Clinical trials: Cessation, Tobacco
Smoking Cessation, Smoking, Cigarette
AXS-05 Phase II Trial on Smoking Behavior
This research study is designed with the purpose of evaluating a new drug, combination Dextromethorphan-Bupropion (AXS-05), for its effects on smoking behavior.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT03471767
- Testing
- AXS-05, Bupropion SR
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- James Davis
Nicotine Dependence
Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers.
- Trial name
- NCT01980550
- Testing
- sublingual nicotine
- Volunteers
- 250 people
- Sponsor
- National Institute on Drug Dependence, China
Tobacco Use Disorder, Head and Neck Neoplasms
A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers
Smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival and other outcomes, but many patients have difficulty quitting after their diagnosis.
- Conditions
- Tobacco Use Disorder, Head and Neck Neoplasms, Thoracic Neoplasms, Radiation
- Trial name
- NCT02188563
- Testing
- Comprehensive smoking cessation intervention, Enhanced usual care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Smoking Cessation
Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening
To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.
- Trial name
- NCT04798664
- Testing
- Removal of Financial Barriers, Financial Incentives, Mobile Health Application
- Where
- 5 sites in United States
- Volunteers
- 3,228 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Use Disorder, Nicotine Dependence
The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Clinically proven medications such as nicotine replacement therapy, bupropion and varenicline are available to help smokers quit but there are not widely used.
- Trial name
- MATCH (NCT02146911)
- Testing
- Bupropion, Varenicline, Weekly Motivational Emails
- Where
- Canada
- Volunteers
- 968 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily.
- Trial name
- NCT07425119
- Testing
- Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cigarette Smoking
Quit Smoking With Nicotine Patch and Exercise/Health Education (Females Only)
This research study is for FEMALE cigarette smokers who want to quit smoking. Participants will be provided with brief quit-smoking education at the beginning of the study and will receive the nicotine patch for 10 weeks, free of…
- Trial name
- QFH (NCT01522274)
- Testing
- Moderate intensity exercise, Health education
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Brown University
Physical Activity, Dietary Habits
Community and Clinician Partnership for Prevention
The purpose of this study is to evaluate the impact of strategies to develop and foster the relationship between primary care practices and community resources to address specific unhealthy behaviors (tobacco use, poor nutrition…
- Conditions
- Physical Activity, Dietary Habits, Tobacco Use Cessation
- Trial name
- C2P2 (NCT00577759)
- Testing
- Active Intervention, Passive Intervention, No intervention
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Tobacco Smoking
Promoting Evidenced-Based Tobacco Smoking Cessation Treatment in Community Mental Health Clinics
This pilot study will examine whether an implementation intervention will improve delivery of evidence-based treatment for tobacco smoking cessation for patients in community mental health clinics.
- Trial name
- IMPACT (NCT04796961)
- Testing
- Implementation Intervention
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder
Effect of Galantamine on Short-term Abstinence
This is a randomized, double-blind, placebo-controlled study to test whether a medication called galantamine (Brand Name: Razadyne) will help smokers quit and whether it reduces cognitive problems that smokers experience during a…
- Trial name
- GAL-K (NCT01669538)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Behavioral Smoking Cessation Treatment - 1
Our primary goal is to examine the effectiveness of a multi-factor maintenance treatment strategy in promoting longer-term smoking abstinence.
- Trial name
- NCT00110825
- Testing
- Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Cessation
A Multi-Media Approach to Partner Support in Smokeless Tobacco Cessation (UCare-ChewFree)
In an earlier study, the investigators developed a guidebook that taught women supportive behaviors to help their husbands/partners quit smokeless tobacco.
- Trial name
- NCT01885221
- Testing
- Multimedia Support Intervention
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Tobacco Use Cessation, Tobacco Use
Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya
People living with HIV (PLHIV) have higher rates of tobacco use than the general population and higher rates of disease and death compared with PLHIV who do not use tobacco.
- Trial name
- NCT05351606
- Testing
- Tobacco Use Cessation Counselling Sessions, Bupropion, Nicotine patch
- Where
- Kenya
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cigarette Smoking
Contingency Management for Smoking in Substance Abusers
Patients (N=102) who meet diagnostic criteria for alcohol, cocaine, marijuana, or opiate abuse or dependence will meet with research staff on two days for quit preparation sessions (2 per day).
- Trial name
- R21 (NCT00683033)
- Testing
- Contingency Management, Brief smoking cessation counseling
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- UConn Health
Cigarette Smoking, Smoking Cessation
Benefits of Tobacco Free Cigarette
Background. Smoking is considered a global public health problem. For this reason, the smoking dependence was called by experts as a global epidemic.
- Trial name
- BETOFREE (NCT02422914)
- Testing
- Smoking cessation program TFC and activity tracker, Smoking cessation program TFC-free and activity tracker, Smoking cessation program and activity tracker
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Milan
Smoking Cessation, Tobacco Cessation
Effectiveness of the Swedish National Tobacco Quitline
The purpose of this study was to compare the effectiveness of the high-intensity proactive service with the low-intensity reactive service at the Swedish National Tobacco Quitline (SNTQ).
- Trial name
- SNTQ (NCT02085616)
- Testing
- Proactive service, Reactive service
- Where
- 3 sites in Sweden
- Volunteers
- 586 people
- Sponsor
- Uppsala University
Smoking Cessation
A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation
The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.
- Trial name
- NCT01102114
- Testing
- NicVAX Vaccine
- Where
- 25 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nabi Biopharmaceuticals
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smokeless Tobacco, Tobacco Use Cessation
Telephone Counseling for Snuff Users
The primary objective is to evaluate the effectiveness of telephone-based counseling in promoting smokeless tobacco cessation among residents of Minnesota.
- Trial name
- NCT00265681
- Testing
- Phone counseling and written materials
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- HealthPartners Institute
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