Clinical trials: Change; Mental
Mood Disorder
Does Sleep Quality Change After Switch From Wellbutrin SR to Wellbutrin XL in Patients With Major Depressive Disorder?
Wellbutrin (bupropion) is an effective antidepressant (Thase, M 2005). It exists in instant release (IR), sustained release (SR) and extended release (XL) forms. The IR formulation was never approved for use in Canada.
- Trial name
- NCT00616915
- Testing
- Wellbutrin XL
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Dementia
Neuromodulation for Behavioral Changes in Neurological Disorders
The purpose of this study is to see if a focused ultrasound neuromodulation can be safely and effectively used to treat symptoms of emotional dysregulation such as agitation, irritability and anxiety
- Trial name
- NCT07718906
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- West Virginia University
Binge Drinking, Liver Injury
Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink
The goal of this double-blinded, randomized, crossover trial is to investigate the effects of NMN supplementation on liver function, liver fat content and lipid metabolism in healthy young subjects with acute binge drink.
- Conditions
- Binge Drinking, Liver Injury, Nutritional Supplementation, Hepatic Steatosis
- Trial name
- NMN-MeABD (NCT05882214)
- Testing
- β-nicotinamide Mononucleotide, Maltodextrin
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Sexual Abuse, Posttraumatic Stress Disorder
Efficacy of Cognitive Restructuring and Imagery Modification to Reduce the Feeling of Being Contaminated After Childhood Sexual Abuse
The purpose of this study is to determine whether a short term programme with internet research on the frequency of skin exchange and guided imagery modification is effective in the treatment of the feeling of being contaminated…
- Trial name
- NCT00976859
- Testing
- Imagery Modification, Waitlist control group
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Goethe University
Postnatal Depression
Behavioural Activation (BA) for Postnatal Depression in Blackpool
Is Behavioural Activation feasible, acceptable and potentially effective for mothers experiencing post natal depression in Blackpool? Phase 1: A series of single case studies which aim to examine and refine a) the appropriateness…
- Trial name
- BA (NCT04183582)
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- National Society for the Prevention of Cruelty to Children
Prodromal Alzheimer's Disease, Alzheimer Disease
COGNIFOOD-Changing the Carbohydrate/Fat-ratio to Prevent Cognitive Decline and Alzheimer Pathology: A Pilot Study
A 2-arm (sequence), 2-period, 2-treatments, single blinded (outcome assessor), randomized crossover-trial (12+12 weeks with immediate contrast) comparing a low-carbohydrate-high-fat diet (LCHF) with a high-carbohydrate-low-fat…
- Conditions
- Prodromal Alzheimer's Disease, Alzheimer Disease, Mild Cognitive Impairment, Neurocognitive Disorders
- Trial name
- NCT06105320
- Testing
- LCHF, HCLF
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Sleep Disorder (Disorder)
Evaluation of Changes in Sleep Efficiency Among PIC DU MIDI Staff Between Nights Spent at Home and Nights Spent in the Workplace Under High Altitude Conditions
Sleep organization and cardiorespiratory parameters are disrupted in extreme conditions such as high altitude. The pathophysiology of medical problems related to acute high-altitude exposure is partially understood, but sleep…
- Trial name
- ALTISOM (NCT07423988)
- Testing
- Sleep recording
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Stress, Mindfulness
Enhanced Stress Resilience Training for Residents
Burnout and overwhelming stress are growing issues in medicine and are associated with mental illness, performance deficits and diminished patient care.
- Conditions
- Stress, Mindfulness, Cognitive Change
- Trial name
- ESRT-R (NCT03518359)
- Testing
- Enhanced Stress Resilience Training (ESRT), Active Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety Disorders and Symptoms, Depression
Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes
The proposed project aims to test the efficacy and neural correlates of a behavioral treatment program comprised of positive activity interventions in a sample of individuals seeking treatment for anxiety or depression.
- Trial name
- NCT02330627
- Testing
- Positive Valence System Treatment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of California, San Diego
Cancer Survivors
Comparing Multicomponent and Aerobic Training: Impact on Fitness, Psychological and Quality of Life Parameters in Cancer Survivors Patients
The goal of this clinical trial is to evaluate if a multicomponent training program (MCT), including aerobic and resistance exercises, or an aerobic training program (AT) can improve physiological, physical fitness, mental…
- Trial name
- NCT06853613
- Testing
- Multicomponent Training Protocol, Aerobic Training Protocol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bari Aldo Moro
Alcohol Drinking, Binge Drinking
Alerta Alcohol. Web-based Computer-tailored Intervention for Binge-drinking Prevention in Spanish Adolescents
This study consists in the the design, implementation, and evaluation of the first web-based computer tailored intervention program aimed at the prevention of binge drinking in Spanish adolescents (Alerta Alcohol).
- Conditions
- Alcohol Drinking, Binge Drinking, Adolescent Behavior
- Trial name
- NCT03288896
- Testing
- Alerta Alcohol
- Where
- Spain
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- University of Seville
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
PTSD
Immunological Changes Through Narrative Treatment of Post-Traumatic Stress Disorder (PTSD) in Torture Victims
Posttraumatic stress disorder (PTSD) is associated with poor health, high health care utilization, and an increased risk for a variety of somatic, inflammatory and autoimmune diseases.
- Trial name
- NCT01206790
- Testing
- NET
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- University of Konstanz
Generalized Anxiety Disorder, Separation Anxiety Disorder
Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children
The objective of this project is to test the combination of active or placebo Attentional Bias Modification Treatment (ABMT) to either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for…
- Conditions
- Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Anxiety Disorder
- Trial name
- NCT01687764
- Testing
- Attentional Bias Modification Treatment (ABMT) - Active, Cognitive Behavioral Group Therapy, Psychoeducational Control Intervention
- Where
- 4 sites in United States, Australia and 2 more
- Volunteers
- 90 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depressive Disorder, Low Mood
Positive Feedback vs. No-Feedback Games for Behavioral Change
We aim to investigate here whether we can develop a reinforcement learning game which provides game-based feedback to encourage positive actions (behaviors) both inside and outside of the game.
- Trial name
- NCT06025838
- Testing
- positive feedback
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Bard College
Anorexia Nervosa
Look at Food and Lose Your Fear - Evaluation of a Computerized Attention Training (CAT) for Anorexia Nervosa Patients
The purpose of this study is to test the therapeutic effects of a computerized attention training for patients with Anorexia Nervosa (AN).
- Trial name
- CAT (NCT02484599)
- Testing
- Computerized attention training (CAT)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Cognitive Decline, Cognitive Change
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia.
- Conditions
- Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium
- Trial name
- NCT03839784
- Testing
- Neurocognition Interventions
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Nicotine Dependence
EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd < 5) using an 18-month longitudinal design and to relate these predictors of progression to the…
- Trial name
- NCT02129387
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Carbondale
Schizophrenia, Metabolic Syndrome
CHANGE -it is About Life
Schizophrenia is a life shortening disease, not only because of suicide but also because of increased mortality from natural causes.
- Trial name
- NCT01585493
- Testing
- Treatment as usual, Care coordinator, CHANGE
- Where
- Denmark
- Volunteers
- 428 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
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