Clinical trials: Change; Mental
Depression, Anxiety
The Effect of Computerized Cognitive Training on Mood and Thinking Style Amongst Patients in Inpatient Settings
The purpose of this randomized controlled trial is to establish feasibility and provide initial estimates of efficacy of two computerized cognitive training procedures (a form of Positive Mental Imagery Training, PMIT, and a form…
- Conditions
- Depression, Anxiety, Anhedonia
- Trial name
- NCT02958228
- Testing
- Positive Mental Imagery Training (PMIT), Cognitive Control Training (CCT), Treatment as Usual
- Where
- 2 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Ruhr University of Bochum
Posttraumatic Stress Disorder (PTSD)
Estradiol-mediated Neural Plasticity as Potential Mediator of Neurofeedback Treatment Change for Traumatized Women
Post-traumatic stress disorder (PTSD) is a common debilitating disorder that affects many individuals exposed to aversive events. The severity of PTSD symptoms is positively correlated with amygdala activation.
- Trial name
- NCT03416764
- Testing
- EFP-NF training
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Severe Obesity, Psychological Distress
Trajectories of Resilience and Bariatric Surgery Outcomes
A high prevalence of psychological trauma on one hand and of psychiatric disorders, such as depression, anxiety, suicide attempts, addictions, and eating disorders on the other hand, has been reported in patients with severe…
- Conditions
- Severe Obesity, Psychological Distress, Bariatric Surgery Candidate
- Trial name
- ECLAIRCIE (NCT05341414)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Non-Suicidal Self-Injury, Emotional Dysregulation
Integrated Motivational Interviewing and Rational Emotive Behavior Therapy Intervention for Non-Suicidal Self-Injury Among Malaysian Primary School Students: A Feasibility Trial Protocol
This study aims to evaluate the feasibility and preliminary effects of the MIND-SET Intervention Module, an integrated Motivational Interviewing and Rational Emotive Behavior Therapy (MI-REBT) intervention, among Malaysian…
- Trial name
- MIND-SET (NCT07627061)
- Testing
- MIND-SET Intervention Module, PRISMA Mental Health Module
- Where
- Malaysia
- Volunteers
- 105 people
- Sponsor
- Universiti Utara Malaysia
Autism Spectrum Disorder
Effect of ESDM and PCIT-A in Autism Spectrum Disorder
Children with ASD often show disruptive behaviors. However, interventions that were specifically designed to improve these symptoms have not been sufficiently investigated, especially in children with level 1 to level 3 ASD.
- Trial name
- TAFF (NCT04722783)
- Testing
- Parent-Child-Interaction Therapy adapted for children with autism spectrum disorder (PCIT-A), Early Start Denver Model (ESDM) intervention, 1-hour ESDM
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Bruno Rhiner
Hypogonadism, Obesity
Testosterone, Metformin, or Both, for Hypogonadism in Obese Males
The purpose of this study is to examine the effects of metformin, testosterone, or both, in males with obesity-related hypogonadism.
- Trial name
- NCT02514629
- Testing
- Metformin, Testosterone Undecanoate, Metformin + Testosterone Undecanoate
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Ischemic Stroke, Cerebral Small Vessel Disease
Remote Preconditioning Over Time To Empower Cerebral Tissue
Previous studies in animals and humans has shown that brief periods of reduced blood flow to one organ or tissue in the body can help protect other tissues from subsequent injury caused by reduced blood flow such as a stroke.
- Conditions
- Ischemic Stroke, Cerebral Small Vessel Disease, Cognitive Decline
- Trial name
- REM-PROTECT (NCT02169739)
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, Los Angeles
Autism Spectrum Disorder
NarraTivAS - Narrative Family Therapy in Autism Spectrum
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction, along with restricted and repetitive patterns of behavior, interests, or activities.
- Trial name
- NarraTivAS (NCT07246395)
- Testing
- Narrative Family Therapy, Family Game Theory-based Intervention
- Where
- Portugal
- Volunteers
- 63 people
- Sponsor
- University of Coimbra
Health-related Quality of Life, Emotional Well-being
Enhancing Health-related Quality of Life, Emotional Well-being and Reducing Anxiety: Integrated Psychoeducational Nursing Interventions in Patients Undergoing Modified Electroconvulsive Therapy
Background: Electroconvulsive Therapy (ECT) remains a highly effective intervention for severe psychiatric disorders yet concerns about cognitive and emotional side effects persist.
- Conditions
- Health-related Quality of Life, Emotional Well-being, Modified Electroconvulsive Therapy
- Trial name
- NCT07579819
- Testing
- - After baseline measurement, the 120 patients were randomly divided into two equal groups: Study (Intervention) group (n = 60): received the multidisciplinary psychiatric nursing intervention session, No intervention (observational study)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shereen
Carer Stress Syndrome, Dementia
Effects of a Modified Mindfulness-based Cognitive Therapy for Family Caregivers of People With Dementia
Caring for people with dementia (PWD) poses many challenges which may cause high levels of caregiver stress. This study aims to investigate the effects of a modified Mindfulness-based Cognitive Therapy for stress reduction in the…
- Trial name
- NCT03354819
- Testing
- Modified MBCT, SIRE on dementia
- Where
- Hong Kong
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depressive Disorder, Anxiety Disorders
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
The Unified Protocol (UP) is an emotion-focused, cognitive-behavioural intervention that is developed to target core temperamental characteristics underlying anxiety and depressive disorders.
- Trial name
- NCT04091139
- Testing
- Unified protocol for adolescents (UP-A), Treatment as usual (TAU)
- Where
- Hong Kong
- Volunteers
- 27 people
- Sponsor
- Chinese University of Hong Kong
Borderline Personality Disorder
User Satisfaction Survey - Personality Disorder Service
Can we improve our community partners satisfaction with a change in how psychiatric consultations are delivered to their clients by our psychiatrist? This survey of users of the service will compare the level of satisfaction…
- Trial name
- NCT00202202
- Testing
- consultation format
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Queen's University
Neurodevelopmental Disorders, Congenital Heart Disease
Altered Cerebral Growth and Development in Infants With Congenital Heart Disease
Background: Congenital heart disease (CHD) is the most frequent inborn defect with an incidence of 1 in 100 newborns per year, i.e. 800 children born in Switzerland per year.
- Conditions
- Neurodevelopmental Disorders, Congenital Heart Disease, Brain Injuries, Fetal Growth Retardation
- Trial name
- NCT04233775
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Progesterone, Estrogens
Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
- Conditions
- Progesterone, Estrogens, Hearing, Psychoacoustics
- Trial name
- NCT00264407
- Testing
- Hormone Replacement Therapy - HRT
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Status Epilepticus, Seizure
EEG in In-hospital Patients With Seizure or Altered Mental State
In Kuopio University Department of Clinical Neurophysiology there have been designed a fast EEG electrode, that is suitable for acute emergency use.
- Conditions
- Status Epilepticus, Seizure, Altered Mental Status
- Trial name
- NCT02383745
- Testing
- Acute EEG with fast EEG electrode
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Tobacco Smoking, Alcohol-Related Disorders
Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease
Many Veterans who have chronic conditions like cardiovascular disease or diabetes smoke or drink too much alcohol, which can worsen the condition.
- Trial name
- MINDSET (NCT07039175)
- Testing
- MINDSET, Usual Care
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Chronic Tic Disorder
Modeling Tic Change During Behavior Therapy for Tics
Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems…
- Trial name
- NCT06270251
- Testing
- CBIT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Borderline Personality Disorder
Methylation Status of BDNF Gene After Dialectical Behavior Therapy in BPD
Borderline personality disorder (BPD) is a chronic and debilitating syndrome associated with considerable morbidity, mortality, and high rates of medical and psychiatric utilization services.
- Trial name
- NCT02134223
- Testing
- Dialectical behavior therapy, Treatment as Usual: any other drug or psychotherapy offered to participants, except DBT
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
HIV Infections
Phase IV, a Clinical Trial to Assess Safety and Convenience of the Change From DTG/3TC to BIC/FTC/TAF in People With HIV, Good Virological Control and Neuropsychiatric Vulnerabilities
In people infected with HIV, with suppressed HIV viral load and receiving treatment with DTG/3TC: The change to BIC/FTC/TAF will decrease the development of adverse events of neuropsychiatric etiology.
- Trial name
- MIND (NCT05549180)
- Where
- 14 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Fundacion SEIMC-GESIDA
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