Clinical trials: Challenge Test
Cardiovascular Diseases, Hyperlipidemias
The Mixed Meal Challenge Study
The purpose of this study is to assess sample collection conditions for various dietary challenges (fat, sugar, and mixed) and determine the optimal fasting and post-meal sample collection time points for future studies on a…
- Trial name
- NCT05087823
- Testing
- Lipid Challenge, Glucose Challenge, Mixed Meal Challenge
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Emory University
Asthma
A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With Asthma
The main objective of this study is to evaluate the safety and tolerability of multiple fixed doses of MEDI-528 in adult patients with stable asthma and exercise-induced bronchoconstriction (EIB).
- Trial name
- NCT00590720
- Testing
- MEDI528 50 mg
- Where
- 12 sites in United States, Canada
- Volunteers
- 11 people
- Sponsor
- MedImmune LLC
Asthma
A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing
The study will assess three different nebulizers for use in methacholine challenge testing in order to determine if the Aeroneb Solo would make a suitable replacement for the long-used and now obsolete Wright and Bennett-Twin…
- Trial name
- NCT02822859
- Testing
- Wright nebulizer, Bennett-Twin nebulizer, Aeroneb Solo
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Hyperreactive Airway Disease
Methacholine Challenge Test (MCT) in Healthy Adults
Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls.
- Trial name
- NCT06509659
- Testing
- Methacholine Challenge Test
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Allergi- og Lungeklinikken, Elsinore
Dietary Modification, Cardiovascular Diseases
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota.
- Trial name
- NCT03781011
- Testing
- Vegetarian diet intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Healthy, Metabolism
Improving Resilience With Whole Grain Wheat
This study investigates the health benefits of whole grain wheat on cardiovascular/ cardio-metabolic health, including glucose metabolism, by means of applying a mixed meal challenge.
- Trial name
- Graandioos (NCT02385149)
- Testing
- whole grain wheat, refined wheat
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Nut Allergy in Children
Tree Nuts Allergies: Does a Single Nut Allergy Necessitate the Dietary Eviction of Other Tree Nuts?
The aim of this study is to identify, based on standardized food provocation tests, which nuts allergic patients need a selective, or a complete dietary eviction of all kind of nuts (nuts being defined as peanut, all tree nuts…
- Trial name
- ProNut (NCT01744990)
- Testing
- Oral food challenges to multiple nuts
- Where
- 4 sites in Spain, Switzerland and 1 more
- Volunteers
- 130 people
- Sponsor
- University Hospital, Geneva
Orthostatic Hypotension
Impedance Threshold Device Tilt Study
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
- Trial name
- NCT00137319
- Testing
- Impedance threshold device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- United States Army Institute of Surgical Research
Cardiac Surgery
End-expiratory and End-inspiratory Occlusion Tests to Predict Fluid Responsiveness
The purpose of the study is to verify the efficacy of using end-expiratory and end-inspiratory occlusion tests as an index of fluid responsiveness in mechanically ventilated patients with cardiac surgery.
- Trial name
- EEOFR (NCT03485833)
- Testing
- EEO and EIO test
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Allergic Rhinitis
A Study to Test a New Decongestant in Patients With Allergic Rhinitis Following a Nasal Allergen Challenge
An H3 receptor antagonist should reduce the congestion associated with allergic rhinitis. A nasal allergen challenge will be given to patients to induce rhinitis symptoms and acoustic rhinometry will be used to measure the…
- Trial name
- NCT00562120
- Testing
- Allegra, Allegra-D, PF-03654746
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Pfizer
HIV Infections, Mental Health
Testing the WeCare Intervention to Address Mental Health and Medication Adherence Challenges Among MSM in South Africa
The goal of this clinical trial is to learn if the WeCare intervention-an adapted Friendship Bench program that integrates problem-solving therapy, minority-stress-informed content, and explicit PrEP/ART adherence skills-improves…
- Trial name
- NCT07226323
- Testing
- WeCare, Standard of Care
- Where
- South Africa
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Penicillin Allergy
The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin
The incidence of reactions during penicillin challenge tests among children with suspected penicillin allergy
- Trial name
- NCT02702349
- Testing
- penicillin test
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Dietary Exposure
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity
In this project, the investigators aim to explore the impact of dietary L-carnitine supplementation on the TMAO production capacity of gut microbiota.
- Trial name
- NCT02838732
- Testing
- L-carnitine supplementation (500 mg per tablet per day, purchased from GNC company)
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
NAFLD, Type 2 Diabetes
Postprandial VLDL-triglyceride Metabolism in Type 2 Diabetes Patients With and Without NAFLD
Non-alcoholic fatty liver disease (NAFLD) covers a spectrum from simple reversible hepatic steatosis to inflammation and fibrosis termed steatohepatitis (NASH).
- Trial name
- NCT05044130
- Testing
- High-fat mixed-meal tolerance test (HF-MMTT)
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- University of Aarhus
Healthy, Chronic Kidney Diseases
Exploring the Mechanisms of Indoxyl Sulfate Production by Oral Tryptophan Challenge Test
Cardiovascular disease (CVD) is prevalent in patients with chronic kidney disease (CKD) and is associated with extremely poor prognosis.
- Trial name
- NCT04117191
- Testing
- Doctor's Best L-Tryptophan
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Allergic Reaction
Interest of Challenge Tests for Diagnosis of Immediate Hypersensitivity Against Iodinated Contrast Agents
Iodinated contrast agents (ICA) are widely used in medical imaging. They provide however a risk of immediate hypersensitivity reactions (IHS). The risk of anaphylactic shock is estimated at 1/100 000 injections.
- Trial name
- DHIODE (NCT03525496)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Cardiometabolic Risk, Abdominal Obesity
Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention
The aim of the study is to evaluate the synergistic effects of daily consumption of food products fortified with bioactive components (fibres, polyphenols, omega-3, Slow Digestible Starch) for 9 weeks, compared to the daily…
- Trial name
- SINFONI (NCT04190706)
- Testing
- bioactive components fortified food products intake (biscuits and cookies), control food products intake (biscuits and cookies)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Type2 Diabetes, Postprandial Hyperglycemia
Postprandial Metabolites of Meal Challenge Test in Diabetes State
Postprandial hyperglycemia is a hallmark feature of Type 2 Diabetes Mellitus (T2D), and persistent elevated glycemic level has shown to be strongly associated with oxidative stress, and a risk factor for cardiovascular disease…
- Trial name
- NCT04234763
- Testing
- Strategies to lower postprandial hyperglycemia in T2D patients, Control group
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- Universiti Putra Malaysia
Asthma
Anti-histamines and Methacholine Challenges.
The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction.
- Trial name
- NCT01985789
- Testing
- Diphenhydramine, cetirizine, desloratadine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Don Cockcroft
Allergy
New Validated Recipes for Double-blind Placebo-controlled Low Dose Food Challenges
This study aimed to validate new recipes for cow's milk, hen's egg, soy, cod and wheat, to be used in blinded low-dose food challenges.
- Trial name
- NCT01633840
- Testing
- Elemental E028 with added food allergens, Elemental E028
- Where
- Sweden
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Christina West