Clinical trials: Change; Retina
Diabetic Retinopathy, Type 1 Diabetes
Effect of Omega-3 Fatty Acids on Eye Blood Vessels in Type 1 Diabetes
This double-blind, placebo-controlled randomized clinical trial evaluates the effects of omega-3 fatty acid supplementation on retinal vascular structure and function in children and adolescents with type 1 diabetes.
- Conditions
- Diabetic Retinopathy, Type 1 Diabetes, Omega 3 Fatty Acids
- Trial name
- O3RETINA (NCT07255326)
- Testing
- Omega 3 Fish Oil supplements
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- University of Faisalabad
Diabetic Retinopathy (DR), Cardiopulmonary Bypass
Choroidal Changes During Cardiopulmonary Bypass
This prospective observational study investigates the impact of pulsatile versus non-pulsatile cardiopulmonary bypass (CPB) flow on choroidal circulation in diabetic and non-diabetic patients undergoing elective coronary artery…
- Conditions
- Diabetic Retinopathy (DR), Cardiopulmonary Bypass, Retinal Vascular Diseases
- Trial name
- NCT07034612
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Samsun University
Maculopathy
Assessment Of Diabetic Maculopathy Changes After Phacoemulsification by Using Optical Coherence Tomography
Investigators aimed to assess the macular changes with OCT after uncomplicated phacoemulsification surgery in diabetic patients with non proliferative diabetic retinopathy (NPDR) at the time of surgery and the effect of…
- Trial name
- Maculopathy (NCT05547789)
- Testing
- non steroidal anti inflammatory drugs
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Diabetic Retinopathy
Assessment of Retinal Microvascular Changes by OCT Angiography in Diabetic Retinopathy
This observational cross-sectional study aims to assess retinal microvascular changes using optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy.
- Trial name
- NCT07747428
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Alzheimer Disease, Mild Cognitive Impairment
Atlas of Retinal Imaging in Alzheimer's Study
The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia, Aging
- Trial name
- ARIAS (NCT03862222)
- Testing
- Retinal Imaging, Pupillometry, Contrast Sensitivity
- Where
- 4 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Diabetic Vitreous Hemorrhage, Tractional Retinal Detachment
Assessment of Retinal Vascular Changes With and Without ILM Peeling in Diabetic Vitrectomy Using OCT-A.
Tractional retinal detachment (TRD) that involves the macula and non-clearing vitreous hemorrhage are the main causes of permanent vision loss in patients with diabetic retinopathy and requires prompt surgical intervention.
- Trial name
- NCT05739539
- Testing
- optical coherence tomography angiography, spectral domain optical coherence tomography
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Kasr El Aini Hospital
Diabetic Retinopathy
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
An online survey (n=1,500) and 4 focus groups will be conducted with Latinx patients with diabetes (n=20) to obtain preliminary data regarding whether and how patient and clinician video testimonial interventions (n=6) increase…
- Trial name
- NCT06257082
- Testing
- Online Survey
- Where
- United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus Type 1, Diabetic Maculopathy
Diameter Changes of Retinal Vessels During Hypoxia
The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
- Trial name
- NCT01689090
- Testing
- COX inhibitor, L-NG-monomethyl arginine citrate, COX inhibitor + L-NG-monomethyl arginine citrate
- Where
- Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Age-Related Macular Degeneration
Visual Function Change in Wet Age-related Macular Degeneration Patients With Better Baseline Visual Acuity
Although the number of wet AMD patients with the better visual acuity is increasing, the visual improvement in patients with the better vision may not be so significant after anti-vascular endothelial growth factor (VEGF)…
- Trial name
- NCT06330220
- Testing
- Aflibercept Injection [Eylea]
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
Recently, intravitreal bevacizumab (Avastin) injection has gained popularity as a potential treatment of intraocular neovascularization (CNV) associated with age related macular degeneration and diabetic retinopathy.
- Trial name
- NCT00423059
- Testing
- bevacizumab
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Uveitis, Macular Edema
Effects of Conbercept in Refractory Uveitic Macular Edema and VEGF
As a primary exploratory study, this study aims to evaluate the short-term effectiveness of intravitreal Conbercept injection in UME, and to explore the correlation between inflammatory factors like VEGF and the responsiveness to…
- Conditions
- Uveitis, Macular Edema, Vascular Endothelial Growth Factor, Effect of Drugs
- Trial name
- NCT04296838
- Testing
- intravitreal injection of Conbercept
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Peking Union Medical College Hospital
Age-related Macular Degeneration
Global Atrophie Biomarker Evaluation Study (GABiE)
To investigate the use of microperimetry and SS-OCT in assessing the natural changes of retinal sensitivity and anatomy in the perilesional zone of geographic atrophy areas in patients with dry age-related macular degeneration.
- Trial name
- GABiE (NCT03935126)
- Testing
- Diagnostics
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 3 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease
Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT01928212
- Testing
- Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Intermediate AMD
A Clinical Trial Evaluating the Safety and Efficacy of a New Light Combination Therapy Addressing Intermediate AMD
The proposed clinical investigation wants primary to validate the safety of the innovative light therapy approach and in second priority provide insight and confirmations on therapeutic effect.
- Trial name
- retinaSEES-PoC (NCT06557369)
- Testing
- reSEES
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Oculox Technologies SA
Central Serous Chorioretinopathy
The Changes of Retinal Capillaries After Half-dose PDT Measured by OCTA in Eyes With CSC
To determine changes in retinal and choroidal capillaries with optical coherence tomographic angiography (OCTA) after half-dose photodynamic therapy (hd-PDT) in eyes with central serous chorioretinopathy (CSC).
- Trial name
- NCT03692169
- Testing
- Half-dose photodynamic therapy
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Jin Chen-jin
Diabetic Retinopathy
Evaluation of Retinal Changes in Systemic Darbepoetin Alpha Treatment in Patients With Diabetes Mellitus
The purpose of this study is to determine whether systemic administration of darbepoetin alpha results in the progression or regression of diabetic macular edema.
- Trial name
- EPOinDR (NCT00704652)
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy
Investigating the Structural and Functional Changes to the Retina Following PRP in Diabetic Retinopathy Patients
Laser therapy is an established method to stabilize and control proliferative diabetic eye disease. Questions on the long-term effect on the retina from these treatments remain to be answered.
- Trial name
- NCT02621580
- Testing
- Pan-Retinal Photocoagulation
- Volunteers
- 24 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Epiretinal Membrane, Macular Oedema
Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After Vitrectomy
The goal of this interventional study is to assess the dynamics of structural and functional retinal changes in eyes with epiretinal membrane (ERM) after pars plana vitrectomy (PPV).
- Conditions
- Epiretinal Membrane, Macular Oedema, Macular Diseases, Retinal Diseases
- Trial name
- NCT07165626
- Testing
- Subtreshold micropulse laser therapy, Pars plana vitrectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
A History of Radiation Therapy for a Tumor in the Vicinity of the Retina(s)
Retinal Oxygen Function After Radiation Therapy
The investigators propose using retinal oximetry to assess for abnormalities in regional retinal oxygen consumption in previously- irradiated patients, and relate these abnormalities to changes in regional retinal function (i.e.
- Trial name
- NCT02043470
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Glaucoma, Macular Pucker
Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study
Since the introduction of vitrectomy in 1971, this procedure has become the third most frequently performed ophthalmic surgery. Approximately 225,000 vitrectomies are performed annually in the United States and indications…
- Conditions
- Glaucoma, Macular Pucker, Macula Hole, Vitreomacular Traction
- Trial name
- PROVE (NCT01162356)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University