Clinical trials: Cesarean Delivery, active
Cesarean Delivery
Post-Operative Cesarean Section Cosmesis
Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Several recent reviews have summarized the evidence for various steps of cesarean delivery, but…
- Trial name
- NCT06412978
- Testing
- absorbable subcuticular polyglycolic acid staples (INSORB), subcuticular, polyglecaprone suture (Monocryl)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Complex Obstetric Surgery, Perioperative Pain Management
COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block
To assess the effect of intraoperative transversus abdominis plane (TAP) blocks on the amount of opioid pain medications expressed as morphine milliequivalents (MME) used postoperatively in patients who have undergone cesarean…
- Conditions
- Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
- Trial name
- COMFORT (NCT06925152)
- Testing
- Bupivicaine intervention arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Tennessee
Hypotension During Cesarean Delivery, Blood Pressure Monitoring
Comparison of HPI-guided Norepinephrine Boluses, ClearSight-guided Norepinephrine Infusion, and Oscillometric-guided Norepinephrine Infusion for Blood Pressure Stability During Cesarean Delivery
Background: Post-spinal hypotension occurs in 50-80% of cesarean deliveries and causes maternal nausea, vomiting, and reduced neonatal vigor; norepinephrine (NE), as boluses or prophylactic infusion, is the mainstay of treatment.
- Trial name
- NCT07883265
- Testing
- Hypotension Prediction Index derived from the noninvasive arterial waveform, Continuous noninvasive arterial pressure monitoring (HPI blinded), Norepinephrine intermittent bolus
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Hypotension, Spinal Anesthesia
Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT07678723
- Testing
- Not applicable- observational study
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Cesarean Delivery
BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)
In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.
- Trial name
- NCT07786012
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Postoperative Pain After Cesarean Delivery
LI4 and SP6 Acupuncture for Pain After Cesarean Delivery
This randomized, sham-controlled clinical trial will evaluate the effectiveness of acupuncture at bilateral LI4 and SP6 as an adjunct to standard postoperative analgesia for acute pain after cesarean delivery.
- Trial name
- NCT07869589
- Testing
- Bilateral Acupuncture Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Nigde Omer Halisdemir University
Cesarean Delivery
Cesarean Anesthesia Blood Gas
This prospective observational cohort study will evaluate maternal and fetal blood gas parameters in women undergoing cesarean delivery under spinal or general anesthesia.
- Trial name
- NCT07861633
- Testing
- Anesthesia Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Bagcilar Training and Research Hospital
Cesarean Delivery
IC-CS Risk: Patient Outcomes
This study is looking at the impact of the implementation of a cesarean risk calculator on cesarean delivery and maternal morbidity rates.
- Trial name
- NCT06488092
- Testing
- Cesarean Risk Calculator
- Where
- 14 sites in United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Postoperative Analgesia After Cesarean Delivery
Ultrasound-Guided Posterior Quadratus Lumborum Block With Bupivacaine and Dexmedetomidine Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Delivery
Cesarean delivery (CD) is one of the most commonly performed surgical procedures worldwide, with millions of women undergoing the procedure annually (1).
- Trial name
- NCT07807592
- Testing
- Intrathecal Morphine, Ultrasound-Guided Posterior Quadratus Lumborum Block
- Volunteers
- 80 people
- Sponsor
- Assiut University
Labor Induction, Cesarean Delivery
Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin
A randomized trial of patients undergoing a term (≥37 weeks) induction of labor with a history of one prior Cesarean delivery, wherein the provider intends to use a Foley catheter for cervical ripening.
- Trial name
- LIFT (NCT07006896)
- Testing
- Foley balloon, Oxytocin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Maternal Anxiety, Cesarean Delivery
Restrained vs Gripping String Techniques in Patients Undergoing Cesarean Delivery
This randomized controlled trial will compare two upper-extremity restraint techniques in patients undergoing elective cesarean delivery under neuraxial anesthesia.
- Trial name
- NCT07772219
- Testing
- Standard Forearm Restraint, Wrist-Level Gripping Restraint
- Where
- United States
- Volunteers
- 272 people
- Sponsor
- Ohio State University
Pregnancy, Cesarean Delivery
Comparison of Non-Invasive Mean Arterial Blood Pressure Measurements at the Arm and Ankle During Elective Cesarean Delivery.
This observational study aims to compare mean arterial pressure measurements obtained using an ankle blood pressure cuff with those obtained using a standard upper-arm cuff in pregnant individuals undergoing elective cesarean…
- Conditions
- Pregnancy, Cesarean Delivery, Blood Pressure Measurement in Pregnancy, Skin to Skin Contact
- Trial name
- NCT07422766
- Testing
- Mean arterial pressure
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- St. Justine's Hospital
Cesarean Delivery
A RCT of Labor Induction at 39 Weeks in Low - Risk Women in China
The investigators are committed to identifying the optimal timing of delivery for low-risk pregnancies. While current guidelines typically recommend induction at 41 weeks, emerging evidence suggests that elective induction at 39…
- Trial name
- LIRIC (NCT07082530)
- Testing
- Labor Induction at 39 Weeks, Expectant management
- Where
- China
- Volunteers
- 1,074 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Elective Cesarean Delivery
Development of a Patient-Centered Assessment Tool for Pain During Cesarean Delivery
This study aims to develop a standardized tool to assess intraoperative pain during cesarean delivery under neuroaxial anesthesia.
- Trial name
- NCT07409012
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cesarean Delivery
An Observational Study Measuring in a Non-invasive Approach the Nociception Level Index and Its Association With Pain and Anxieiy Perception Evaluated by Questionnaires, in Awake Women During Elective Cesarean Delivery Under Spinal Anesthesiaanxiety
The Nociception Level (NOL) Index is a multiparametric, non-invasive monitor that objectively assesses nociception by integrating several autonomic physiological signals.
- Trial name
- NCT07726316
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Michael Grach
Elective Cesarean Delivery
Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery
Postpartum hemorrhage (PPH) is the leading cause of death related to pregnancy. PPH can lead to blood transfusion, disseminated intravascular coagulation (DIC), hysterectomy, or death.
- Trial name
- NCT06235749
- Testing
- Calcium Gluconate 10%, sodium chloride 0.9%
- Where
- 4 sites in Israel
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Hearing Loss; Post-Dural Puncture Headache; Cesarean Delivery
Evaluation of Postoperative Hearing Loss After Spinal Anesthesia for Elective Cesarean Section in Pregnant Women
This prospective observational study will evaluate postoperative hearing changes in women undergoing elective cesarean delivery under spinal anesthesia.
- Trial name
- NCT07697651
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Duzce University
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Cesarean Section, Delivery; Trauma
Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after…
- Trial name
- EAGLET-CS (NCT07334418)
- Testing
- General anesthetic, Intravenous anesthetic
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania