Clinical trials: Cesarean Delivery Procedures
Acute Pain, Cesarean Delivery
NSS-Bridge Device for Post-Cesarean Delivery Pain
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Trial name
- NCT03830307
- Testing
- NSS-2-Bridge
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Pregnant Women, Pain
Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block.
- Conditions
- Pregnant Women, Pain, Hypotension
- Trial name
- NCT02973048
- Testing
- Hyperbaric bupivacaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Drying Time
Chlorhexidine Drying Time
Before a patient gets a spinal/epidural, their lower back is cleaned with an antiseptic solution diluted in alcohol called ChloraPrep. ChloraPrep must completely dry before starting the anesthetic procedure.
- Trial name
- Chlorhexidine (NCT02095535)
- Testing
- Chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Operative Time, Wound Heal
Subcuticular Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery
Despite the high numbers of cesareans being performed, scientific evidence behind which surgical techniques are best remains uncertain.
- Trial name
- NCT05112640
- Testing
- INSORB: subcuticular stapling device, Subcuticular monocryl suture manufactured by Ethicon
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Major Puerperal Infection, Postpartum, Wound Complications
Negative Pressure Wound Therapy After Cesarean Delivery
This study is aimed at determining whether or not the use of a wound suction device placed on the cesarean incision instead of a standard sterile dressing will decrease the prevalence of wound complications and wound infections…
- Conditions
- Major Puerperal Infection, Postpartum, Wound Complications, Wound Seroma, Caesarean Section Wound Separation
- Trial name
- NCT01637870
- Testing
- Prevena negative pressure wound system
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Abbey Hardy-Fairbanks
Hypotension During Cesarean Delivery, Spinal Anesthesia
Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia.
The purpose of the study is to learn more about how the heart works during cesarean delivery under spinal anesthesia (medicines given in the spine that numb parts of your body to block pain) in women.
- Trial name
- NCT01928797
- Testing
- Cardiac output monitor data
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Patient Satisfaction, Earlier Family Bond Initiation
Family-Centered Cesarean Delivery
The purpose of this study is to determine if patient birthing experiences differ between the family-centered and traditional cesarean methods.
- Conditions
- Patient Satisfaction, Earlier Family Bond Initiation, Maternal and Neonatal Outcomes
- Trial name
- FCC (NCT02690077)
- Testing
- Family-Centered Cesarean, Traditional Cesarean
- Where
- 2 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Surgical Wound Dehiscence, Wound Infection
Prevention of Wound Complications After Cesarean Delivery in Obese Women Utilizing Negative Pressure Wound Therapy
Wound complications after Cesarean section (C-section) are common in obese women. Approximately 25% of obese women having a C-section will have a wound complication.
- Trial name
- NCT00654641
- Testing
- Negative pressure wound closure, Standard wound closure
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- West Virginia University
Uterine Atony, Hypotension
Oxytocin And Uterotonic Agent Use For Cesarean Delivery
The central objective of this study will be to evaluate a standardized, evidence-based regimen versus a conventional regimen for uterotonic drug dosing for elective cesarean delivery The investigators primary hypothesis is that…
- Trial name
- NCT01549223
- Testing
- Oxytocin Infusion, Oxytocin Bolus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Persistent Pain After Delivery
Persistent Pain After CS Delivery
Many factors influence the development of persistent pain after CS (chronic pain) as well as post-partum depression. We are attempting to use trajectory pain methods in an attempt to identify those at risk for the development of…
- Trial name
- NCT01996592
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Morbid, Spinal Anesthesia
ED90 for Hyperbaric Bupivacaine in Super Obese Parturients
The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.
- Conditions
- Obesity, Morbid, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT03781388
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Pregnancy, Cesarean Section
Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide
Our objective is to compare gastric volumes (mL) between women who receive metoclopramide versus placebo prior to scheduled cesarean delivery in appropriately fasted patients.
- Conditions
- Pregnancy, Cesarean Section, Aspiration
- Trial name
- NCT05033041
- Testing
- Study drug metoclopramide
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Pregnancy, Cesarean Section
Comparison of Staples Versus Prolene Suture for Skin Closure at Cesarean Delivery
Currently different materials are used to close the skin after a cesarean delivery, including absorbable suture, non-absorbable suture and staples.
- Trial name
- NCT01509950
- Testing
- Staples, Prolene non-absorbable sutures, Absorbable Sutures
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Effects of; Anesthesia, in Pregnancy
Carbetocin Versus Oxytocin and Hemodynamic Effects
A randomized double-blind trial of oxytocin 5 u, carbetocin 100 µg and placebo with hemodynamic response as a primary outcome measure.
- Trial name
- NCT00977769
- Testing
- carbetocin 100 µg, oxytocin 5 u
- Where
- 2 sites in Norway
- Volunteers
- 76 people
- Sponsor
- Oslo University Hospital
Wound Complication, Complications; Cesarean Section
Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
The goal of this project is to identify a strategy to reduce wound complications in women who undergo cesarean delivery by Pfannenstiel skin incision.
- Trial name
- TASC (NCT02838017)
- Testing
- Tissue Adhesive, Sterile strips
- Where
- 3 sites in United States
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Postpartum Hemorrhage
Tranexamic Acid and Thromboelastography During Cesarean Delivery
The aim of this study is to characterize the coagulation changes, using thromboelastography (TEG), after prophylactic tranexamic administration during cesarean delivery.
- Trial name
- TA TEG (NCT02026297)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Cesarean Section Complications, Opioid Use
TENS and Opioid Use After Cesarean Delivery
We propose to explore the effects of Transcutaneous Electrical Nerve Stimulation (TENS) therapy in the pain management of postpartum women. A.
- Trial name
- NCT03843788
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Physiological Effect of Drugs, Morphine
Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine
The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for…
- Conditions
- Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid
- Trial name
- NCT04369950
- Testing
- 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Health Science Center, Houston