Clinical trials: Cesarean Section Surgery
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
D001458, D011247
Effect of Prophylactic Negative Pressure Versus Silver Impregnated Silicone Bandage on C-Section Infection Rates
Effect of Prophylactic Negative Pressure versus Silver Impregnated Silicone Bandage on Cesarean Section Surgical Site Infection Rate
- Trial name
- NCT04582045
- Testing
- silver impregnated dressing
- Where
- United States
- Volunteers
- 1,064 people
- Sponsor
- HealthPartners Institute
Surgical Anesthesia, Cesarean Section
Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Regional anesthesia is commonly used for elective and emergency cesarean delivery. It provides numerous safety advantages when compared to general anesthesia for both the mother and fetus1.
- Trial name
- NCT03414359
- Testing
- 2% Lidocaine, 3% Chloroprocaine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Surgery, Opioid Use
Opioid Prescribing After Cesarean Delivery
The number of opioid overdose deaths in the United States has quadrupled in 15 years, a dramatic manifestation of the current opioid abuse epidemic.
- Trial name
- NCT03168425
- Testing
- Tailored prescription, Control
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Surgical Site Infection Following Cesarean Delivery
Comparison of Surgical Skin Preps During Cesarean Deliveries
In women that undergo non-emergency cesarean delivery, we are comparing the skin preparation solutions for best outcome of surgical site infection.
- Trial name
- NCT01870583
- Testing
- Iodine povidone, Chlorhexidine, Combination iodine and chlorhexidine
- Where
- 2 sites in United States
- Volunteers
- 1,404 people
- Sponsor
- Montefiore Medical Center
Surgical Site Infections
The Skin Prep Study
The investigators propose a randomized controlled clinical trial to determine the comparative effectiveness of chlorhexidine-alcohol and iodine-alcohol preoperative skin preparation for preventing surgical site infections at…
- Trial name
- NCT01472549
- Testing
- Iodine-alcohol, Chlorhexidine-alcohol
- Where
- United States
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Wound
Staples Versus Suture for Cesarean Wound Closure
The objective of this randomized controlled trial is to compare wound morbidity (including disruption and infection) in surgical staples versus absorbable subcuticular suture for wound closure in cesarean deliveries.
- Trial name
- SVS (NCT01008449)
- Testing
- Surgical staples, Absorbable Surgical Suture
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Alabama at Birmingham
Negative Pressure Wound Therapy, Cesarean Section; Infection
The Invia Motion at Cesarean Study
To assess patient centered outcomes of the Medela INVIA Motion prophylactic NPWT system at cesarean delivery.
- Trial name
- NCT04365452
- Testing
- Invia Motion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Surgical Site Infection, Surgical Wound Infection
Antibacterial-coated Sutures at Time of Cesarean
Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections after a number of surgical procedures, but none of the previous trials included cesarean delivery.
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Cesarean Section; Infection, Cesarean Section Complications
- Trial name
- ASTC (NCT03386240)
- Testing
- Vicryl-plus, monocryl-plus, PDS-plus (Triclosan-coated Sutures), Vicryl, monocryl, PDS (not coated with triclosan)
- Where
- United States
- Volunteers
- 1,169 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Analgesia, Obstetrical, Obstetric Surgical Procedures
Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery
Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing.
- Trial name
- NCT02789410
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Surgical Wound
A Clinical Trial of Subcuticular Staples Versus Subcuticular Suture for Cesarean Section Skin Closure
Currently, the way doctors close the skin during cesarean section is different between surgeons and there is little evidence to support the use of one kind of closure over the other.
- Trial name
- NCT01753518
- Testing
- Subcuticular suture, Subcuticular staple
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Margaret L. Dow, M.D.
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Cesarean Section Complications, Wound Breakdown
Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery
This will be an open label pilot randomized controlled clinical trial. Women undergoing cesarean delivery will be randomized to have standard wound dressing care or chlorohexidine gluconate (CHG) impregnated wound dressing…
- Conditions
- Cesarean Section Complications, Wound Breakdown, Wound Infection, Satisfaction
- Trial name
- NCT03887299
- Testing
- ReliaTect™ Post-Op Dressing (contains chlorohexidine gluconate or CHG), Standard Wound Care
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cesarean Section
Cesarean Section Via Enhanced Recovery
Enhanced Recovery After Surgery (ERAS) protocols have been proven to be very successful in specific patient populations. An example is with ERAS for colorectal surgery.
- Trial name
- NCT03552822
- Testing
- ERAS Protocol Implementation
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cesarean Section, Endometritis
Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
The objective of the project is to find out whether cleansing the vagina before a cesarean delivery decreases the risk of complications and infections after having the baby.
- Conditions
- Cesarean Section, Endometritis, Surgical Wound Infection
- Trial name
- NCT00386477
- Testing
- Vaginal cleansing before cesarean delivery
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Cesarean Section
Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Cesarean delivery under general anesthesia is one of few only surgical procedures, where the most important factor of safety is the speed of the surgery, as a newborn adaptation strongly depends on a time between induction to the…
- Trial name
- NCT01941628
- Testing
- Rocuronium, Succinylcholine
- Where
- Czechia
- Volunteers
- 91 people
- Sponsor
- Charles University, Czech Republic
Post-operative Complications, Surgical Site Infection
The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions
The purpose of this study is to compare the post-surgical standard-of-care dressing to the Prevena™ Incision Management System in women undergoing Cesarean section surgery.
- Conditions
- Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
- Trial name
- NCT01450631
- Testing
- Prevena™ Incision Management System (PIMS), Standard-of-care Dressing
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- KCI USA, Inc
Obesity, Surgical Site Infections
Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery
The investigators aim to show that single use negative pressure dressings can decrease the rate of wound complications in obese women (BMI > 40 kg/m2) undergoing cesarean delivery at a tertiary medical center by randomizing women…
- Conditions
- Obesity, Surgical Site Infections, Wound Complications, Complications; Cesarean Section
- Trial name
- NCT02799667
- Testing
- Standard Dressing, Negative Pressure Wound Therapy Dressing
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Surgical Site Infection, Cosmetic Appearance of Cesarean Scar
Prospective Study on Cesarean Wound Outcomes
This study will investigate whether the placement of silver impregnated dressings beginning in the OR will improve wound healing in patients undergoing cesarean delivery compared to traditional Telfa pads.
- Conditions
- Surgical Site Infection, Cosmetic Appearance of Cesarean Scar, Post Operative Pain
- Trial name
- NCT01697748
- Testing
- Silver-impregnated dressing, Telfa pad dressing
- Where
- 3 sites in United States
- Volunteers
- 660 people
- Sponsor
- University of South Florida