Clinical trials: Cesarean Delivery, open to volunteers
Cesarean Delivery
Post-Operative Cesarean Section Cosmesis
Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Several recent reviews have summarized the evidence for various steps of cesarean delivery, but…
- Trial name
- NCT06412978
- Testing
- absorbable subcuticular polyglycolic acid staples (INSORB), subcuticular, polyglecaprone suture (Monocryl)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypotension, Spinal Anesthesia
Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT07678723
- Testing
- Not applicable- observational study
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Cesarean Delivery
A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China
The investigators are committed to identifying the optimal timing of delivery for low-risk pregnancies. While current guidelines typically recommend induction at 41 weeks, emerging evidence suggests that elective induction at 39…
- Trial name
- LIRIC (NCT07082530)
- Testing
- Labor Induction at 39 Weeks, Expectant management
- Where
- China
- Volunteers
- 1,074 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Elective Cesarean Delivery
Development of a Patient-Centered Assessment Tool for Pain During Cesarean Delivery
This study aims to develop a standardized tool to assess intraoperative pain during cesarean delivery under neuroaxial anesthesia.
- Trial name
- NCT07409012
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Elective Cesarean Delivery
Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery
Postpartum hemorrhage (PPH) is the leading cause of death related to pregnancy. PPH can lead to blood transfusion, disseminated intravascular coagulation (DIC), hysterectomy, or death.
- Trial name
- NCT06235749
- Testing
- Calcium Gluconate 10%, sodium chloride 0.9%
- Where
- 4 sites in Israel
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Cesarean Delivery, General Anesthesia
The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry
The SOAP registry is a prospective, multicenter, electronic registry. The goal is to investigate the indications, mode of airway management, predisposing factors, and obstetric and anesthetic outcomes of pregnant patients who…
- Trial name
- NCT06030063
- Where
- 35 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Obstetrical Complications, Labor and Delivery Complication
Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial
This is a phase-III multi-center double-blind randomized controlled trial of 8,000 individuals undergoing a scheduled or prelabor cesarean delivery who are randomized to either adjunctive azithromycin prophylaxis or to placebo.
- Conditions
- Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery
- Trial name
- PRECEDE (NCT06605118)
- Testing
- Azithromycin Injection, Standard of Care Preoperative antibiotics
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Spinal Induced Hypotension in Cesarean Delivery
Minimum Effective Volume of Crystalloid Co-Loading to Prevent Spinal Anesthesia-Induced Hypotension in Cesarean Section
The goal of this clinical trial is to find the minimum effective volume of IV crystalloid that should be given with phenylephrine to prevent hypotension caused by spinal anesthesia in healthy, term pregnant adults having elective…
- Trial name
- NCT07324512
- Testing
- Intravenous Crystalloid Co-Loading
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Infant, Newborn, Gut -Microbiota
Infant Microbiota Restoration With Maternal Microbes
The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants.
- Conditions
- Infant, Newborn, Gut -Microbiota, Gut Dysbiosis, Cesarean Delivery Affecting Newborn
- Trial name
- MaMi (NCT07212361)
- Testing
- Probiotic
- Where
- 2 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Cesarean Delivery Affecting Fetus, Labor Dystocia
Early Diagnosis and Intervention for Fetal Malposition in Active Labor and Its Impact on Mode of Delivery
The goal of this randomized trial is to test if changing a person's position in labor can increase the chances of delivering their baby vaginally.
- Conditions
- Cesarean Delivery Affecting Fetus, Labor Dystocia, Labor Complication
- Trial name
- NCT05881629
- Testing
- Maternal position change to side-lying lateral with peanut ball, Free maternal position
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Postoperative Pain, Cesarean Delivery
Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial
The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section.
- Conditions
- Postoperative Pain, Cesarean Delivery, Analgesia, Obstetrical
- Trial name
- NCT07094802
- Testing
- Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Pregnant Women Undergoing Cesarean Delivery
Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section
The purpose of this study is to asses the effect of preoperative prophylactic intravenous tranexamic acid on perioperative blood loss in pregnant women undergoing cesarean section
- Trial name
- NCT07078942
- Testing
- Tranexamic Acid
- Where
- Thailand
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Site Infection, Cesarean Section; Complications, Wound, Infection (Following Delivery)
Vaginal Microbiota and Post-cesarean SSI
The goal of this observational study is to investigate the relationship between vaginal microbiota composition and the development of post-cesarean section wound infection in women undergoing cesarean delivery.
- Trial name
- NCT06840041
- Testing
- Vaginal swab and culture
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Cesarean Delivery Affecting Newborn, Obesity, Childhood
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham.
- Conditions
- Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome, Microbiota
- Trial name
- NCT03298334
- Testing
- Vaginal Seeding, No Vaginal Seeding
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Postspinal Hypotension, Pregnant Women Undergoing Cesarean Delivery
Carotid Flow Measurements in Pregnant Women
The goal of this observational study is to reveal the relation between carotid flow changes and post-spinal hypotension in pregnant women between the ages of 20-40.
- Trial name
- NCT06813989
- Testing
- carotid ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Delivery, Obstetric, Cesarean Section
Comparison Between Two Medical Devices for Labor Induction After Previous C-section
The objective of the study ist to compare the Dilapan-S and the Cook Ballon device for the mechanical induction of labour in women with a previous C-section.
- Conditions
- Delivery, Obstetric, Cesarean Section, Obstetric Delivery
- Trial name
- DiBal (NCT06506721)
- Testing
- Double ballon device, Cook, Hygroscopic cervix dilators, Dilapan-S
- Where
- Switzerland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Delivery Complication, Cesarean Delivery Affecting Fetus
Time of Oxytocin Initiation at 2nd Stage of Labor and Adverse Outcomes
Early oxytocin administration at the 2nd stage of labor is associated with a higher rate of vaginal delivery, shorter second stage duration, and fewer adverse maternal and neonatal outcomes.
- Trial name
- NCT06181396
- Testing
- Oxytocin
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus