Clinical trials: Change; Mental
Obesity & Overweight, Obesity & Overweight Sleep
Sleep Evaluation Before and After Metabolic Surgery
Obesity is frequently associated with sleep disturbances, including poor sleep quality, insomnia symptoms, daytime sleepiness, and obstructive sleep apnea.
- Conditions
- Obesity & Overweight, Obesity & Overweight Sleep, Sleep, Metabolic Surgery
- Trial name
- SLEEP-BAM (NCT07693491)
- Testing
- Primary Metabolic Surgery
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Eating Disorder, Anorexia
Adaptive Treatment for Adolescent Anorexia Nervosa
The investigators are conducting a randomized controlled trial using an adaptive design for adolescents (ages 12-18) with anorexia nervosa to compare standard Family Based Treatment (FBT) to adaptive FBT with an Intensive…
- Conditions
- Eating Disorder, Anorexia, Anorexia Nervosa, Anorexia in Adolescence
- Trial name
- NCT03097874
- Testing
- Family Based Treatment, Family Based Treatment + Intensive Parental Coaching
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Stanford University
Gender Dysphoria
Transition in Transgender
The aim of this longitudinal, observational study is to investigate the effects of gender-affirming hormone treatment in FTM (female to male) and MTF (male to female) transgender (TG) people with regard to changes in brain…
- Trial name
- NCT04736797
- Where
- 2 sites in Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Violence, Substance Use
Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violence Involvement
This study will use a randomized control trial (RCT) design to administer two versions of a multisession remote behavioral intervention for youth seeking Emergency Department care for a violent injury with the goal to reduce…
- Conditions
- Violence, Substance Use, Criminal Behavior, Violence in Adolescence
- Trial name
- NCT04850274
- Testing
- Remote Therapy Intervention (RTI), Artificial Intelligence Remote Therapy Intervention
- Where
- 4 sites in United States
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depressive Disorder
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder
Overall, the objective of this pilot study is to utilize the IL-6 receptor antagonist tocilizumab to prospectively evaluate the role of IL-6 in the antidepressant and immunological effects of whole body hyperthermia (WBH).
- Trial name
- NCT03787290
- Testing
- Tocilizumab, Whole-Body Hyperthermia
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Depression Symptoms, Anxiety Symptoms
Developing a Booster Session for Problem Management Plus in the Bahamas: A Pilot Randomized Controlled Trial
Therapists at the Grand Bahama Resilience Center (GBRC) will be trained to deliver Problem Management Plus (PM+), a WHO intervention.
- Trial name
- NCT07208851
- Testing
- Problem Management Plus booster session
- Where
- The Bahamas
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The New School
Psychological Stress, Anxiety
Mindfulness Training in U.S. Army Cohorts
This project aims to contextualize delivery of mindfulness training to U.S. Army personnel, evaluate its effectiveness on measures of executive functions and psychological well-being, and determine best practices for its delivery.
- Conditions
- Psychological Stress, Anxiety, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT03310112
- Testing
- 4-week MBAT, 2-week MBAT
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tourette Syndrome, Apathy
Apathy in Tourette Syndrome and Changes in Quality of Life
Tourette syndrome is a complex neuropsychological disorder with both motor and vocal tics associated with multiple psychological co-morbidities. Apathy has not been widely studied in patients with Tourette syndrome.
- Trial name
- NCT02765178
- Testing
- Children's Motivation Scale, Yale Global Tic Severity Scale (YGTSS), Studies Depression Scale for Children (CES-DC)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Florida
Autism, Autism Disorders and Maternal Stress
Adapting the Sensory Environment to Reduce Stress in Children With Autism During Dental Visits
This study aims to evaluate the impact of a sensory-adapted dental environment (SADE) on the stress levels and behavioral responses of children with autism spectrum disorder (ASD) during dental visits.
- Conditions
- Autism, Autism Disorders and Maternal Stress, Sensory Integration Disorder, Stress Biomarkers
- Trial name
- SMILED (NCT07887243)
- Testing
- Sensory-Adapted Dental Environment
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Jagiellonian University
Major Depressive Disorder, Sexual Behavior
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling
Large register based work has shown that starting on oral contraceptives (OCs) is associated with an increased risk of developing depressive episodes.
- Conditions
- Major Depressive Disorder, Sexual Behavior, Mood Disturbance, Mood Change
- Trial name
- NCT05212389
- Testing
- Femicept
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bulimia Nervosa
Step by Step Group Therapy for Bulimia Nervosa: Effectiveness and Mechanisms of Change.
This a pseudo-randomized clinical trial that examines if a specific group therapy for BN is effective in improving its symptomatology, and what variables mediate such improvements.
- Trial name
- SBSBN (NCT06063278)
- Testing
- l Group Therapy for BN.
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Behavior Problem
Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children
The goal of this clinical trial is to learn the effect of dexmedetomidine premedication in postoperative negative behavior changes in children compared to midazolam premedication.
- Trial name
- NCT06417125
- Testing
- Dexmedetomidine Hydrochloride, Midazolam, normal Saline
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Fujian Provincial Hospital
Status Epilepticus, Altered Level of Consciousness
eegCap Application in Paediatrics wiTh redUced GCS in REsus
Children frequently present with altered or reduced consciousness levels to emergency departments. By using EEG monitoring, subclinical seizure activity may be detected, leading to earlier pharmacological intervention and…
- Conditions
- Status Epilepticus, Altered Level of Consciousness, Non-epileptic Seizures, Epilepsy
- Trial name
- CAPTURE (NCT05259891)
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University College Cork
Adolescent Behavior, Substance Use
Young People's Health Assessment as Treatment and Health Guide
Background: Excessive alcohol and other substance use in adolescence is prevalent and has developmental consequences that extend into adulthood.
- Trial name
- YP-HEALTH (NCT03817255)
- Testing
- Substance use questionnaire, Physical activity
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Hot Flushes, Night Sweats
Progesterone for Perimenopausal Night Sweats
The purpose of this study is to test whether a oral micronized progesterone reduces the Vasomotor Symptom Score comprised of the number and severity of hot flushes and night sweats in perimenopausal women.
- Trial name
- NCT01464697
- Testing
- Oral micronized progesterone
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- University of British Columbia
Aphasia, Acquired
Conversation Group Treatment for Aphasia: Does it Work?
The proposed research will test the efficacy of group conversation treatment for people with aphasia and explore whether the effects of treatment differ as a result of the following factors: 1.
- Trial name
- NCT05113160
- Testing
- Conversation Treatment for Aphasia
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Boston University Charles River Campus
Autism
Sensory Adapted Dental Environment to Enhance Oral Care for Children With ASD
The goal of this project is to collect information that will support a later clinical trial on the effectiveness of a specially adapted dental environment for children who have difficulty tolerating oral care in the dental…
- Trial name
- SADE (NCT02077985)
- Testing
- Sensory Adapted Dental Environment
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Insomnia, Digestive Endoscopy
Changes in Ciprofol Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of ciprofol under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT06897007
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Major Depression
Motivational Interviews for Depression in Primary Care
The purpose of the study is to determine whether motivational interviewing with guideline-based medical management for depression will significantly improve time to depression recovery and increase the proportion of subjects in…
- Trial name
- NCT01114334
- Testing
- Guideline-Based Medical Management, Motivational Interviewing for Depression
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Denver Health and Hospital Authority
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