Clinical trials: Cessation, Tobacco
Tobacco Dependence, Withdrawal Symptoms
Varenicline OTC Trial on Efficacy and Safety
The primary goal of the proposed research is to test whether varenicline (Chantix) is safe and effective as an over-the-counter (OTC) medication.
- Conditions
- Tobacco Dependence, Withdrawal Symptoms, Smoking Cessation
- Trial name
- VOTC (NCT03557294)
- Testing
- 1.0mg Varenicline b.i.d., 0.5mg Varenicline b.i.d.
- Where
- 2 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Tobacco Use Disorder, Opioid-use Disorder
A Trial of Directly Observed and Long-term Varenicline
This 2 x 2 factorial, randomized, double-blind, placebo-controlled trial will test two interventions: directly observed medication therapy, and long-term therapy with varenicline among smokers with opioid use disorder recruited…
- Trial name
- NCT03365362
- Testing
- Long-Term Varenicline, Short-Term Varenicline, Directly Observed Therapy
- Where
- United States
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Smoking Cessation
Tobacco-Related Disease Prevention Among Korean Americans
The study evaluates the effectiveness of an internet-based smoking cessation program for Korean Americans.
- Trial name
- CFCHKA (NCT02584127)
- Testing
- high reinforcement cessation program, low reinforcement cessation program
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Lung Cancer
Lung Cancer Screening Implementation Among Employees at Lyon Hospital
Several randomized studies have demonstrated the efficiency of lung cancer screening (LCS) on mortality rates. However, screening efficiency is related to the targeted population and the participation rate.
- Trial name
- ILYAD (NCT05452200)
- Testing
- Solicitation for lung cancer screening, added exams to the usual lung cancer screening
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Tobacco Use Disorder, Nicotine Dependence
Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement
This study involves the use of personalized nicotine patch dosing as a treatment strategy for smokers who cannot quit smoking after 2 weeks of using the standard nicotine patch dose.
- Trial name
- iT-NRT (NCT02439944)
- Testing
- Nicotine patch, Nicotine mouthspray
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Pancreatitis, Chronic, Pancreatitis, Acute
Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
The purpose of this research is to assess the effectiveness of two treatment strategies for smoking cessation in patients with acute recurrent pancreatitis or chronic pancreatitis who smoke cigarettes.
- Conditions
- Pancreatitis, Chronic, Pancreatitis, Acute, Recurrent Acute Pancreatitis, Smoking (Tobacco) Addiction
- Trial name
- NCT07171112
- Testing
- Standard Varenicline Dosing (1 mg BID), Bupropion 150 mg twice daily, Increased Varenicline Dosing (1mg TID)
- Where
- United States
- Sponsor
- Mayo Clinic
Tobacco Use Cessation, Addiction
An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention
The Healthy Futures: Alternative-to-Suspension Curriculum is a free, online curriculum developed to educate students and provide them with resources to quit tobacco/nicotine use.
- Trial name
- NCT06483412
- Testing
- Healthy Futures: Alternative-to-Suspension Curriculum
- Where
- United States
- Volunteers
- 2,540 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy, Nicotine Addiction
Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids
The goal of this clinical trial is to learn if low nicotine eliquids work to reduce exposure to nicotine, in addicted ecig users, without increasing consumption of other harmful constituents.
- Conditions
- Healthy, Nicotine Addiction, Electronic Cigarette Use
- Trial name
- NCT06602492
- Testing
- Lower nicotine e-liquid, Higher nicotine eliquid
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Rochester Institute of Technology
Tobacco Dependence
Single-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products. A Study in Healthy Smokers.
Single-dose nicotine pharmacokinetics with three oral nicotine replacement products.
- Trial name
- NCT01234792
- Testing
- 6 mg Experimental nicotine gum, 4 mg Nicotine Gum/, 2 mg Nicotine Gum
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- McNeil AB
Tobacco Use Disorder, Smoking Cessation
p16 Methylation for Smoking Cessation
Smoking cessation is often difficult for smokers to achieve for a variety of reasons including: difficulty with nicotine withdrawal, failure to perceive the benefits of smoking cessation, and failure to perceive the risks…
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Lung Cancer
- Trial name
- NCT01038492
- Testing
- p16 Methylation and Lung Cancer Education
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Tobacco Use Cessation
Feasibility, Adoption and Efficacy of A Virtual Reality Smoking Cessation Program for Patients Undergoing Lung Cancer Screening
Lung cancer is the second most common cancer and the leading cause of cancer related deaths in the United States (US . Tobacco use is the leading cause of lung cancer and tobacco control continues to be the primary method of lung…
- Trial name
- NCT06021652
- Testing
- MindCotine Virtual reality
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Nicotine Dependence, Schizophrenia
Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia
After successfully quitting smoking, smokers with schizophrenia are vulnerable to relapse shortly after discontinuation of treatment.
- Trial name
- NCT01576640
- Testing
- NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation
Tobacco Treatment in the Context of Lung Cancer Screening
The proposed study will test a medication plus text messaging intervention specifically designed for lung cancer screening patients.
- Trial name
- NCT03927989
- Testing
- Text messaging plus nicotine replacement therapy, Standard Care at Lung Cancer Screening
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Assessment of a Teachable Moment for Smoking Cessation
A teachable moment (TM) refers to life events or transitions, such as physician visits, early detection screening feedback, pregnancy, and hospitalization for, and diagnosis of, disease, that inspire health behavior change.
- Trial name
- TM (NCT00596440)
- Testing
- Transdermal nicotine patch
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Family Consultation for Health-Compromised Smokers
Although spousal support predicts the success of a smoker's cessation efforts, "social support" interventions based on teaching partners better support skills have had consistently disappointing results.
- Trial name
- NCT00400751
- Testing
- FAMCON (Family Consultation)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arizona
Nicotine Addiction, Smoking Cessation
e-Cigarettes Versus NRT Gum for Smoking Cessation
This is a randomized trial comparing electronic cigarettes (e-Cigarettes) to nicotine gum for smoking cessation. Participants will be randomly assigned to either e-cigarette use or nicotine gum use during a quit attempt.
- Trial name
- NCT01925781
- Testing
- Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Creighton University
Pregnancy
Tobacco Use in Pregnancy Intervention for Cessation
The proposed project will test the effectiveness of the novel delivery of an established tobacco cessation treatment among pregnant women in Kentucky.
- Trial name
- ToPIC (NCT03442530)
- Testing
- ToPIC, Tobacco Treatment As Usual (TTAU)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kristin Ashford
Cigarette Smoking
Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos
The parent project (1R21CA253600-01, R21 phase: 9/1/2020-8/31/2022, R33 phase: 9/1/2022-8/31/2025) aims to adapt and evaluate the efficacy of our theoretically and empirically based mobile health (mHealth) technology to help…
- Trial name
- SurvLaos (NCT05253573)
- Testing
- Nicotine patch, Self-help materials (to support smoking cessation), Smartphone-based automated treatment for smoking cessation
- Where
- 2 sites in Laos
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Smoking Cessation, Electronic Cigarette Use
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use.
- Conditions
- Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- CAN-DOSE (NCT06087328)
- Testing
- Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder
Tobacco Cessation in Postmenopausal Women (Part I) - 1
The purpose of this study is to evaluate the effects of ERT on appetitive behavior and withdrawal in short-term smoking cessation compared to smoking ad lib in postmenopausal female smokers.
- Trial name
- NCT00061061
- Testing
- Behavior Therapy
- Where
- United States
- Sponsor
- University of Minnesota
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