Clinical trials: Change; Retina
Electronic Cigarette Use, Retina; Change
Nicotine Influence on the Retina Following the Use of Electronic Cigarette
The marketing of electronic cigarettes (e-cigarettes) in 2003 was initially intended to present a healthier alternative to smokers.
- Trial name
- NCT05801419
- Testing
- RETI-port/scan 21, Zilia Ocular, OCT-A
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Christian Casanova
Macular Degeneration
Drusen Morphology Changes in Nonexudative Age-related Degeneration After Oral Antioxidants Supplementation
Purpose: To determine drusen morphology (volume and area) changes in nonexudative age-related macular degeneration (AMD) after one year of oral supplementation with AREDS-like formulation.
- Trial name
- NCT02264938
- Testing
- Antioxidant
- Volunteers
- 35 people
- Sponsor
- Germans Trias i Pujol Hospital
High Myopia, Pregnancy Related
Physiologic Ocular Changes During Pregnancy in Women With High Myopia.
The prevalence of myopia is seemingly increasing, and it is one of the major causes of blindness. High myopia is defined as a refractive error with spherical equivalent exceeding -6 diopters and/or the axial length longer than…
- Trial name
- NCT04773574
- Testing
- Corneal topography, Optical coherence tomography (OCT) and Optical coherence tomography angiography (OCTA)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Vitiligo, Chorioretinopathy
Ocular Changes in Vitiligo Patients on Therapy
Vitiligo patients on systemic and local therapy may have some ocular adverse effects associated with the disease and its therapy.
- Conditions
- Vitiligo, Chorioretinopathy, Chorioretinitis
- Trial name
- NCT05335746
- Testing
- Optical coherence tomography angiography (OCT-A)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Retinal Ischemia, Diabetes Complications
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Conditions
- Retinal Ischemia, Diabetes Complications, Ischemia, Diabetes Mellitus, Type 1
- Trial name
- NCT03906383
- Testing
- Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Covid19
OCTA Study: Retinal Vascular Changes in Patients With SARS-CoV-2 Infection
This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that have been affected by COVID-19.
- Trial name
- NCT04601012
- Testing
- Optical coherence tomography angiography
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Change; Retina
Optical Coherence Tomography (OCT) in Elderly Patients After Elective Orthopaedic Surgery
After obtaining informed consent each patient underwent OCT examination, usually one day before elective orthopaedic surgery (knee replacement). The OCT examination was repeated after the surgery.
- Trial name
- NCT04311801
- Testing
- Optical Coherence Tomography
- Volunteers
- 30 people
- Sponsor
- Masaryk Hospital Usti nad Labem
Eye Diseases, Hereditary
Fundus Changes in the Microphthalmy Eyes
The goal is to describe the fundamental aspects of fundoscopic eye in patients with microphthalmia
- Trial name
- NCT00811512
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital de Olhos Sadalla Amin Ghanem
Retinitis Pigmentosa
A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa
This is a Phase 3 study to Assess the Efficacy, Safety and Tolerability of OCU400 in patients with retinitis pigmentosa (RP) associated with RHO mutations and patients with any other RP associated mutation with a clinical…
- Trial name
- liMeliGhT (NCT06388200)
- Testing
- Sub-Retinal Administration of OCU400-301
- Where
- 17 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- Ocugen
Diabetic Macular Edema
Changes to the Retina Following Anti-VEGF Treatments for Diabetic Macular Edema
anti-VEGF therapy is an established method to control leakage and abnormal growth of retinal blood vessels. Questions on the long-term effect on the retina, intraocular pressure and on the overall retinal perfusion from these…
- Trial name
- NCT02979665
- Testing
- Ranibizumab Ophthalmic
- Volunteers
- 51 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Retinal Vascular, Retinal Disease
Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus
This study is directed to evaluate the role of Optical Coherence Tomography Angiography (OCT-A) in the evaluation of the perifoveal vascular network in type 1 diabetic patients, and to investigate the relationship between…
- Conditions
- Retinal Vascular, Retinal Disease, Retinal Ischemia, Retinal Ischaemia Due to Type 1 Diabetes Mellitus
- Trial name
- NCT03422965
- Testing
- Optical Coherence Tomography Angiography, Blood test, Urine test
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Diabetic Retinopathy
Long-term Retinal Changes After Topical Citicoline Administration in Patients With Mild Signs of Diabetic Retinopathy in Type 1 Diabetes Mellitus.
Citicoline (cytidine-5'-diphosphocholine) is an essential precursor in the synthesis of phosphatidylcholine, a component of cell membranes.
- Trial name
- NCT04009980
- Testing
- OMK2 group
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Exudative Age-related Macular Degeneration
Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab
Exudative age-related macular degeneration (ARMD) is complicated by choroidal neovascularization (CNV). Although anti-vascular endothelial growth factor treatment is the gold standard treatment, recurrence is the main limitation…
- Trial name
- NCT01810042
- Testing
- ranibizumab
- Where
- 2 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Pusan National University Hospital
Thyroid Associated Orbitopathy
Changes in Orbital Macrovascular and Intraocular Microvascular Blood Flow After Orbital Decompression Surgery in Patients With Thyroid Eye Disease
This study aims to evaluate the effects of balanced orbital decompression surgery in patients with inactive thyroid-associated orbitopathy.
- Trial name
- BOD-VASC (NCT07393230)
- Testing
- Balanced Orbital Decompression Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Epiretinal Membrane
Effect of Air-tamponade on Intraretinal Cystoid Changes After Membrane Peeling
Patients with intraretinal cystoid changes before scheduled membrane peeling for epiretinal membranes are included. Patients are randomized for balanced salt solution (BSS) or air-tamponade.
- Trial name
- NCT03457584
- Testing
- air arm, BSS arm
- Where
- Austria
- Volunteers
- 96 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Age Related Macular Degeneration
Triple Therapy - PDT Plus IVD and Intravitreal Ranibizumab Versus Lucentis Monotherapy to Treat Age-Related Macular Degeneration
The purpose of this study is to compare triple therapy using Photodynamic therapy, intravitreal Dexamethasone and intravitreal Ranibizumab injections versus monotherapy with intravitreal Ranibizumab alone for the treatment of…
- Trial name
- PDEX (NCT00390208)
- Testing
- ranibizumab, dexamethasone and verteporfin, Ranibizumab
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bay Area Retina Associates
Diabetic Retinopathy, Neurodegeneration
Retinal Neurodegenerative and Vascular Changes in Diabetic Patients
Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with…
- Trial name
- NCT04637217
- Testing
- Optical Coherence Tomography
- Where
- Romania
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Arterial Hypertension, Blood Pressure, High
Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension
To evaluate whether in patients with initially poorly-controlled arterial hypertension, structural and functional differences in the retina and choroid remain after achieving a well-controlled blood pressure.
- Trial name
- NCT06098300
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy (DR), Retinal Microvascular Changes
Relation Between Glycemic Control and Retinal Microvascular Changes in Diabetic Patients Using OCTA
An observational cross-sectional comparative study which will be conducted in the Department of Ophthalmology, Sohag University Hospital, Egypt to detect the relation between glycemic control and retinal microvascular changes in…
- Trial name
- Retinopathy (NCT07726381)
- Volunteers
- 50 people
- Sponsor
- Sohag University