Clinical trials: Cervix Uteri-Diseases
Carcinoma Cervix
Study on Early Stage Bulky Cervical Cancers
The aim of this study is to establish the role of neoadjuvant chemotherapy and chemo irradiation in carcinoma cervix and to compare its results with the concurrent chemo irradiation in terms of overall survival, disease free…
- Trial name
- NCT01917695
- Testing
- Chemotherapy, External Beam Radiotherapy, Brachytherapy
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Rajkumar Kottayasamy Seenivasagam
Cervical Cancer, Endometrial Cancer
Bevacizumab and Rucaparib in Recurrent Carcinoma of the Cervix or Endometrium
This is a phase II study of rucaparib, a small molecule inhibitor poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP), being tested in combination with bevacizumab in patients with recurrent cervical or endometrial…
- Trial name
- Clovis-001 (NCT03476798)
- Testing
- Rucaparib, Bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Oklahoma
Cancer, All Types, Cancer of Liver
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
The PIONEER Initiative stands for Precision Insights On N-of-1 Ex vivo Effectiveness Research. The PIONEER Initiative is designed to provide access to functional precision medicine to any cancer patient with any tumor at any…
- Conditions
- Cancer, All Types, Cancer of Liver, Cancer of Stomach, Cancer of Head and Neck
- Trial name
- PIONEER (NCT03896958)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- SpeciCare
Cervical Dysplasia
Digital Imaging Aid for Assessment of Cervical Dysplasia
The overall objective of this study is to evaluate whether polarized or green filtered digital imaging can assist clinicians to screen for premalignant lesions in the cervix.
- Trial name
- NCT00511758
- Testing
- Digital Imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Cervical Intraepithelial Neoplasia
Topical Imiquimod vs. LEEP for Women With Carcinoma In-situ of the Cervix
OBJECTIVE: The standard of care for high grade cervical intraepithelial neoplasia grade 2 to 3 (CIN 2-3) has been the excision of the cervical transformation zone by way of a loop electrosurgical excision procedure (LEEP) or cold…
- Trial name
- NCT02130323
- Testing
- Imiquimod, Loop Electrosurgical Excision Procedure
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Medical Education, Ovarian Cancer
Ultrasound Training Program for Gynecologic Cancer Staging in Residents
This is a prospective, interventional study aiming to develop and validate an ultrasound training program for gynecology and obstetrics residents, focused on the staging of gynecologic cancers, including ovarian, endometrial, and…
- Conditions
- Medical Education, Ovarian Cancer, Endometrial Cancer, Cervix Cancer
- Trial name
- Ultra-teaching (NCT07028229)
- Testing
- Training Group
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervix Cancer, Cervical Cancer
Neoadjuvant Chemotherapy in Cervical Cancer
Cervical cancer represents the second commonest cancer in women worldwide, with 500,000 new cases and 300,000 deaths reported yearly.
- Conditions
- Cervix Cancer, Cervical Cancer, Cancer of the Uterine Cervix
- Trial name
- NCT05384366
- Testing
- Neoadjuvant chemotherapy
- Where
- India
- Volunteers
- 33 people
- Sponsor
- Banaras Hindu University
Cervical Cancer
Neoadjuvant Bevacizumab and Carboplatin Followed by Concurrent Bevacizumab, Carboplatin and Radiotherapy in the Primary Treatment of Cervix Cancer
This trial is designed to study the safety and efficacy of the combination of carboplatin, bevacizumab, and pelvic radiation therapy.
- Trial name
- NCT00600210
- Testing
- Bevacizumab, Carboplatin, Radiation Therapy
- Where
- United States
- Sponsor
- Leo W. Jenkins Cancer Center
Cervix Cancer
Megavoltage CT (MVCT) Imaging for Intracavitary Radiation Treatment in Cervix Cancer
The Cross Cancer Institute has recently acquired a tomotherapy radiotherapy treatment machine; the first of its kind in Canada. It has the potential to improve cancer treatment outcomes where radiotherapy is used.
- Trial name
- NCT00124423
- Testing
- Megavoltage CT scan
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- AHS Cancer Control Alberta
Cervix Cancer
Impact of Erythropoietin Administration During Definitive Cervix Cancer Radiotherapy on Treatment Outcome
The purpose of this study is to determine whether an increase of blood haemoglobin levels through the substitution of erythropoietin during radiotherapy treatment of cervix cancer patients results in improvement for disease…
- Trial name
- NCT00348738
- Testing
- Erythropoietin
- Where
- 4 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
HIV Infections
Safety and Acceptability of the Anti-Microbe Vaginal Gel, PMPA Gel
The purpose of this study is to evaluate the PMPA gel, which kills microbes, in HIV-infected and HIV-uninfected women. The majority of new HIV infections occur through heterosexual contact.
- Trial name
- NCT00028132
- Testing
- Tenofovir
- Where
- 5 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cervical Cancer
Laparoscopic Approach to Cervical Cancer
The goal of this clinical research study is to compare the long-term outcomes of different surgical methods for the treatment of cervical cancer.
- Trial name
- LACC (NCT00614211)
- Testing
- Total Abdominal Radical Hysterectomy, Total Laparoscopic or Robotic Radical Hysterectomy
- Where
- 33 sites in United States, Argentina and 11 more
- Volunteers
- 636 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Prostate Cancer, Glioblastoma
MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy)
The MRI linac Unity is a major technological evolution in radiotherapy combining a linear accelerator with a 1.5T MRI (radiological quality).
- Conditions
- Prostate Cancer, Glioblastoma, Head and Neck Cancer, Kidney Cancer
- Trial name
- ISRAR (NCT06041555)
- Testing
- 3 MRI sequences (T2*, IVIM and Multi Echo-Gradient), without injection, are performed
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Cervical Cancer
Immunotherapy of Cervical Cancer With V3-Cervix
The goal of this trial is to evaluate the efficacy of immunotherapy for cervical cancer based on a fundamentally new approach. We will test new tableted preparation, V3-Cervix, obtained from hydrolyzed, inactivated blood and…
- Trial name
- V3-Cervix (NCT03550755)
- Testing
- V3-Cervix
- Where
- Mongolia
- Volunteers
- 20 people
- Sponsor
- Immunitor LLC
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Cancer of Ovary, Endometrium Cancer
The Effect of Logotherapy on Mental Health in Gynecological Cancer Patients
Gynecological cancers negatively affect women's sexuality, fertility, body image, and self-perception, resulting in deterioration in their psychological health.
- Conditions
- Cancer of Ovary, Endometrium Cancer, Cervix Cancer
- Trial name
- NCT05246462
- Testing
- Logotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cervix Cancer
Validation of the Genetic Signature 354849 as a Prognostic Method
This prospective study is focused on the validation of the genetic signature of 27 genes as a predictor of the response to concomitant chemotherapy treatment followed by brachytherapy in patients with locally advanced cervical…
- Trial name
- NCT04067882
- Testing
- Genetic signature
- Where
- 2 sites in Mexico
- Volunteers
- 189 people
- Sponsor
- National Institute of Cancerología
Cancer of the Cervix
Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients
The researchers plan: To undertake clinical studies of radiotherapy with or without the administration of the chemotherapeutic agent cisplatin, known to be a radiosensitizer; To perform pre-clinical studies of the…
- Trial name
- NCT00122746
- Testing
- Radiotherapy alone, Radiotherapy with cisplatin
- Where
- 5 sites in India, South Africa and 3 more
- Volunteers
- 322 people
- Sponsor
- International Atomic Energy Agency
Cancer of Cervix, Ovarian Cancer
The Assessment of Preoperative Psychological Intervention on Stress in Women With Gynecological Malignancies
The purpose of this study is to asses the impact of a tailored preoperative psychological intervention on women with gynecological malignancies on psychological, physiological and immunological parameters
- Conditions
- Cancer of Cervix, Ovarian Cancer, Cancer of Endometrium
- Trial name
- NCT00726635
- Testing
- Cognitive intervention, Control group, psycho-physiological intervention
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center