Clinical trials: Change; Mental
Depression and Suicide Ideation, Anxiety
Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence
This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high…
- Conditions
- Depression and Suicide Ideation, Anxiety, PTSD
- Trial name
- NCT06980441
- Testing
- Problem Management Plus with Emotional Processing module
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Peace of Mind Association (PoMA)
Tourette Syndrome
Pilot Study of the Modified Atkins Diet for Tourette Syndrome
Pharmacotherapy has long been considered the primary approach for tic suppression in Tourette syndrome (TS). Unfortunately, medications are often ineffective and frequently have significant side-effects.
- Trial name
- NCT00952601
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Gastric Retention
Study to Evaluate Safety/Duration in Stomach of Extended Release Capsules Containing Memantine Hydrochloride in Healthy Adults
To assess how long memantine hydrochloride (HCl) (50 mg) extended release capsules stay in the stomach as determined by imaging assessment (MRI or abdominal ultrasound).
- Conditions
- Alzheimer Disease, Gastric Retention, Healthy
- Trial name
- NCT03711825
- Testing
- LYN-057, Imaging Assessment (MRI), Imaging Assessment (U/S)
- Where
- Australia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lyndra Inc.
Cognitive Change, Sleep Deprivation
Sleep Deprivation Study
The purpose of this study is to evaluate the measures of brain function, both neurophysiological (event-related potentials (ERPs) and functional (cognitive assessments), in response to sleep deprivation.
- Conditions
- Cognitive Change, Sleep Deprivation, Caffeine
- Trial name
- NCT05560620
- Testing
- Sleep Deprivation, Caffeine, No Caffeine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NeuroCatch Inc.
Anxiety Disorders
Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth Who do Not Respond to CBT
First-line psychosocial treatments for anxiety disorders in children are largely exposure-based cognitive behavioral therapies (CBTs).
- Trial name
- NCT02272959
- Testing
- Attention bias modification treatment (ABMT), Attention Control Condition
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Yair Bar-Haim
Healthy
A Study to Assess the Safety, Tolerability and Pharmacokinetics of Modified-Release Formulations of AZD1446 After Oral Single and Repeated Doses
The purpose of this study is to assess safety, tolerability and pharmacokinetics of AZD1446 in young and elderly healthy Japanese volunteers.
- Trial name
- NCT01199315
- Testing
- AZD1446
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
PTSD
Evaluation of a Novel Behavior Change Intervention for Posttraumatic Stress
Evaluation of a Novel Behavior Change Intervention for Posttraumatic Stress
- Trial name
- NCT05700578
- Testing
- Safety Behavior Elimination for Traumatic Stress (SBETS), Modifiable Behavior Intervention (MoBI)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Florida State University
Support Persons, Family Members
Recovery Inspired Support Engagement (RISE) Pilot
The goal of this clinical trial is to learn if a 1-on-1 support program is easy to complete and acceptable for people supporting loved ones who have recently received treatment for substance use.
- Conditions
- Support Persons, Family Members, Chosen Family, Romantic Partners
- Trial name
- (RISE) (NCT07519759)
- Testing
- ITC
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Quality of Life, Life Change Events
A Pilot Study To Assess Guidance in and Subsequent Use of Mind-Body Techniques on the Quality of Life of Cancer Patients
Aim: To answer the questions of whether a Mind-Body Medicine (MBM) skills group facilitated face-to-face and online can improve measures of Quality of Life (QOL) in a population of cancer patients.
- Conditions
- Quality of Life, Life Change Events, Neoplasms
- Trial name
- NCT01586546
- Testing
- Face-to-Face MBM Skills Group, Waitlist Control I, Waitlist Control II
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Absenger Cancer Education Foundation
Schizophrenia, Bipolar Disorder
Health Promotion and Fitness for Younger and Older Adults With SMI
The goal of this project, which has not changed, is to improve the health and fitness of persons with serious mental illness (SMI) using an innovative model: In SHAPE Lifestyles.
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- InSHAPE (NCT02090335)
- Testing
- In SHAPE, Fitness Club Membership
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Altered Mental Status
Intranasal Dexmedetomidine vs. Standard of Care for Emergency Department (ED) Procedural Sedation in the Older Adult
The purpose of the study is to determine if intranasal dexmedetomidine could be an alternative to the current standard of care (injectable benzodiazepines or antipsychotics) for sedation prior to computerized tomography (CT) or…
- Trial name
- NCT06370442
- Testing
- Dexmedetomidine, Lorazepam, Haloperidol
- Volunteers
- 60 people
- Sponsor
- State University of New York - Upstate Medical University
Sleep Deprivation, Burnout, Professional
Cognitive Performance After a Night Shift in Internal Medicine Residents
A quasi-experimental design where internal medicine residents in a high complexity hospital were assessed after a 24-hour shift for cognitive impairment by a trained neurologist.
- Conditions
- Sleep Deprivation, Burnout, Professional, Cognition Disorders
- Trial name
- NCT04053556
- Where
- Argentina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Posttraumatic Stress Disorder, PTSD
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly…
- Trial name
- ADAPT-PTSD (NCT07176273)
- Testing
- Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment
- Where
- 4 sites in United States
- Volunteers
- 302 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Ketogenic Dieting
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
To initiate a low-carbohydrate, high-fat (LCHF) or ketogenic dietary (KD) intervention among a cohort of outpatients with either schizophrenia or bipolar illness who also have metabolic abnormalities, overweight/obesity, and/or…
- Conditions
- Obesity, Ketogenic Dieting, Metabolic Syndrome, Bipolar Disorder
- Trial name
- NCT03935854
- Testing
- LCHF, Ketogenic Diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Mild Cognitive Impairment, Alzheimer Disease
Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure
The proposed project will assess long-term changes to health/lifestyle, advanced planning, and research engagement that Black and White patients with Amnestic Mild Cognitive Impairment (aMCI) make following disclosure of positron…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Amnestic Mild Cognitive Disorder
- Trial name
- SHARED III (NCT05584241)
- Testing
- Diagnostic Disclosure Protocol, Biomarker Disclosure Protocol
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Michigan
Preoperative Care, Anxiety
Use of Maltodextrins in the ERAS Preoperative Fasting Protocol in Pediatric Surgery
This monocentric prospective randomized controlled pilot study aims to evaluate the effectiveness of preoperative maltodextrin administration within an Enhanced Recovery After Surgery (ERAS) protocol in pediatric surgical…
- Conditions
- Preoperative Care, Anxiety, Pediatric Surgery
- Trial name
- ERAS-MALTO (NCT07686029)
- Testing
- Maltodextrin Clear Liquid, Non-Sugared Clear Liquid
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Substance Use Disorders
ZOlpidem and the stRengthening of pRescription regulatiOn
For several years, the French Addictovigilance Network (FAN) highlights potential problematic consumptions with zolpidem. To prevent abuse and misuse of zolpidem, the French Health Products Agency has changed the regulatory…
- Trial name
- ZORRO (NCT03584542)
- Testing
- No interventional study
- Where
- France
- Volunteers
- 449 people
- Sponsor
- Nantes University Hospital
Sleep Quality, Compliance
Changes in 24-hour Activity Cycle Behaviors During a Time-Restricted Eating Intervention in College-Aged Women
Time-restricted Eating (TRE) is a dietary approach that limits food intake to 4 - 12-hour windows without intentionally altering diet quality.
- Conditions
- Sleep Quality, Compliance, Physical Activity, Sedentary Behaviors
- Trial name
- DAWG-TREAT (NCT07520786)
- Testing
- Time Restricted Eating, Control
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Pain, Anxiety
Natural Sound Therapy on Procedural Pain and Anxiety During Negative Pressure Wound Therapy Dressing Changes
The goal of this clinical trial is to learn if personalized natural sound therapy works better than standardized natural sound therapy for reducing procedural pain during negative pressure wound therapy dressing changes.
- Trial name
- NPAWTDC (NCT07854717)
- Testing
- Personalized Natural Sound Therapy, Standardized Natural Sound Therapy
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Basrah
Health Promotion, Obesity
Study of a Learning Collaborative to Implement Health Promotion in Mental Health
Healthcare organizations have increasingly formed quality-improvement Learning Collaboratives to improve care for specific populations; however, there are few data on the effectiveness of this strategy compared to conventional…
- Conditions
- Health Promotion, Obesity, Organizational Innovation, Mental Health Services
- Trial name
- NCT03891368
- Testing
- Virtual Learning Collaborative, Technical Assistance
- Volunteers
- 55 people
- Sponsor
- Massachusetts General Hospital
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