Clinical trials: Chagas Disease
Chagas Disease
Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease
o study population pharmacokinetics in Benznidazole-treated adult patients with Chronic Chagas Disease to get information to optimize drug doses.
- Trial name
- CINEBENZ (NCT01755403)
- Testing
- Benznidazole
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Barcelona Centre for International Health Research
Chagas Cardiomyopathy, Speckle Tracking Echocardiography
Cardiac Mechanics by Speckle Tracking as a Prognostic Predictor in Patients With Chagas Cardiomyopathy
This study aims to evaluate the prognostic value of myocardial mechanics parameters, including global longitudinal strain (GLS) and mechanical dispersion (MD), assessed through speckle tracking echocardiography, in patients with…
- Conditions
- Chagas Cardiomyopathy, Speckle Tracking Echocardiography, Arrythmias, Sudden Death
- Trial name
- ST-Chagas (NCT06806722)
- Where
- Brazil
- Volunteers
- 153 people
- Sponsor
- University of Sao Paulo
Chagas Heart Disease
Impact of the Pharmaceutical Care on the Quality of Life in Patients With Chagas Heart Disease
The investigators hypothesize that pharmaceutical care may constitute an important tool for the clinical management of these patients by improving their compliance to their treatment with consequent improvement in their quality…
- Trial name
- ChagasCare (NCT01566617)
- Testing
- Standard care and Pharmaceutical care, Standard care
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Evandro Chagas Institute of Clinical Research
Healthy Volunteers
First-in-Human Trial of Oral AN2-502998
First-in-Human Phase 1, Single-Center, Randomized, Blinded, Placebo-Controlled Trial in Healthy Adults to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Oral AN2-502998
- Trial name
- NCT07024589
- Testing
- AN2-502998
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AN2 Therapeutics, Inc
Chagas Disease, Heart Diseases
Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
The study "Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients with Chagas Disease" is a prospective, multicenter, randomized study that is being conducted at several centers in Latin America with…
- Trial name
- NCT01539161
- Testing
- Implantable Cardiac Monitor, Standard of Care
- Where
- 4 sites in Argentina, Colombia
- Volunteers
- 12 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Chronic Chagas Disease, Indeterminate
Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease
This study will assess the safety and efficacy of E1224, a pro-drug of ravuconazole, in individuals with chronic indeterminate Chagas disease recruited in research centres in Tarija and Cochabamba, Bolivia.
- Trial name
- NCT01489228
- Testing
- E1224, Benznidazole
- Where
- 2 sites in Bolivia
- Volunteers
- 230 people
- Sponsor
- Drugs for Neglected Diseases
Chagas Disease
An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health
This is an observational study in which data from women with Chagas disease who will take or have already taken nifurtimox during pregnancy and the impact on their babies are studied.
- Trial name
- NCT05477953
- Testing
- Nifurtimox (BAYA2502)
- Where
- 12 sites in United States, Argentina and 10 more
- Volunteers
- 50 people
- Sponsor
- Bayer
Chagas Disease
Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction
The prevalence of Chagas' disease continues high even in the developed countries. Chagasic Cardiomyopathy with preserved ventricular function is an understudied form of Chagas disease.
- Trial name
- CH0660/10 (NCT02295215)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Bioequivalence
Study to Assess Bioequivalence of a New Nifurtimox Oral Tablet Formulation
The primary objective of the current study is to investigate the bioequivalence of a newly developed 120 mg nifurtimox tablet formulation (Test treatment) compared with the 120 mg nifurtimox tablet currently used in the Bayer…
- Trial name
- NCT03708133
- Testing
- Nifurtimox (Lampit, BAYA2502)_Test, Nifurtimox (Lampit, BAYA2502)_Reference
- Where
- Argentina
- Volunteers
- 24 people
- Sponsor
- Bayer
Chagas Disease
Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease
The purpose of this study is to estimate the gain in sensitivity of several multiple-sample strategies of PCR samples with respect to the current standard (single sample of 10 ml) to detect Chagas chronic stage at baseline and to…
- Trial name
- PCR (NCT01678599)
- Testing
- Benznidazole
- Where
- Bolivia
- Volunteers
- 220 people
- Sponsor
- Drugs for Neglected Diseases
Chagas Disease, Lactation
Study of Benznidazole Transfer Into Breastmilk in Lactating Women With Chagas Disease
The investigators propose to study the transfer of benznidazole into breastmilk from the blood of lactating women who receive the drug for the treatment of Chagas disease.
- Trial name
- LACTBENZ (NCT01547533)
- Where
- Argentina
- Volunteers
- 10 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Chagas Disease
Population Pharmacokinetics of Benznidazole in Children With Chagas Disease
Background: Chagas disease is a parasitic infection caused by the Trypanosome cruzi. The initial phase of the infection happens mainly in children. Up to 10% of infected children die.
- Trial name
- NCT00699387
- Testing
- Benznidazole
- Where
- Argentina
- Volunteers
- 37 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Chagas Disease
Abbott ESA Chagas Assay Post-Market Study
The study is conducted to meet an FDA post market commitment to collect and report data on the performance of the ESA Chagas assay.
- Trial name
- ESA (NCT01662362)
- Testing
- Testing Donor Specimens with ESA Chagas
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Abbott Diagnostics Division
Chagas' Disease (Chronic) Nos
Oral Fexinidazole Dosing Regimens for the Treatment of Adults With Chronic Indeterminate Chagas Disease
This study focuses on the evaluation of low doses (600 and 1200 mg) and short treatment duration (at 3, 7 and 10 days) of fexinidazole (Fexi) to determine the minimal efficacious and safe dose for the treatment of adult patients…
- Trial name
- FEXI12 (NCT03587766)
- Testing
- Fexinidazole
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Drugs for Neglected Diseases
Chronic Chagas
Prospective Evaluation of Rapid Diagnostic Tests for Trypanosoma Cruzi Infection
Chagas disease (CD) is the most significant endemic zoonosis in Argentina. Two-thirds of affected individuals live in urban areas but only 10% globally are aware of their infection.
- Trial name
- NCT07304349
- Where
- 4 sites in Argentina
- Volunteers
- 3,234 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Parasitologia Dr. Mario Fatala Chaben
Chagas' Disease
Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study
This study evaluated the effect of food on the absorption of the drug as well as safety and tolerability in adults suffering from chronic Chagas' disease In addition pharmacokinetics of the drug following 120 and 240 mg single…
- Trial name
- NCT03334838
- Testing
- Nifurtimox (Lampit, BAYA2502)
- Where
- Argentina
- Volunteers
- 36 people
- Sponsor
- Bayer
Chagas Disease
Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease
One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imaging modality with useful applications in…
- Trial name
- NCT02327052
- Testing
- No intervention was performed.
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Sao Rafael
Chagas Disease, Chagas Cardiomyopathy
Physical Exercise Program in Chronic Chagas Heart Disease
The aim of this investigation is to evaluate the impact of exercise in a cardiac rehabilitation program on functional capacity, clinical markers, quality of life and biomarkers in patients with chronic chagasic cardiomyopathy.
- Trial name
- PEACH (NCT02517632)
- Testing
- Exercise, nutritional and pharmaceutical counceling, Nutritional and pharmaceutical counceling
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Chagas' Disease
Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease
The purpose of this study is to describe the population pharmacokinetics parameters of benznidazole in children with acute or early chronic indeterminate form of Chagas Disease.
- Trial name
- Pop PK Chagas (NCT01549236)
- Testing
- Benznidazole 12,5mg or 100mg
- Where
- 3 sites in Argentina
- Volunteers
- 80 people
- Sponsor
- Drugs for Neglected Diseases
Chagas Disease
Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)
BACKGROUND: Chagas Disease (ChD) remains as one of the most neglected diseases in the world, with 8-10 million infected people and only one marginally effective therapeutic.
- Trial name
- SaMi-Trop (NCT02646943)
- Volunteers
- 1,959 people
- Sponsor
- University of Sao Paulo