing
- cisplatin, vincristine sulfate, surgical procedure
- Where
- 41 sites in United States
- Sponsor
- Gynecologic Oncology Group
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
HPV, High-risk HPV (Any Strain)
Study Assessing Reduced HPV Infectivity and Transmission in HPV-Positive Women Following Vaccination With 9vHPV
This is a randomized, open-label trial, to assess whether a single dose of HPV nonavalent vaccine, administered to HIV uninfected, unvaccinated women with high risk HPV16/18/31/33/45/52 or 58 can decrease the infectivity of shed…
- Conditions
- HPV, High-risk HPV (Any Strain), Human Papillomavirus (HPV) Infections
- Trial name
- RIFT-SSA (NCT07303751)
- Testing
- Nonavalent HPV vaccine (9vHPV)
- Where
- Sierra Leone
- Volunteers
- 80 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Cancer, Cervical, Recurrence
Retrospective Cervical Cancer Oligo States (Recurrence, Metastasis) Multicentre Outcomes Study
This multi centric international retrospective study aims to register patients with oligo metastatic and oligo recurrent cervical cancer.
- Conditions
- Cancer, Cervical, Recurrence, Metastasis
- Trial name
- Retro-COSMOS (NCT06150222)
- Testing
- Concurrent Chemoradiation, Systemic Chemotherapy other locally directed therapies (like surgery, ablation, etc.)
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
Cervix Neoplasms, Uterine Neoplasms
Intensity Modulated Radiation Therapy - Gyne Cancer (GY03.2)
Standard treatment for gynecological cancer is radiation therapy in two phases; whole pelvic radiation and then an internal radiation boost, also called a brachytherapy boost, to treat any remaining tumour.
- Conditions
- Cervix Neoplasms, Uterine Neoplasms, Vaginal Neoplasms
- Trial name
- NCT00188578
- Testing
- Intensity Modulated Radiation Therapy Boost
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Cervical Cancer
Fluorine F 18 EF5 PET/CT Imaging in Patients With Locally Advanced or Recurrent/Metastatic Cervical Cancer
RATIONALE: Diagnostic procedures, such as fluorine F 18 EF5 PET/CT imaging, may help find oxygen in tumor cells. It may also help doctors predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00978874
- Testing
- fludeoxyglucose F 18, fluorine F 18 EF5
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cancer Cervix
Vaginal Self-sampling and Human Papillomavirus Testing in Unscreened Women
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-3 (NCT02255084)
- Testing
- Group 1 remove self sample kit at gp consulting room or perform pap smear, Group 2 perform self sample at home or pap smear
- Where
- France
- Volunteers
- 3,612 people
- Sponsor
- University Hospital, Tours
Breast Cancer, Lung Cancer
The Effectiveness of the Screening Inventory of Psychosocial Problems (SIPP) in Cancer Patients
The purpose of this study is to evaluate the effectiveness and feasibility of the Screening Inventory of Psychosocial Problems (SIPP) in consultation settings with respect to early recognition and treatment of psychosocial…
- Conditions
- Breast Cancer, Lung Cancer, Prostate Cancer, Bladder Cancer
- Trial name
- NCT00859768
- Testing
- Questionnaire administration
- Where
- Netherlands
- Volunteers
- 568 people
- Sponsor
- Netherlands Open University
Cervical Incompetence
Cervical Occlusion Double-level Stitch Application
Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes…
- Trial name
- COSA (NCT05268640)
- Testing
- Double-level cervical cerclage, Single-level cervical cerclage
- Where
- 7 sites in Poland
- Volunteers
- 81 people
- Sponsor
- Centre of Postgraduate Medical Education
Cervical Cancer Squamous Cell
MRI FDG PET Imaging Cervix
The standard treatment for cervix cancer at Princess Margaret Hospital is external radiation with chemotherapy followed by internal radiation, called brachytherapy.
- Trial name
- NCT01899404
- Testing
- 18-FDG PET/CT, DWI, DCE-MRI
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto