Clinical trials: Change; Mental
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Dementia, Parkinson
Autologous Stem/Stromal Cells in Neurological Disorders and Disease
The study deals with evaluation of safety and efficacy of use of stem/stromal cell isolates from autologous microvasculature in neurological, non-neoplastic disease.
- Conditions
- Dementia, Parkinson, Altered Behavior in Alzheimer Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NDD (NCT03297177)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline Infusion
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Regeneris Medical
Binge-Eating Disorder, Obesity
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders
This study will test the relative efficacy and effectiveness of the combination of naltrexone and bupropion (NB) medication as a treatment for binge-eating disorder (BED) in patients with obesity.
- Trial name
- NCT03946111
- Testing
- Naltrexone and Bupropion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Yale University
PTSD
Pilot-Study DCPT for PTSD in Adolescents and Young Adults
The aim of this pilot study is to evaluate the developmentally adapted cognitive processing therapy (D-CPT)in adolescents suffering from childhood abuse(CA)or physical abuse (PA) related PTSD.
- Trial name
- Pilot-DCPT (NCT01870271)
- Testing
- Developmentally adapted cognitive processing therapy
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Goethe University
Dementia, Mild, Depression
Decision Making Tool for Firearm Storage
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
- Trial name
- NCT06382194
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Primary Insomnia
Different Acupoints Compatibility Difference of the Effect of Treatment of the Primary Insomnia
With primary insomnia as the research object, by the method of multi-center RCT and needle single cavity and different acupoints compatibility treatment for primary insomnia, to Pittsburgh sleep quality index(PSQI) and…
- Trial name
- NCT02448602
- Testing
- acupuncture
- Where
- China
- Volunteers
- 333 people
- Sponsor
- Changchun University of Chinese Medicine
Childhood Trauma, Major Depressive Disorder
HPA Axis Activity Due To Early Traumatic Stress and Metabolic Symptoms
This study evaluates the association between early trauma, depression and metabolic symptoms.
- Trial name
- Cort-Metab (NCT02398877)
- Testing
- stress
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Anxiety
Attention Bias Modification for Anxiety: A Randomized Control Trial With Biomarkers
Computer-based attention bias modification treatment (ABMT), which is brief, cost-effective, and easy to administer, targets a key mechanism in pathological anxiety - the threat bias, or exaggerated attention feared or…
- Trial name
- ABMT (NCT02200003)
- Testing
- attention bias modification for anxiety
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hunter College of City University of New York
Major Depressive Disorder
Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis
Despite significant advances in pharmacological treatment, the global burden of depression is increasing worldwide. The major challenge in antidepressant treatment is the clinicians' inability to predict the variability in…
- Trial name
- NCT02330679
- Testing
- Desvenlafaxine
- Where
- 2 sites in Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Postnatal Depression
LTP+CaCBT for Treating Postnatal Depression and Improving Child Wellbeing in Jos Nigeria
The project aims to test the feasibility, acceptability, cultural appropriateness and effectiveness of LTP+CaCBT for treating postnatal depression and to enhance the mental health and wellbeing of mothers and their children in…
- Trial name
- LTP+CaCBT (NCT04644081)
- Testing
- LTP, CaCBT, TAU
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Mild Cognitive Impairment
Functional MRI Changes Resulting From the Feuerstein Program in Older People With Mild Cognitive Impairment (MCI)
Background: The Feuerstein Instrumental Enrichment Program was designed to prevent mental deterioration and preserve cognitive abilities among people aged 60 and above.
- Trial name
- NCT03447236
- Testing
- Feuerstein Program
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Rambam Health Care Campus
Postoperative Delirium, Postoperative Cognitive Dysfunction
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
- Trial name
- NCT05574400
- Testing
- Dextrose Water, Caffeine citrate
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Multiple Sclerosis, Cognitive Dysfunction
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS)
The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Cognitive Dysfunction, Memory Disorders
- Trial name
- HOBSCOTCH-MS (NCT06145737)
- Testing
- HOme-Based Self-management and COgnitive Training CHanges lives (HOBSCOTCH)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Emergence Agitation, Emergence Delirium, Anesthesia
Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.
This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general…
- Conditions
- Emergence Agitation, Emergence Delirium, Anesthesia, Emergence From Anesthesia, Emergence Delirium
- Trial name
- NCT07435675
- Testing
- ultrasound-guided greater auricular nerve block (GANB)
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Healthy, Mood Disorder
Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal Subjects
St. John's Wort is a popular dietary supplement that many people take to elevate mood or relieve stress. This study will test in normal volunteers whether this preparation may alter mood and if so, by what means.
- Trial name
- NCT00001919
- Testing
- Hypericum (LI-160)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Occupational Health, Sleep
Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue
The U.S. registered nurse (RN) workforce is the largest in the Healthcare and Social Assistance Sector and is at high risk for injuries and errors due to poor sleep and fatigue.
- Conditions
- Occupational Health, Sleep, Fatigue, Nurse
- Trial name
- RN-SLEEP (NCT06105307)
- Testing
- RN-SLEEP, Healthy Habit - Educational Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Neck Pain, Kinesiophobia
Minimal Clinical Important Change of the Turkish Versions of the FABQ TKS, and PCS in Patients With Chronic Neck Pain
To investigate the reliability and sensitivity of the Fear-Avoidance Beliefs Questionnaire, Tampa Kinesiophobia Scale, and Pain Catastrophizing Scale in patients with chronic nonspecific neck pain undergoing multidisciplinary…
- Conditions
- Neck Pain, Kinesiophobia, Fear of Movement
- Trial name
- NCT06194812
- Testing
- Pain Catastrophizing scale
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Schizophrenia
Pharmacokinetic Study of MIN-101 in Healthy Subjects
The aim of the study is to assess how MIN-101 is taken up by the body when given in different amounts and in different formulations.
- Trial name
- NCT02232529
- Testing
- MIN-101
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Minerva Neurosciences
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