Clinical trials: Cesarian Section
Adhesions, Cesarean Section
Seprafilm® Adhesion Barrier and Cesarean Delivery
A multicenter, randomized, controlled, single blinded study to evaluate the effectiveness of Seprafilm® Adhesion Barrier in reducing adhesion formation in cesarean deliveries.
- Conditions
- Adhesions, Cesarean Section, Delivery, Obstetric
- Trial name
- NCT00565643
- Testing
- modified sodium hyaluronic acid and carboxymethylcellulose
- Where
- 3 sites in United States
- Volunteers
- 753 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Drying Time
Chlorhexidine Drying Time
Before a patient gets a spinal/epidural, their lower back is cleaned with an antiseptic solution diluted in alcohol called ChloraPrep. ChloraPrep must completely dry before starting the anesthetic procedure.
- Trial name
- Chlorhexidine (NCT02095535)
- Testing
- Chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cesarean Section, Surgical Site Infection
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
Surgical site infections (SSI) are the second most common cause of nosocomial infections accounting for 15% of all nosocomial infections among hospitalized patients and 38% of nosocomial infections in surgical patients.
- Conditions
- Cesarean Section, Surgical Site Infection, Nosocomial Infection
- Trial name
- PRACTICAL (NCT03423147)
- Testing
- 2% chlorhexidine gluconate cloth, 4% Chlorhexidine gluconate vaginal scrub
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Angela Bianco
Contraception
Intrauterine Contraceptive Device (IUD) Placement at Time of C-Section
This is a pilot study of up to 10 women, which will test the hypothesis that the placement of copper IUDs through the uterine incision at the time of uncomplicated elective C-section is technically feasible and acceptable to…
- Trial name
- NCT00733278
- Testing
- Copper IUD ( ParaGard Intrauterine Contraceptive Device)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Pregnant Women
Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery
Hyperbaric bupivacaine 0.5% associated with opioids is the local anesthetic the most commonly used for spinal injection in cesarean section.
- Trial name
- NCT03036384
- Testing
- HB Prilocaine 2% (varying dose), HB Prilocaine 2%, Sufentanil
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Endometritis
The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery
PKAZ is a single institution study designed to evaluate the optimal dosing parameters for azithromycin for pre-surgical cesarean prophylaxis.
- Trial name
- PKAZ (NCT01464840)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Respiratory Depression
OSA Screen Negative With Spinal Duramorph
Non emergent scheduled cesarean sections will be consented to participate in this study of patients who have screened negative for obstructive sleep apnea and who are also BMI>/= 35 to have capnography monitoring postoperatively.
- Trial name
- NCT03151226
- Testing
- Capnography monitoring
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Analgesia, Obstetrical, Obstetric Surgical Procedures
Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery
Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing.
- Trial name
- NCT02789410
- Testing
- Morphine, Hydromorphone
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Spinal Anesthesia, Cesarean Section
Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?
The purpose of this study is to investigate whether the addition of a medication called epinephrine to spinal medications prolongs the duration of the anesthesia.
- Trial name
- NCT02369510
- Testing
- Low-dose epinephrine, High-dose epinephrine, No epinephrine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Hypertrophic Skin Condition of Anterior Abdomen
Negative Pressure Wound Therapy-PICO: Cosmesis in Repeat C-Sections
There are millions of births each year with 32% of women undergoing cesarean sections (C-sections), which results in skin scarring. Repeat C-sections increased by 178% from 1979-2010.
- Trial name
- NCT05266053
- Testing
- PICO 7 dressing, Standard wound dressing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Intrauterine Devices, Cesarean Section
Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
This is a randomized controlled trial among women who deliver by cesarean at UNC Women's Hospital and desire an Intrauterine Device (IUD) for contraception postpartum.
- Trial name
- IUD@CSD (NCT01539759)
- Testing
- Immediate Postplacental Placement of an IUD during cesarean delivery
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of North Carolina, Chapel Hill
Obstetric Anesthesia Problems, Bupivacaine Adverse Reaction
Thoraco Lumbar Vertebral Length and Bupivacaine Dosage in C-Section
Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the…
- Trial name
- bupivacaine (NCT06869434)
- Testing
- Group VBL (Thoracolumbal vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine, Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm, Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight.
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Physiological Effect of Drugs, Morphine
Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine
The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for…
- Conditions
- Physiological Effect of Drugs, Morphine, Analgesics, Analgesics, Opioid
- Trial name
- NCT04369950
- Testing
- 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hypotension
Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Previous research regarding the use of phenylephrine has excluded obese subjects (BMI >35). This subgroup of patients represents a large portion of the obstetric patient population locally and nationally.
- Trial name
- NCT01481740
- Testing
- Phenylephrine bolus, phenylephrine infusion
- Where
- 2 sites in United States, Canada
- Volunteers
- 178 people
- Sponsor
- IWK Health Centre
Pregnancy, Repeat Cesarean Section
Effect of a Patient-Centered Decision App on TOLAC
Cesarean delivery (CD) is the most common inpatient surgery in the US, accounting for nearly one third of births annually. In the last decade, the CD rate has increased by approximately 50%, with almost 1.3 million procedures…
- Conditions
- Pregnancy, Repeat Cesarean Section, Vaginal Births After Cesarean
- Trial name
- PROCEED (NCT02646423)
- Testing
- Prior CD Decision App
- Where
- 5 sites in United States
- Volunteers
- 1,485 people
- Sponsor
- University of California, San Francisco
Cesarean Section, Skin to Skin
Kangaroo Care in the Operating Room
The study was done to learn how kangaroo care in the operating room help mothers and infants.
- Conditions
- Cesarean Section, Skin to Skin, Kangaroo Care
- Trial name
- NCT07223775
- Testing
- Kangaroo Care
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cesarean Section, Pregnancy
INSORB Versus Subcuticular Sutures at Cesarean Section
The proposed study is a randomized controlled trial with two arms. All patients admitted to Labor and Delivery at Johns Hopkins Hospital for delivery will be approached and offered entry into our study.
- Trial name
- NCT01687972
- Testing
- Insorb absorbable staples, Absorbable sutures
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Johns Hopkins University
Cesarean Section Complications
Short Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure
Cesarean section (C/S) is an operation most commonly performed in Obstetrics and Gynecology Clinics. Complications related with incomplete healing of Kerr uterine incision after C/S (adhesions, separation (dehiscence)…
- Trial name
- NCT01287611
- Testing
- Purse string closure technique, Continuously locked closure technique
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?
Pain control after cesarean delivery is associated with improved breastfeeding and infant rooming-in times. In addition, inadequate analgesia leads to elevated plasma catecholamine concentrations, which negatively affect every…
- Conditions
- Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy, Complication of Labor and/or Delivery
- Trial name
- NCT00486902
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Northwestern University